| Project/Area Number |
04454306
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Yokohama City University |
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Principal Investigator |
KOSAKA Kenji Yokohama City Univercity Depertment of Psychiatry, Professor, 医学部, 教授 (60023800)
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| Co-Investigator(Kenkyū-buntansha) |
ODAWARA Toshinari Yokohama City Univercity Depertment of Psychiatry, Assistant, 医学部, 助手 (00244426)
ISEKI Eizo Yokohama City Univercity Depertment of Psychiatry, Lecturer, 医学部, 講師 (30203061)
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| Project Period (FY) |
1992 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥5,800,000 (Direct Cost: ¥5,800,000)
Fiscal Year 1994: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1992: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Diffuse Lewy body disease / Alzheimer-type dementia / Senile plaque / Neurofibrillary tangle / Ubiquitin-positive thread-like structure / Intraglial tau2-positive structure / Biochemical findings / 扁桃核 / ユビキチン免疫染色 / tau-2免疫染色 |
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| Research Abstract |
The differences of diffuse Lewy body disease (DLBD) with Alzheimer-type dementia (ATD) were examined from clinical, pathological, immuno-histochemical and biochemical view-points.
1) Most of Japanese elderly DLBD patients had the common form, and most of cases with the pure from suffered from DLBD at the younger age than 40 years. On the other hand, most Euro-American DLBD cases were the elderly.
2) DLBD can be clinically as well as pathologically differentiated from ATD.Therefore, we can not agree with the opinoin of Hansen et al that DLBD is a subtype of ATD.
3) Ubiquitin-positive thread-like structures (UPT) and intraglial tau2-positive structures (ITS) are specific to DLBD.
4) UPT are differentiated from neuropil threads in that they are tau-, NFT-, and beta protein-immunonegative. They are found not only in the CA2-3 of the hippocampus, but also in the amygdala, parahippocampal cortex, nucleus basalis of Meynert and hypothalamus. There are two kinds of UPT : (1) fibrillar or fusiform, and (2) lod-like ones. The former are associated with distal axons, and the latter with proxismal axons.
5) It was suggested that ITS-containing cells are microglia.
6) Our biochemical study revealed that 5-HT and noradrenaline activities in the cerebral cortex were much lower in DLBD than in ATD.
7) In the amygdala, which is one of the preferential sites of Lewy bodies, they were more frequently found in the medical parts of the accessory basal and basal nuclei.
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