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Analysis of Immunological Changes during Anesthesia and Surgery

Research Project

Project/Area Number 04454393
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 麻酔学
Research InstitutionKYOTO PREFECTURAL UNIVERSITY OF MEDICINE

Principal Investigator

HOSOKAWA Toyoshi  KYOTO PREFECTURAL UNIVERSITY OF MEDICINE MEDICINE ASSOCIATE PROFESSOR, 医学部, 助教授 (80165555)

Co-Investigator(Kenkyū-buntansha) 藤原 昭宏  京都府立医科大学, 医学部, 助手 (90238626)
中川 博美  京都府立医科大学, 医学部, 助手 (00237231)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥5,900,000 (Direct Cost: ¥5,900,000)
Fiscal Year 1993: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1992: ¥4,200,000 (Direct Cost: ¥4,200,000)
KeywordsANESTHESIA / OPERATION / IMMUNE / STRESS / SYMPATHETIC NERVE SYSTEM / REFLEX SYMPATHETIC DYSTROPHY / PAIN / 手術侵襲 / コルチゾール / リンパ球 / 細胞性免疫
Research Abstract

(1) Stress during Surgery and Immunological Reaction
General anesthesia with epidural block or splanchnic nerve block inhibit the immuno-depressive changes during major surgery anesthetized with inhalation anesthesia itself or NLA.
(2) Stress during Surgery and Plasma Cortisol Concentration
General anesthesia with epidural block never depressed the increase of plasma cortisol concentration during upper abdominal surgery. The planchnic nerve block depressed the increase of plasma cortisol concentration significantly.
(3) Aggregation
Nevertheless, perioperative stress might have a relative influence on Platelet Aggregation, we have no adeguate method for evaluating the platelate function. We concluded that the new platelate aggregation test is essential.
(4) Sympathetic Nerve System
Sympathetic Nerve System has the function to conduct an impulse from the hypothalamus to the endocrine or immune system caused by stress, including pain stress. Quantitative analysis of pain can be evaluated by monitoring changes in the skin blood flow and sweating. We utilized this method and evaluated the sympathetic nerve system responce to pain stimulation during surgery.
(5) Reflex Sympathetic Dystrophy (RSD)
The new therapeutic procedure in our pain relief clinic and prevailing tharapy were evaluated in twenty RSD patients. We showed how the new method evaluated the pain in RSD patients, utilizingguantitive analysis by monitoring changes in the skin blood flow.
(6) Stellate Ganglion Block (SGB)
Stellate Ganglion distributed to the upper extrimities, face and head. We evaluated the influence of SGB to the periferal blood circulation.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] 青木祐司: "止血能の術前検査としての血漿板凝集能の新しい評価法-第一報-" 麻酔. 41. 561-565 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 青木祐司: "止血能の術前検査としての血漿板凝集能の新しい評価法-第二報-" 麻酔. 41. 909-913 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 大森美佐子: "上肢における星状神経ブロックの効果判定-手掌皮膚血流,皮膚温および精神性発汗量の検討-" ペインクリニック. 14. 693-697 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 中川博美: "侵害刺激による皮膚血流および精神性発汗量の変化" ペインクリニック. 14. 825-829 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 細川豊史(共著): "The Pain Clinic IV" M.Hyodo,T.Oyama,M.Swerdlow,VSP, 355 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 細川豊史(共著): "“代謝"臨時増刊号「漢方薬」-その医薬学的研究の最先端-" 奥田拓殖 他,中山書店, 470 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hiroshi AOKI: "A New Preoperative Evaluation of Aggregation -Part I-" Japanese Journal of Anesthesiology. vol.4(7). 561-565 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hiroshi AOKI: "A New Preoperative Evaluation of Aggregation -Part II-" Japanese Journal of Anesthesiology. vol.4(7). 909-913 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Misako OMORI: "Evaluation of Stellate Ganglion Block On Upper Extremity" Pain Clinic. vol.14(5). 693-697 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hiromi NAKAGAWA: "Changes in Skin Blood Flow and Perspiration Eliciated with Noxcious Stimuli" Pain Clinic. Vol.14(6). 825-829 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Toyoshi HOSOKAWA: "Management of Twenty Patients with Reflex Sympathetic Dystrophy Syndrome" The Pain Clinic IV. 263-268 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Toyoshi HOSOKAWA: "Anesthetic and Chinese Herbs" Metabolism and Disease. Vol, 29. 118-129 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 青木 祐司: "止血能の術前検査としての血漿板凝集能の新しい評価法-第1報-" 麻酔. 41. 561-565 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 青木 祐司: "止血能の術前検査としての血漿板凝集能の新しい評価法-第2報-" 麻酔. 41. 909-913 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 大森 美佐子: "上肢における星状神経ブロックの効果判定-手掌皮膚血流、皮膚温および精神性発汗量の検討-" ペイン・クリニック. 14. 693-697 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 中川博美: "侵害刺激による皮膚血流および精神性発汗量の変化" ペインクリニック. 14. 825-829 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 細川豊史(共著): "The Pain Clinic IV" M.Hyodo,T.Oyama and M.Swerdlow(Echtor)VSP(出版社), 355 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 細川豊史(共著): "“代謝"臨時増刊号「漢方薬」-その医療学的研究の最先端-" 奥田拓殖他:中山書店, 470 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 青木 祐司: "止血能の術前検査としての血しょう板凝集能の新しい評価法ー第1報ー" 麻酔. 41. 561-565 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 青木 祐司: "止血能の術前検査としての血しよう板凝集能の新しい評価法ー第2報ー" 麻酔. 41. 900-913 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 細川 豊史: "ドイツ連邦共和国のペインクニリック" ペインクリニック. 13. 740-744 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 細川 豊史: "麻酔薬ー麻酔薬と漢方薬,その医薬守的研究の最先端ー" 代謝 増刊号. 29巻. 118-123 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.HOSOKAWA: "Manayement of Twenty Patients with Reflex Sympathetic Dystrocphy Syndrome" The Pain clinic. 4. 263-268 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 大森 美佐子: "上肢における星状神経節ブロックの効果判定" ペインクリニック. 14. 154-160 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 細川 豊史: "耳鼻科診療Q&A" 六法出版, 6 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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