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Roles of liver and intestinal fatty acid binding protein gastrointestinal tract participating in fat absorption and colorectal cancer

Research Project

Project/Area Number 04454328
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionNiigata University

Principal Investigator

HATAKEYAMA Katsuyoshi  Niigata Univ.School of Medicine, Professor, 医学部, 教授 (90134923)

Co-Investigator(Kenkyū-buntansha) MURAKAMI Hiroshi  Niigata Univ.School of Medicine, Clinical fellow, 医学部・附属病院, 医員
SAKAI Yasuo  Niigata Univ.School of Medicine, Assistant instructor, 医学部・附属病院, 助手 (60251823)
瀧井 康公  新潟大学, 医学部附属病院, 医員
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥5,100,000 (Direct Cost: ¥5,100,000)
Fiscal Year 1993: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1992: ¥3,900,000 (Direct Cost: ¥3,900,000)
Keywordsfatty acid binding protein / FABP / Liver and Intestinal FABP / Immunostaining / Induction by high fat diet / FABP in colorectal cancer / 脂肪吸収 / FABP
Research Abstract

The aim of this study was to clarify following two questions, 1.the functional difference between L - and I- FABP participating in the absorption of fatty acids in the small intestine. 2.The role of L - FABP in the colorectum, as to its affinity to carcinogens.
Methods and results are as follows ; 1.Quantitive measurement of the two FABP in duodenum, jejunum and ileum of five groups of rats, which were fed diets with high and low fat contents during two or four weeks, was carried out by SRID method. Jejunum showed the highest content of both FABPs than ileulm and duodenum. Only in the jejunum, L-FABP significantly increased in high fat diet group while I-FABP increased in the ileum and jujunum. Both FABPs concentration showed no difference between in low fat diet group and normal cotrols. These findings support the concept that FABPs are inducted by high fat intake, and those have different roles in fatty acid absorption and transport. 2.The intensity of L-FABP immunostaining vy PAP mothod with anti-FABP antivodies was studied in 82 patients with advanced colorectal cancer. The untensity of FABP immnunostaining varied significantly with the histologic type, node metastasis, and histologic stage of colorectal cancer. The cumulative postoperative survival rate was siginificantly higher in the patients with high intensity FABP immunostaining than in those with low intensive staining both in the entire series and in a series of 60 patients with curative resection (p<0.001).These results suggest that the intensity of FABP immunostaining might indicate a prognostic role in patients with advanced colorectal cancer.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 村上博史,酒井靖夫ほか: "飼料中の脂肪含有量の差異に対するラット腸管L-FABP濃度の変動" 消化と吸収(日本消化吸収学会雑誌). 15(2). 128-131 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 太田一寿: "進行大腸癌における脂肪酸結合蛋白の免疫組織学的検討" 新潟医学会雑誌. 106(4). 310-321 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 村上博史,酒井靖夫ほか: "ラット腸管のI-FABP濃度と、脂肪含有量の異なる食餌摂取に対するI-FABP濃度の変動" 消化と吸収(日本消化吸収学会雑誌). 16(2). 61-65 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hirochi, Murakami et.al.: "Changes in the concentration of L-FABP in rat intestine following feeding diets of varying fat contents" Digestion & Absorption. 15. 128-131 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hiroshi, Murakami et.al.: "Concentration of I-FABP in rat intestine and changes in I-FABP following feeding diets of varying fat contents" Digestion & Absorption. 16. 61-65 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kazutoshi, Ohta: "Immunohistological study of fatty acid binding protein in advanced colorectal cancer. Comparison of intensity of FABP immunostaining with clinicopathological factors and DNA ploidy pattern" Niigata Med.J. 106. 310-321 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 村上博史,酒井靖夫ほか: "飼料中の脂肪含有量の差異に対するラット腸管L-FABP濃度の変動" 消化と吸収(日本消化吸収学会雑誌). 15(2). 128-131 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 太田一寿: "進行大腸癌における脂肪酸結合蛋白の免疫組織学的検討" 新潟医学会雑誌. 106(4). 310-321 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 村上博史,酒井靖夫ほか: "ラット腸管のI-FABP濃度と、脂肪含有量の異なる食餌摂取に対するI-FABP濃度の変動" 消化と吸収(日本消化吸収学会雑誌). 16(2). 61-65 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 村上 博史 酒井 靖夫ほか: "飼料中の脂肪含有量の差異に対するラット腸管L-FABP濃度の変動" 消化と吸収(日本消化吸収学会雑誌). 15(2). 128-131 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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