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Development of a Silastic Hollow Fiber Oxygenator Driven with a Hyperbaric Oxygen Pressure Controller with an Ultrasonic Bubble Detector

Research Project

Project/Area Number 04454341
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionNational Cardiovascular Center Research Institute (1993-1994)
Tokyo Medical and Dental University (1992)

Principal Investigator

TSUJI Takayuki  National Cardiovascular Center Research Institute Department of Surgical Research Director, 実験治療開発部, 部長 (00075764)

Co-Investigator(Kenkyū-buntansha) MASUZAWA Tooru  National Cardiovascular Center Research Institute Department of Artificial Organ, 人工臓器, 室員 (40199691)
MIYAWAKI Fujio  National Cardiovascular Center Research Institute Department of Surgical Researc, 実験治療開発部, 室長 (50174222)
赤城 治彦  国立循環器病センター研究所, 人工臓器部, 研究室員 (90231802)
佐田 正晴  国立循環器病センター研究所, 実験治療開発部, 研究室員 (20162399)
岩田 博夫  国立循環器病センター研究所, 実験治療開発部, 室長 (30160120)
谷下 一夫  慶應大学, 理工学部, 教授 (10101776)
斎藤 浩一  東京医科歯科大学, 医用器材研究所, 教務職員 (00205668)
川原田 淳  東京医科歯科大学, 医用器材研究所, 助手 (80195164)
戸川 達男  東京医科歯科大学, 医用器材研究所, 教授 (40013859)
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 1994: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1993: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1992: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordshyperbaric oxygenator / blind-ended silastic hollow fiber / ultrasonic bubble detector / intracaval oxygenator / gas pressure regulator / 高圧酸素 / 高圧型酸素 / 酸素付加専用型高圧人工肺 / キャピラリ人工肺 / 酸素ガス輸送 / 超音波気泡検出器 / バブル / 内挿型人工肺 / シリコーンホローファイバ / 大静脈内留置型人工肺システム / 気液両相型人工肺 / ハイドロキシアパタイト皮膚端子 / 多機能型小型人工肺 / 植え込み型人工肺
Research Abstract

Development of an intracorporeal silastic hollow fiber membrane oxygenator capable of indwelling in caval vein was attempted for exclusive use of oxygenation for long term respiratory assist.
A blind-ended silastic hollow fiber oxygenator was infused extracapillarily with hyperbaric oxygen controlled by a gas pressure regulator driven with voltage output fed back with signal from an ultrasonic bubble detector placed on the downstream blood tubing in order to prevent oxygen bubbling which appears in oversaturated state due to hyperbaric oxygenation. The system could keep maximal oxygenation without bubble appearance by feed-back circuit in a mock circulation.

Report

(4 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report

Research Products

(31 results)

