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A comparative study of diffuse Lewy body disease and Alzheimer type dementia

Research Project

Project/Area Number 04454306
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionYokohama City University

Principal Investigator

KOSAKA Kenji  Yokohama City Univercity Depertment of Psychiatry, Professor, 医学部, 教授 (60023800)

Co-Investigator(Kenkyū-buntansha) ODAWARA Toshinari  Yokohama City Univercity Depertment of Psychiatry, Assistant, 医学部, 助手 (00244426)
ISEKI Eizo  Yokohama City Univercity Depertment of Psychiatry, Lecturer, 医学部, 講師 (30203061)
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥5,800,000 (Direct Cost: ¥5,800,000)
Fiscal Year 1994: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1992: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsDiffuse Lewy body disease / Alzheimer-type dementia / Senile plaque / Neurofibrillary tangle / Ubiquitin-positive thread-like structure / Intraglial tau2-positive structure / Biochemical findings / 扁桃核 / ユビキチン免疫染色 / tau-2免疫染色
Research Abstract

The differences of diffuse Lewy body disease (DLBD) with Alzheimer-type dementia (ATD) were examined from clinical, pathological, immuno-histochemical and biochemical view-points.
1) Most of Japanese elderly DLBD patients had the common form, and most of cases with the pure from suffered from DLBD at the younger age than 40 years. On the other hand, most Euro-American DLBD cases were the elderly.
2) DLBD can be clinically as well as pathologically differentiated from ATD.Therefore, we can not agree with the opinoin of Hansen et al that DLBD is a subtype of ATD.
3) Ubiquitin-positive thread-like structures (UPT) and intraglial tau2-positive structures (ITS) are specific to DLBD.
4) UPT are differentiated from neuropil threads in that they are tau-, NFT-, and beta protein-immunonegative. They are found not only in the CA2-3 of the hippocampus, but also in the amygdala, parahippocampal cortex, nucleus basalis of Meynert and hypothalamus. There are two kinds of UPT : (1) fibrillar or fusiform, and (2) lod-like ones. The former are associated with distal axons, and the latter with proxismal axons.
5) It was suggested that ITS-containing cells are microglia.
6) Our biochemical study revealed that 5-HT and noradrenaline activities in the cerebral cortex were much lower in DLBD than in ATD.
7) In the amygdala, which is one of the preferential sites of Lewy bodies, they were more frequently found in the medical parts of the accessory basal and basal nuclei.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] 小田原俊成,井関栄三,小阪憲司: "アルツハイマー型痴呆とdiffuse Lewy body disease" Dementia. 7. 75-83 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kosaka K.: "Dementia and neuropathology in Lewy body disease" Advances in Neurology. 60. 456-463 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Iseki E,Odawara T,Kosaka K,et al: "Evaluation of neuropatholgical stages based in quantitication of senile changes in non-demented elderly individuals and Alzheimer-type dementia" Neuropathology. 13. 147-152 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 小田原俊成,井関栄三,小阪憲司: "びらん性Lewy小体病とAlzheimer型痴呆の比較研究" 病態生理. 13. 67-69 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 小阪憲司: "レビ-小体と痴呆" Dementia. 8. 6-12 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 小阪憲司: "Alzheimer型痴呆およびびまん性Lewy小体病に伴うパーキンソニズム" 内科. 73. 835-838 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 小阪憲司: "Diffuse Lewy body disease(DLBD)" Modern Physician. 14. 767-769 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 井関栄三,小阪憲司: "びまん性レビ-小体病" Geriatric Medicine. 32. 1437-1442 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Odawara T,Iseki E,Kosaka K,et al: "Incidevce and distribution of senile plaques and neurofibrillary tangles in late-onset diffuse Lewy body disease" Neuropathology. 14. 7-11 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 小田原俊成: "びまん性レビ-小体病の臨床病理学的研究" 横浜医学. 44. 599-607 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 近藤直樹,小阪憲司 ほか: "びまん性レビ-小体病の臨床病理学的検討-純粋型1症例を含む自験4別検例を中心として" 臨床精神医学. 24. 43-50 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Odawara T,et al: "Alzheimer-type dementia and diffuse Lewy body disease" Dementia. 7. 75-83 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kosaka K: "Dementia and neuropathology in Lewy body disease" Adv Neurol. 60. 456-463 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Iseki E,et al: "Evaluation of neuropathological stages based in quantification of senile changes in non-demented elderly individuals and Alzheimertype dementia" Neuropathol. 13. 147-152 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Odawara T,et al: "A comparative study of diffuse Lewy body disease and Alzheimer-type dementia" Byoutai Seiri. 13. 67-69 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kosaka K: "Lewy bodies and dementia" Dementia. 8. 6-12 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kosaka K: "Parkinsonism in Alzheimer-type dementia and diffuse Lewy body disease" Intern Med. 73. 835-838 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kosaka K: "Diffuse Lewy body disease (DLBD)" Mod Physic. 14. 767-769 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Iseki E,et al: "Diffuse Lewy body disease" Geriat Med. 32. 1437-1442 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Odawara T,et al: "Incidence and distribution of senile plaques and neurofibrillary tangles in late-onset diffuse Lewy body disease" Neuropathology. 14. 7-17 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Odawara T,et al: "A clinicopathological study of diffuse Lewy body disease" Yokoha Med. 44. 599-607 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kondo N,et al: "A clinicopathological study of diffuse Lewy body disease -- Our four autopsied cases" Clin Psychiat. 24. 43-50 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kosaka K,: "Dementia and Neuropathology in Lewy Body Disease" Advances in Neurology. 60. 456-463 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 近藤直樹、ほか: "びまん性レビー小体病の2剖検例-臨床症状およびMRI所見の検討21GC02:精神医学" 35. 999-1002 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kosaka K,: "Dementia and Neuropathology in Lewy body disease" Parkinson/Alzheimer Digest. 6. 5-6 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 小田原俊成、ほか: "びまん性Lewy小体病とAlzheimer型痴呆症の比較研究" 病態生理. 13. 67-69 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 小阪憲司: "レビー小体と痴呆" Dementia. 8. 6-12 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Odawara T,et al: "An autopsied case of juvenile parkinsonism and dementia,with a widespread occurrence of Lewy bodies and spheroids" Clinical Neuropathology. 11. 131-134 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 小阪 憲司: "びまん性レビー小体病の臨床と病理" 北陸神経精神医学雑誌. 6. 1-5 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 小田原 俊成 ほか: "アルツハイマー型痴呆とdiffuse Lewy body disease" Dementia. 7. 75-83 (1993)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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