• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Protective effects of adenosine on acute myocardial ischemia

Research Project

Project/Area Number 04454395
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 麻酔・蘇生学
Research InstitutionUNIVERSITY OF TEIKYO MEDICAL SCHOOL

Principal Investigator

INADA Eiichi  Dept.of Anesthesia UNIVERSITY OF TEIKYO MEDICAL SCHOOL Professor, 医学部, 助教授 (40193552)

Co-Investigator(Kenkyū-buntansha) YAHAGI Mayumi  Dept.of Anesthesia UNIVERSITY OF TEIKYO MEDICAL SCHOOL Professor., 医学部, 助手 (20211617)
OKADA Kazuo  Dept.of Anesthesia UNIVERSITY OF TEIKYO MEDICAL SCHOOL Professor, 医学部, 教授 (30082093)
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1994: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
Keywordsadenosine / myocardial ischemia / beta-receptor / coronary blood flow / Emax / ベータ受容体
Research Abstract

Adult mongrel dogs were anesthetized with pentobarbital and enflurane in air. A hydraulic snare was applied over the left anterior descending artery to make a critical stenosis. In the hypotensive period, adenosine 100 mcg/kg/min was infused. Blood pressure was significantly decreased with a significant decrease in systemic vascular resistance (SVR). Cardiac output was increased with no change in Emax. When adenosine was given during myocardial ischemia, cardiac output, Emax were better maintained in adenosine-treated dogs than in the control group. After completion of the 60 min of ischemic period, the heart was excised and resected in ischemic and non-ischemic areas. The intracellular concentrations of adenosine, adenosine diphosphate, adenosine triphosphate, and beta-receptor density on the myocytes were measured using HPLC and H3-dihydroalprenol (DHA) binding assay respectively. There were no significant differences in high-energy phosphates concentrations and beta-receptor density between adenosine-treated myocardium and the control myocardium.
The results suggested that adenosine preserved the myocardial pump function secondary to the decreased afterload in acute ischemic heart. Preservation of the intracellular high-energy phosphates and beta-receptor density probably did not play an important role to maintain cardiac systolic function in this canine model.

Report

(4 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 奥村福一郎: "循環管理法" 日本臨床麻酔学会誌. 14. 227-243 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 稲田 英一: "麻酔への知的アプローチ第3版" 日本医事新報社, 400 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Eiichi Inada, Kazuo Okada, Mayumi Yahagi: "Protective effects of adenosine on acute myocardial ischemia" Byoutaiseiri. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Fukuichiro, Okumura, Eiichi Inada, et al: "Circulatory management." J Japan Soc Clin Anesth. 14 (3). 227-243 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 奥村福一郎: "循環管理法" 日本臨床麻酔学会誌. 14. 227-243 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 稲田英一: "麻酔への知的アプローチ第3版" 日本医事新報社, 400 (1995)

    • Related Report
      1994 Annual Research Report

URL: 

Published: 1993-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi