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Fundamental and Clinical Study to Establish Indications and the Safety of a Life Support System with an Artificial Lung

Research Project

Project/Area Number 04454390
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 麻酔学
Research InstitutionKUMAMOTO UNIVERSITY SCHOOL OF MEDICINE

Principal Investigator

MORIOKA Tohru  Kumamoto University School of Medicine, Dept of Anesthesiology Professor, 医学部, 教授 (30040140)

Co-Investigator(Kenkyū-buntansha) USHIJIMA Kazuo  Kumamoto University School of Medicine, Dept of Anesthesiology Ihstructor, 医学部附属病院, 講師 (60136752)
TERASAKI Hidenori  Kumamoto University School of Medicine, Dept of Anesthesiology Associate Profess, 医学部, 助教授 (30040562)
松田 史彦  熊本大学, 医学部・附属病院, 助手 (50244140)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 1993: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1992: ¥5,000,000 (Direct Cost: ¥5,000,000)
KeywordsArtificial Heart Lung Machine / Membrane Lung / Life Support / Indications / ECLS / Anticoagulant / Instrumentation / Extracorporeal Circulation / 抗凝固薬
Research Abstract

The life support system with an artificial heart-lung machine, which we call ECLS instead of ECMO, has becom more and more popular. Various research societies have been established for the study of this new modality of medicine. However. indications of ECLS have not been well established. Though there are standards or entry criteria for ECMO, they only indicate critical conditions with a survival expectancy of less than 10%. They do not necessarily represent the indications for ECLS.
We have improved various bypass methods and instruments for facility and safety of ECLS.
They include the artificial hollow fiber lung, quick connectors, blood accesses, pressure control devices, automating mechanics of bypass circulation according to the blood volume in the reservoir, etc. Bypass circulation is continued for several days without difficulty after improvement with such devices. Blood loss has been markedly decreased by applying nafamostat mesilate instead of heparin. The safety of the prolonged use of this drug was confirmed by animal experiments and clinical application of the drug.
We have had 59 cases of ECLS with a survival rate of about 50%. Though this ratio is not large enough, these patients were saved from a critical condition where their life expectancy was almost zero even under maximal conventional ventilation.
With this experience, we established indications for ECLS, published them in several journals and presented them for discussion in many conferences on ECLS held in various countries. The life support with an extracorporeal bypass system will become an important new field of medicine in the next decade.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] Okamoto,Taisuke: "Experimental results using nefamostat mesilate as anticoagulont during extracovporeal lung assist for 24 hours in dogs." Artif. Organs. 17. 30-36 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tsuno,Kyouji: "New form extracovporeal lung assist using a novel double lumen cathcter and a beparinbonded membrane lung." Intensive Care Medicine. 19. 70-72 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 森岡 亨: "人工肺を用いる生命維持法の現状と将来" 臨床麻酔. 17. 581-589 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kano,Tatsuhiko: "Cardiopulmonary-cerebral resascitation by using cardiopulmonary bypass through the fermoral vein and artery in dogs." Resuscitation. 25. 265-281 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 森岡 亨: "人工心肺と救急蘇生" 日医新報. 3618. 12-22 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 橋口 清明: "緊急心肺バイパスによる心肺脳蘇生法の研究(3)神経学的予後ならびに脳の病理変化" 麻酔. 42. 1451-1458 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 森岡 享: "人工臓器(植え込み型人工肺の章)" 中山書店, 322 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Otsu T,Terasaki H,Choi H Tajiri A Okamoto T Matsuyama K Morioka T: "Gas-exchange function of a preprimed pediatric oxy-genator stored for one year for emergency cardiopulmonary bypass." Artif Organs. 16. 502-504 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kano T,et al and Morioka T: "Cardiopulmonary-cerebral resuscitation by using cardiopulmonary bypass through the femoraal vein and artery in dogs." Resuscitation. 25. 265-281 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Okamoto T Chung YK Choi H Terasaki H Morioka T: "Experimental results using nafamostat mesilate as anticoagulant during extracorporeal lung assist in dogs." Artif Organs. 17. 30-36 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kurose M Okamoto K Sato T Yasuda R Ogata K Yasumoto M Terasaki H Goto H Okumura K: "Successful treatment of life-threatening ventricular tachycardia with high-dose propranolol under extracorporeal life support and intraaortic balloon pumping." Jpn Circ J. 57. 1106-1110 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tsuno K Terasaki H Otsu T Okamoto T Sakanashi Y Morioka T: "Newborn extracorporeal lung assist using a novel double lumen catheter and a heaparin-bonded membrane lung." Intensive Care Med. 19. 70-72 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kurose M Okamoto K Sato T Ogata K Yasumoto M Terasaki H Morioka T: "Extracorporeal life support for patients undergoing prolonged external cardiac massage." Resuscitation. 25. 35-40 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Otsu T Terasaki H Tajiri A Okamoto T Choi H Tang SR Coto K Sakanashi Y Mizoguchi S Natsuyama K Matsumura H Yanagi F Morioka T: "A preprimed circuit stored for 45 days and used for emergency extracorporeal lung and heart assist." Crit Care Med. 21. 1795-1797 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Taisuke Okamoto, Suzuhiko Mizoguchi, Hidenori Terasaki, Tohru Morioka: "Safety of high-dose nafamostat mesilate toxicologcal study in beagles." J Pharm Experim Therap. 288. 639-644 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yuji Sakanashi, Hidenori Terasaki, Akihiro Tajiri, Suzuhiko Mizoguchi, Ik-Soo Chung, Kazufumi Okamoto, Tohru Morioka: "A case of Eisenmenger's syndrome treated with extracorporeal lung and heart assist in the postpartum period." J Anesth. 8. 107-109 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Okamoto,Taisuke: "Experimental resolts using nefamnetat mesilate as anticoagulont during extracovporeal lung assist for 24hours in dogs." Artif Organs. 17. 30-36 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Tsuno,Kyouji: "New born extracouporeal lung assist using a novel double lumen catheter and a beparinbondeet membrans lung." Intensive Care Medicine. 19. 70-72 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 森岡亨: "人工肺を用いる生命維持法の現状と将来" 臨床麻酔. 17. 581-589 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kano,Tatsuhiko: "Cardiopulmonary-cerebral resascitation by using cardiopulmonary bypass through the femoral vein and artrty in dogs." Resusaitation. 25. 265-281 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 森岡亨: "人工心肺と救急蘇生" 日医新報. 3618. 12-22 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 橋口清明: "緊急心肺バイパスによる心肺脳蘇生法の研究(3)神経学的予後ならびに脳の病理変化" 麻酔. 42. 1451-1458 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 森岡亨: "人工臓器(植え込み型人工肺の章)" 中山書店, 322 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kurose M.: "Extracorporeal life support for patient undergoing prolonged external cardiac massage" Resuscitation. 25. 35-40 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 丁 益秀: "ECMOの保守管理" Clinical Engeneering. 4. 1119-1126 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 田尻 晃彦: "長期体外式心肺補助法を用いて救命した難治性心室頻拍症例" 麻酔. 41. 1788-1792 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 森岡 亨: "ヘパリン結合緻密膜中空糸外部潅流式人工肺の新生児ECLAへの応用" 膜型肺. 15. 69-72 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 大津 哲郎: "幼児重症呼吸不全に対する38日間の長期ECLAの経験" 膜型肺. 15. 73-79 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 寺崎 秀則: "膜型人工肺と部分体外循環による生命維持法(Extracorporeal life support)の基礎的,臨床的研究" 人工臓器. 21. 38-42 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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