| Project/Area Number |
04454291
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
TADA Masao Tohoku Univ.Inst.of Development, Aging and Cancer, Assoc.Prof., 加齢医学研究所, 助教授 (10006083)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Takehiko Tohoku Univ., Cyclotron and Rl Center, Instr., サイクロトロンRIセンター, 助手 (70238632)
IWATA Ren Tohoku Univ., Cyclotron and RI Center, Assoc.Prof., サイクロトロンRIセンター, 助教授 (60143038)
KUBOTA Kazuo Tohoku Univ., Inst.of Development, Aging and Cancer, Assoc.Prof., 加齢医学研究所, 助教授 (40161674)
SUGIYAMA Hiroshi Tohoku Univ., Inst.for Chem.Res.Sci., Assoc.Prof., 反応化学研究所, 助教授 (90006304)
FUKUDA Hiroshi Tohoku Univ., Inst.of Development, Aging and Cancer, Prof., 加齢医学研究所, 教授 (30125645)
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| Project Period (FY) |
1992 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1994: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1993: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1992: ¥4,000,000 (Direct Cost: ¥4,000,000)
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| Keywords | Synthesis / [fluoroacetyl-^<18>F] Fluoromelatonin / [^<18>F] Fluoride / Cyclotron / Radioactive isotope / N^<omega>- [^<18>F] Fluoroacetylserotonin / N^ω-^<18>F]フルオロアセチルセロトニン / [fluoroacetyl-^<18>F]フルオロメラトニン / 診断 / 2-デオキシ-2-[^<18>F]フルオロ-D-ガラクトース / 陽電子放出核種 / N^ω-[^<18>F]フルオロアセチルセロトニン / 化学合成 / [fluroacetyl-^<18>F]フルオロメラトニン / N^ω-[^<18>F]フルオロアセチルメラトニン / 標識ホルモン |
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| Research Abstract |
An efficient synthesis of [fluoroacetyl-^<18>F] fluoromelatonin (N^<omega>- [^<18>F] Fluoroacety1-5-methoxytryptamine) starting from [^<18>F]fluoride has been established. [^<18>F] Fluoride was produced by the ^<18>O (p, n)^<18>F nuclear reaction from a circulating 20%-enriched [^<18>O] water target using the Tohoku University Cyclotron. The ^<18>F nuclide thereby formed was converted to potassium [^<18>F] fluoride. The reaction of[^<18>F]fluoride with ethyl p-toluenesulfonyloxyacetate derived from ethyl bromoacetate with silver p-toluenesulfonate afforded ethyl [^<18>F] fluoroacetate, which was then hydrolyzed with alkali and condensed with 5-methoxytryptamine in the presence of dicyclohexylcarbodiimide to give the desired radioactive isotope in a 26.7% radiochemical yield. The purity, specific activity and the total time required for its synthesis are>98%, 540 mCi/mumol and ca.90 min, respectively.
N^<omega>- [^<18>F] Fluoroacetylserotonin was synthesized under similar conditions in 22.6% radiochemical yield. The purity and specific activity of the hormone are>98% and 600 mCi/mumol, respectively.
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