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Research of morphological, biochemical, biomechanical change of peripheral nerve in aging

Research Project

Project/Area Number 04454379
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

HIRASAWA Yasusuke  Kyoto Prefectural University of Medicine, Department of Orthopaedic Surgery, Chairman of Orthopaedic Surgery, 医学部, 教授 (40079851)

Co-Investigator(Kenkyū-buntansha) TAKAI Shinro  Kyoto Prefectural University of Medicine, Department of Orthopaedic Surgery, Ass, 医学部, 助手 (10226730)
TAMAI Kazuo  Kyoto Prefectural University of Medicine, Department of Orthopaedic Surgery, Ass, 医学部, 講師 (80227256)
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 1994: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1993: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1992: ¥3,300,000 (Direct Cost: ¥3,300,000)
KeywordsBrachial plexus / acryl plastic injection method / microcorrosion cast / scanning electron microscope / extrafascicular capillaries / intrafascicular capillaries / aging / 内血管系 / アクリル樹脂注入法 / 微細血管鋳型標本 / 走査電子顕微鏡 / 神経束外血管系 / 神経束内血管系 / 牽引-損傷
Research Abstract

1. Japanese white rabbits were divided into three groups based on their age ; immature groups (4-6 months), mature groups (less than 36 months), aged groups (more than 36 months). The rabbit sciatic nerves were loaded to failure in tension. Load-deformation curves and stress-strain curves were evaluated. The stiffness and tensile strength of imature groups were samller than the mature and aged groups. But there were no significant differences between each groups in mechanical properties.
2. The brachial plexus of Japanese white rabbits were surgically exposed under intravenous anesthesia. Each rabbit brachial plexus was stretched laterally up to electrophysiological failure to conduct. The distance between two marks placed on the lower trunks was simultaneously recorded with a video dimensional analysis system. In results, the nerve strain, load and stress at complete conduction block were found to be 8.5%, 2.6N,1MPa, respectively.
3. Microvascular architecture of brachial plexus in the Japanese monkey was examined by means of acryl plastic injection method (Ohta et al. 1990) using microcorrosion casts in scanning electron microscope. The extrafascicular capillaries of the brachial plexus were rarely observed, but the intrafascicular capillaries were developped with dense blood supply. Distribution of blood vessels in the brachial plexus was border of segmental blood supply especially under the clavicle.

Report

(4 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 堂埜 秀文: "抹梢神経の引張り特性に関する実験的研究" 整形外科バイオメカニクス. 13. 229-232 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 柴田 節子: "抹梢神経自家移植術後の微細血管再構築に関する実験的研究" 京都府立医大雑誌. 102. 1101-1116 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 堂埜 秀文: "腕神経叢索引損傷の生体力学的検討" 日本臨床バイオメカニクス学会誌. 14. 449-452 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hidefumi Dohno: "The influence of age difference and tensile speed on mechanical properties of peripheral nerve in tension." proceedings of 1991 Annual Meeting of Japanese Society for Orthopaedic Biomechanics. 13. 229-232 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Setsuko Shibata: "Experimental study on revascularization of peripheral nerve autograft in the rabbit sciatic nerve" Journal of Kyoto Prefectural University of Medicine. 102. 1101-1116

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hidefumi Dohno: "Biomechanical analysis of brachial plexus stretch injury" Proceedings of 1992 Annual Meeting of Japanese Society for Orthopaedic Biomechanics. 14. 449-252 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 堂埜秀文: "腕神経叢の微細血管分布に関する研究" 日本整形外科学会雑誌. 63. S1399 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 堂埜 秀文: "末梢神経の引張り特性に関する実験的研究" 整形外科バイオメカニクス. 13. 229-232 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 堂埜 秀文: "腕神経叢牽引損傷の生体力学的検討" 日本臨床バイオメカニクス. 14. 91-94 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 柴田 節子: "末梢神経自家移植術後の微細血管再構築に関する実験的研究" 京都府立医科大学雑誌. 102. 1169-1181 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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