| Project/Area Number |
04454341
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | National Cardiovascular Center Research Institute (1993-1994)
Tokyo Medical and Dental University (1992) |
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Principal Investigator |
TSUJI Takayuki National Cardiovascular Center Research Institute Department of Surgical Research Director, 実験治療開発部, 部長 (00075764)
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| Co-Investigator(Kenkyū-buntansha) |
MASUZAWA Tooru National Cardiovascular Center Research Institute Department of Artificial Organ, 人工臓器, 室員 (40199691)
MIYAWAKI Fujio National Cardiovascular Center Research Institute Department of Surgical Researc, 実験治療開発部, 室長 (50174222)
赤城 治彦 国立循環器病センター研究所, 人工臓器部, 研究室員 (90231802)
佐田 正晴 国立循環器病センター研究所, 実験治療開発部, 研究室員 (20162399)
岩田 博夫 国立循環器病センター研究所, 実験治療開発部, 室長 (30160120)
谷下 一夫 慶應大学, 理工学部, 教授 (10101776)
斎藤 浩一 東京医科歯科大学, 医用器材研究所, 教務職員 (00205668)
川原田 淳 東京医科歯科大学, 医用器材研究所, 助手 (80195164)
戸川 達男 東京医科歯科大学, 医用器材研究所, 教授 (40013859)
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| Project Period (FY) |
1992 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 1994: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1993: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1992: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | hyperbaric oxygenator / blind-ended silastic hollow fiber / ultrasonic bubble detector / intracaval oxygenator / gas pressure regulator / 高圧酸素 / 高圧型酸素 / 酸素付加専用型高圧人工肺 / キャピラリ人工肺 / 酸素ガス輸送 / 超音波気泡検出器 / バブル / 内挿型人工肺 / シリコーンホローファイバ / 大静脈内留置型人工肺システム / 気液両相型人工肺 / ハイドロキシアパタイト皮膚端子 / 多機能型小型人工肺 / 植え込み型人工肺 |
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| Research Abstract |
Development of an intracorporeal silastic hollow fiber membrane oxygenator capable of indwelling in caval vein was attempted for exclusive use of oxygenation for long term respiratory assist.
A blind-ended silastic hollow fiber oxygenator was infused extracapillarily with hyperbaric oxygen controlled by a gas pressure regulator driven with voltage output fed back with signal from an ultrasonic bubble detector placed on the downstream blood tubing in order to prevent oxygen bubbling which appears in oversaturated state due to hyperbaric oxygenation. The system could keep maximal oxygenation without bubble appearance by feed-back circuit in a mock circulation.
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