| Project/Area Number |
04454326
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Gunma University |
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Principal Investigator |
NAGAMACHI Yukio Gunma University, School of Medicine Professor, 医学部, 教授 (30008289)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIZUME Tatsuo Gunma Univ.School of Medicine Lecturer, 医学部, 教務員 (50241899)
ASAO Takayuki Gunma Univ.School of Medicine Assistant, 医学部, 助手 (40212469)
TAKENOSHITA Sei-ichi Gunma Univ.School of Medicine Associate Professor, 医学部, 助教授 (10167489)
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1993: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1992: ¥4,200,000 (Direct Cost: ¥4,200,000)
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| Keywords | Stable Strontium(Sr) / multidisciplinary treatment / cytoprotection / Immunochemotherapy / ストロンチウム / 生体防御 |
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| Research Abstract |
The pupose of the present investigation is to elucidate the effect and cytoprotective mechanisms of Sr for biological response and to estabilish the clinical usefulness for the adjuvant cancer therapy. Administration of anti-cancer drugs or irradiation on non cancer-bearing rats increased serum ACTH, Cortisol and IAP levels. Such negative effects on the host's immunity were reduced by the combined administration of Sr with the anticancer drugs. Using the cancer-bearing rat models, Sr alone showed no effects on the tumor growth rate. However, combined adiministration of Sr, PSK and anti-cancer drugs significantly inhibited the tumor growth without reducing the host's immunity. The same results were obtained using the nude mouse models. Sr was indicated to act without affecting the T-cell function.
In conclusion, the effectiveness of Sr on multidisciplinary cancer treatment was suggested. Further study should be going on to identify the effector cells of Sr in the micromorphological and cytochemical aspects.
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