• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecularbiological studies of the mechanism on the abnormal prostatic growth : Epithelial-mesenchymal interaction

Research Project

Project/Area Number 04454401
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionMie university

Principal Investigator

KAWAMURA Juichi  Mie University・Faculty of Medicine, Professor., 医学部, 教授 (70026839)

Co-Investigator(Kenkyū-buntansha) ARIMA Kiminobu  Mie University, University Hospital, Assistant., 医学部・附属病院, 助手 (10175995)
KINBARA Hiroyuki  Mie University, University Hospital, Assistant., 医学部・附属病院, 助手 (40225123)
HAYASHI Norio  Mie University・Faculty of Medicine, Assistant., 医学部, 助手 (70198852)
杉村 芳樹  医学部附属病院, 講師 (90179151)
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥7,300,000 (Direct Cost: ¥7,300,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1993: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1992: ¥5,300,000 (Direct Cost: ¥5,300,000)
KeywordsEpithelial-mesenchymal interaction / Recombination / Urogenital sinus mesenchyme / Cell growth / Secretory protein / Dunning rat tumor / Organ culture / Keratinocyte Growth Factor / 上皮-間質相互作用 / 合成エストロゲン / 異常前立腺腺管 / テストステロン代謝
Research Abstract

(1) The fetal urogenital sinus mesenchyme induced all prostatic secretory proteins product as well as the prostatic epithelial growth on any adult rodent prostatic lobes via epithelial-mesenchymal interaction. We examined the role of Keratinocyte growth factor (KGF) for prostatic development with mouse prostatic organ culture system using the serum free conditioning medium. That results suggested the role of KGF as a paracrine mediator for epithelial cells, which was produced by mesenchymal cells.
(2) Neonatal seminal vesicle mesenchyme elicited the reduction of growth rate and the changes of epithelial morphology, secretory protein molecular weight and testosterone metabolic pattern on Dunning rat prostatic carcinoma. Such like induced characteristics were similar to those of normal prostate or seminal vesicle. These findings demonstrate that the connective tissue environment can have profound regulative effects on both normal and neoplastic epithelial cells. The paracrine mediators like a KGF might certainly augment our knowledge of the carcinogenic process and lead to new therapeutic strategies.

Report

(4 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] Hayashi N,et al,: "Permisssive and instruction induction of adult rodentprostatic epithelium by neterotypic urogenital sinus mesenchyme." Epithelial Cell Biology. 2. 66-78 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sugimura Y,et al,: "Age-related changes of the prostate gland in the senescence-accelerated mouse" Prostate. 24. 24-32 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamashita A, ET AL,: "Influence of β-diethylstilbestrol,Leuprolelin(an LH-RH analogue),Finasteride(a 5α-reductase inhibitor)and castration on the lobar subdivision of the rat prostate." Prostate. (accepted). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kinbara H,et al,: "Ductal heterogeneity in rat dorsal-lateral prostate" Prostate. (submitted). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hayashi n,et al,: "Morphological and functional oytodifferentation on the Dunning prostatic adenocarcinoma." (submitted). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sugimura Y,et al,: "Fundamental approaches to the diagnosis and treatment for prostate cancer and BPH" Imai K,Shimazaki J and Karr JP, 213 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hayashi N,et al.: "Permissive and instructive induction of adult rodent prostatic epithelium by heterotypic urogenital sinus mesenchyme." Epith Cell Biol.2. 66-78 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sugimura Y,et al.: "Age-related changes of the prostate gland in the senescence-accelerated mouse." Prostate.24. 24-32 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sugimura Y,et al.: "Mesenchymal-epithelial interactions in prostatic growth : Role of growth factors as androgenic signals. In : Fundamental approaches to the diagnosis and treatment for prostate cancer and BPH (Eds.by Imai K,Shimazaki J and Karr JP)" Adenine Press. 97-102 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hayashi N,et al.: "Morphological and functional cytodifferentiation on the Dunning prostatic adenocarcinoma." Prostate submitted. (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamashita A,et al.: "Influence of beta-diethylstilbestrol, Leuprolelin (an LH-RH analogue), Finasteride (a 5alpha-reductase inhibitor) and castration on the lobar subdivisions of the rat prostate." Prostate accepted. (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kinbara H,et al.: "Ductal heterogeneity in rat dorsal-lateral prostate" Prostate submitted. (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hayashi,etal.: "Permissive and instructive of adalt rodent prostatic epithelium by heterotypic urogenital sinus mesenchyme" Epithelial Cell Bidogy. 2. 66-78 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Sugimura Y,et al.: "Age-related changes of the prostate gland in the senescenceaccelerated mouse" Prostate. 24. 24-32 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Sugimura Y,et al.: "Fandamental approaches to the diagnosis and treatment for prostate cancer and BPH" Imai K,Shimazaki J and Karr JP, 213 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Arima K,Sugimura Y,Tochigi H,Kawamura J.: "Mean nuclear volume of bladder cancer:Streological estimation and its clinical value." Urol.Int.51. 62-66 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Sugimura Y.,Sakurai M,Hayashi N,Yamashita A,Kawamura,J.: "Age-related changes of the prostate gland in the senescence accelerated mouse(SAM)." Prostate. 24. 24-32 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kawamura,J.,Sakurai,M.,Tsukamoto,K.,et al.: "Leiomyosarcoma of the bladder eighteen years after cyclophosphamide therapy for retinoblastoma." Urol.Int.51. 49-53 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Cunha,G.R.Sugimura,Y.,Foster.B,Rubin JS,Aaronson SA.: "The role of growth factors in the development and growth of the prostate and seminal vesicle.In:Growth Factors and BPH." M.C.Andro(ed) Elsevier (in press),

    • Related Report
      1993 Annual Research Report
  • [Publications] 川村寿一: "最新内科学大系,第16巻性腺症患,VIホルモン依存性癌,β前立腺癌" 猿田享男,長瀧重信,松倉茂 編,中山書店, 334 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] N.Hayashi,GR.Cunha M.Parker: "Permissive and instructive induction of adult rodent prostatic cpithelium by heterotypic urogenital sinus mesenchyme" Epithelial Cell Biology.

    • Related Report
      1992 Annual Research Report
  • [Publications] YC.Wong,GR Cunha N.Hayashi: "Effects of mesenchyme of the embryonic urogenital sinus and neonatal seminal vesicle one the cytodifferentiation of the Duning tumor:Ultrastructural study" Acta Anatomica. 143. 139-150 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] WD.Laurence,D.Whitaker Y.Sugimura.et al.: "An ultrastructural study of the developing urogenital tract in early human fetuses" Am.J Obst.&Gyne.167. 185-193 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] GR.Cunha,E.Battle,P.Young N.Hayashi,H.Kinbara et al.: "Role of epithelial-mesenchymal interaction in the differentiation and spatial organization of visccral smooth muscle" Epithclial Cell Biology. 1. 76-83 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 川村 寿一: "前立腺癌の診断と治療の進歩" 第23回日本医学会総会会誌(小川和朗編). I. 78-79 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 川村 寿一: "前立腺癌の超音波" 新医療. 5(No.209). 62-65 (1992)

    • Related Report
      1992 Annual Research Report

URL: 

Published: 1992-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi