| Project/Area Number |
04454295
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
HIRAOKA Masahiro Kyoto Univ.Dept.of Radiology Associate Prof., 医学部, 助教授 (70173218)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Kouichi Chiba Univ.Fac.of Engineering Associate Prof., 工学部, 助教授 (90108225)
ABE Mitsuyuki Kyoto Univ.Fac.of Medicine Prof/., 医学部, 教授 (00025587)
NAGATA Yasushi Kyoto Univ.Fac.of Medicine assist.Prof., 医学部, 助手 (10228033)
NISHIMURA Yasumasa Kyoto Univ.Fac.of Medicine Lecturer, 医学部, 講師 (00218207)
増永 慎一郎 京都大学, 原子炉実験所, 助手 (80238914)
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| Project Period (FY) |
1992 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1994: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1993: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1992: ¥3,300,000 (Direct Cost: ¥3,300,000)
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| Keywords | cancer treatment / hyperthermia / microwave / interstitial hyperthermia / anntena / electromagnetic wave / phantom / 温熱療法 / マイクロ波アンテナ |
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| Research Abstract |
We have developed a microwave coaxial ring-slot applicator for interstitial hyperthermia in cancer therapy. The applicator is co-axial slots antennas made of a 0.86 mm outer diameter coaxial cable, and is used at a frequency of 400-430 MHz microwave. Several ring slots, which radiate microwave power into the surrounding tissue, are placed at equidistant intervals along this cable on the outer conductors, and the tip of the coaxial cable is short-circuited to expand the heating area around the tip of the applicator. The antennas can be inserted into a 21 G plastic catheter and the SAR distribution along them can be changed by ajusting the parameters of the slots. Multiple coaxial slots are arranged at short intervals on the outer conductor of the cable. Each antenna is loaded into a thin plastic catheter and an array of the antennas is then inserted into a tumor.
The heating distributions characteristics of this applicator were investigated in the muscle-equivalent agar phantoms. The advantages of this applicator demonstrated were the relatively large haeting area and the relatively uniform heating area along the axis of the applicator. These advantages have been shown in animal experiments using the muscle and the implanted tumor. Histopathological examinations revealed massive coagulation necrosis of the tumors which were effectively heated with this applicater.
The applicator was designed to be used with a 430 MHz microwave hyperthermia system, so that the temperature measurement and temperature control system equipped with the system are also availabel for the interstitial hyperthermia.
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