Effect of Continuous Intraarterial Infusion of Vasodilator and Anticoagulant to Extend the Survial of a Pedicled Flap Through Unusual Routes in Rabbit

• Project/Area Number: 04454314
• Research Category: Grant-in-Aid for General Scientific Research (B)
• Allocation Type: Single-year Grants
• Research Field: General surgery
• Research Institution: SHINSHU UNIVERSITY
• Principal Investigator: MATSUO Kiyoshi Shinshu University School of Medicine, Professor, 医学部, 教授 (20135156)
• Project Period (FY): 1992 – 1994
• Project Status: Completed (Fiscal Year 1994)
• Budget Amount: ¥6,700,000 (Direct Cost: ¥6,700,000); Fiscal Year 1994: ¥1,100,000 (Direct Cost: ¥1,100,000); Fiscal Year 1993: ¥1,100,000 (Direct Cost: ¥1,100,000); Fiscal Year 1992: ¥4,500,000 (Direct Cost: ¥4,500,000)
• Keywords: FLAP / SURVIVAL LENGTH / CONTINUOS INTRAARTERIAL INFUSION / VASODILATOR / ANTICOAGULANT

Research Abstract

When a pedicled flap is extended over the safety length, the distal portion of the flap may necrose. To safely extend the survival length of the flap, surgical delay, intravenous and intraarterial administration of vasodilators and anticoagulants have been performed. As the intraarterial administration in flap surgery has a risk of thromboembolism, it has been rarely reported. In our experimental rabbit model, to preserve the main arterial inflow to the flap and to reduce the risk of thromboembolism, the infusion of PGE_1 was administered via a upstream branch of the nutrient artery in retrograde fashion, or via a nutrient artery of next neighbor vascular territory in the extended portion of the flap in advance fashion. Results showed that both the former and the latter route increases the vascularity and the survial length of the flap. In conclusion, it is important keeping anticoagulant condition in the flap until the revascularization between the flap and recipient site occurs as well as increasing vascularity, to extend the survival length of the flap.

Research Products

• [Publications] Kiyoshi Matsuo et al.: "Continuous Iutraarterial Iufusioncf Plostaglandin E_1 and Heparin to Extend and Implove the Survival of Dedided Musdulocutanecus Flaps Through Unusual Routes:A Clinnal Prelivninary Report" Aun Plast Surg. 29. 314-320 (1992)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] 松尾清-波利井清紀・鳥居修平編著-: "皮弁移植法-最近の進歩-持続動注による皮弁拡大と安全性向上の試み" 克誠堂出版株式会社, 6-224 (1993)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Kiyoshi Matsuo et al.: "Continuous Intraarteria Infusion of Prostaglandin E_1 and Heparin to Extend and Improve the Survival of Pedicled Musculocutanous Flaps Through Unusual Route : A Cinical Preliminary Report" Ann.Plast.Surg.19. 314-320 (1992)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Kiyoshi Matsuo (in Eds.K.Harii & S.Torii): A Trial to Extend and Ensure the Survival Length of Flap by Continuous Intraarterial Infusion. KOKUSEIDI RECENT ADVANCE IN FLAP SURGERY, (1993)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Kiyoshi Matsuo et all: "Continuors Intraarteriud Infusion of Phategland in Ei and Heparin to Ertend and Inprove the Surviucl of Pedicled Musudoatanocus Flaps Through Unusual Routes:A Climical Prelininauy Report" Ann Plasc Surg. 29. 314-920 (1992)
• [Publications] 松尾清-波利井清他.鳥居修平編著: "皮弁移植法-最近の進歩-持続動注による皮弁拡大と安全性向上の試み" 克誠堂出版株式会社, 6/224 (1993)
• [Publications] Kiyoshi Matsuo,et al: "Continuous Intraarterial Infusion of Prostaglandin E_1 and Heparin to Extend and Imprae the Survival of Pedicled Musalocutaneous Flaps through Unusual Routes:A Clinical Preliminary Report" Annals of Plastic Surgery. 29. 314-320 (1992)
• [Publications] 松尾清, (波利井清紀,鳥居修平編): "皮弁移植法:最近の進歩 持続動注による皮弁拡大と安全性向上の試み" 克誠堂出版 東京, 224 (17-22) (1993)
• [Publications] Kiyoshi Matsuo,etal.: "Contimous Intraarterial Iufusion of Prostaglandin E,and Heparim to Extend and Improve the Survival of Pedicled Musculocutaneous Flaps Through Virusual Routes :A Clinical Proliminary Report" Annals of Plastic Surgery. 29. 314-320 (1992)