All Other

All Publications

  • [Publications] 辻 隆之,徳野慎一,菅 伊知郎: "術中・術後体温計測の意義とその応用" クリニカルエンジニアリング. 4. 321-326 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 辻 隆之,宮脇富士夫,赤城治彦,妙中義之,高野久輝: "わが国における人工肺の現状と将来" 医器誌. 63. 451-457 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 辻 隆之,川原田 淳,藤元登四郎,千田彰一,松尾裕英,戸川達男: "テイルフィン付き水晶温度センサの開発と超音波法による臓器血流推定法の実験的検討" 臨床体温. 14. 85-89 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 辻 隆之,野城真理,今井庸二,菰田泰夫,藤元登四郎,戸川達男: "MMAモノマーの静脈内投与のイヌに対する急性毒性の検討" 医器材研報. 40-45 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 辻 隆之,宮脇富士夫,橋本大定,福与恒雄,井筒 岳,葛西 猛: "スタイレット喉頭内視鏡気管内青有漢システムの開発" 医器誌. 64. 219-222 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 辻 隆之,宮脇富士夫,川口 章,向井藤夫,橋本大定,福与恒雄: "細口径(外径6.5mm)立体視硬性内視鏡システムの開発" 医器誌. 65. 32-35 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 辻 隆之: "体温計(深部温度計)須磨幸蔵,城間賢二編「手術室の設計・整備・機器・運営」" 日本プランニングセンター 東京, 272 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 辻 隆之,赤城治彦,谷下一夫: "模型人工肺の評価,人工臓器1994-95" 中山書店 東京, 312 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Takayuki Tsuji, Fujio Miyawaki, Haruhiko Takagi, Yoshiyuki Taenaka, Hisateru Takano: "Current status its future of artificial lung in our country (in Japanese)" Japn J Med Instr. 63 (10). 451-457 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Takayuki Tsuji, Fujio Miyawaki, Daijo Hashimoto, Tuneo Fukuyo, Takeshi Izutsu, Takeshi Kasai: "Development of a fiber-optical stylet laryngoscope with CRT monitor (in Japanese with English abstruct)" Japn J Med Instr. 64 (5). 219-222 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hiroo Iwata, Tatsuya Takagi, Kazuo Kobayashi, Takayuki Oka, Takayuki Tsuji, Fumiaki Ito: "Strategy for developing microbeads applicable to islet xenotransplantation into a spontaneous diabetic NOD mouse" J Biomed Matr Research. 28. 1201-1207 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hiroo Iwata, Kauo Kobayashi, Tatsuya Takagi, Takayuki Oka, Hua Yang, Hiroshi Amemiya, Takayuki Tsuji, Fumiaki Ito: "Feasiblity of agarose microbeads with xenogeneic islets as a bioartificial pancreas" J Biomed Matr Research. 28. 1003-1011 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Takayuki Tsuji, Makoto NOshiro, Yohji Imai, Yasuo Komoda, Toshiro Fujimoto, Tatsuo Togawa: "Acute intoxication of methyl methacrylate (MMA) monomer administered intravenously into dogs (in Japanese with English abstruct)" Reports of the Institute for Medical and Dental Engineering. 28. 40-45 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Takayuki Tsuji, Takanobu Hoshino, Toshiro Fujimoto, Tatsuo Togawa, Tsuyoshi Ohshima: "Implantation of ultrasonic coupling quartz crystal resonators into animal and human organs for organ temperature monitoring (in Japanese with English abstruct)" Japn J Clin Monitoring. 3 (5). 451-458 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Takayuki Tsuji, Yasuhiro Fukui, Hirokazu Saito, Tatsuo Togawa, Kozo Suma: "Intraoperative assesment of the corredtive surgery of tetralogy of Fallot" Computing and Monitoring in Anesthesia and Intensive Care-Recent Technology Advances ed. by K Ikeda, M Doi, T Kazama, K Sato, T Oyama, Springer-Verlag. 475-476 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Takayuki Tsuji, Haruhiko Akagi, Kazuo Tanishita: Determination of membrane resistance for evaluation of membrane oxygenators with in vitro experiments, Artificialtakayu Organs' 1994-5-Annual Review. Nakayama Shoten, in Japanese with English abstruct, 210-215 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 辻 隆之,川原田 淳,藤元登四郎,千田彰一,松尾裕英,戸川達男: "テイルフィン付き水晶温度センサの開発と超音波法による臓器血流推定法の実験的検討" 臨床体温. 14. 85-89 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 辻 隆之,野城真理,今井庸二,蔵田泰夫,藤元登四郎,戸川達男: "MMAモノマーの静脈内投与のイヌに対する急性毒性の検討" 医器材研報. 40-45 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 辻 隆之,宮脇富士夫々,本大定,福与恒雄,井筒 岳,葛西 猛: "スタイレット喉頭内視鏡気管内青有漢システムの開発" 医器誌. 64. 219-222 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 辻 隆之: "医療機器としてのわが国の体温計の現状と将来" 臨床体温. 14. 18-22 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 辻 隆之,宮脇富士夫,川口 肇,向井藤夫,橋本大定,福与恒雄: "細口径(外形6.5mm)立体視硬性内視鏡システムの開発" 医器誌. 65. 32-35 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 辻 隆之: "超微細管粘度計測法とアルブミン分子の変形性" 第17回大阪大学BME研究会コロキアム. 27-30 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 辻 隆之,赤城治彦,谷下一夫: "膜型人工肺の評価,人工臓器1994-95" 中山書店 東京, 312 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 辻 隆之,星野高伸,藤元登四郎,大島 剛,戸川達男: "水晶温度センサを用いた肝臓および腎臓温テレメトリに関する実験的検討ー移植腎拒絶反応モニタリングを目指してー" 臨床モニター. 3(5). 451-458 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 辻隆之,井筒岳,本保秀三,長田一仁,太斎公隆,藤元登四郎,戸川達男: "超音波検出法によるステンレス鋼カプセル性微小水晶体温センサの臨床応用に関する研究" 医器材研報. 26. 51-55 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tsuji T,Fujimoto T,Togawa T: "T1 evaluation of the effect of methylprednisolone on canine intracerebral hematoma" SMRM Book of Abstracts. Vol1. 1013- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tsuji T,Fujimoto T,Togawa T,Ohshima T: "Development of an implantable quartz thermosensor for organ temperature monitoring using ultrasonic detection" Proceedings of 14th Ann Int'l Conf of IEEE. 14. 2421- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 辻 隆之: "わが国の先進医療機器開発について" 医器学. 62(6). 300-305 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 辻 隆之,宮脇富士夫,妙中義之,高野久輝: "わが国における人工心肺装置とその付属機器,および人工肺の現状と将来" 医器誌. 発行予定. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 辻 隆之,須磨幸蔵: "生体情報と計測,人工臓器とME機器,出月康夫,古瀬 彰,杉町圭蔵編,「NEW外科学」" 南江堂,東京, 161-175 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 辻 隆之: "体温計(深部温度計)須磨措蔵,城間賢二編,「手術室の設計・整備・機器・運営」" 日本プランニングセンター,東京, 148-152 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-03-31   Modified: 2016-04-21  

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