| Project/Area Number |
04454412
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
泌尿器科学
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| Research Institution | Nagoya City University (1994)
Kinki University (1992-1993) |
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Principal Investigator |
KOHRI Kenjiro Medical School, Nagoya City Univ.Department of Urology Professor, 医学部, 教授 (30122047)
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| Co-Investigator(Kenkyū-buntansha) |
UMEKAWA Tohru Kinki Univ.School of Medicine, Department of Urology Assistant, 医学部, 助手 (00232893)
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| Project Period (FY) |
1992 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1994: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1993: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Osteopontin / Urolithiasis / Calprotection / Genetic / Matrix / Calcium / Atheroscrelosis / 尿路結石症 / オステオポンチン(OPN) / OPN-mRNA / in situ hybridization / northern blot法 / 分子生物学 |
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| Research Abstract |
We have researched the pathogenesis of urolithiasis. We detected osteopontin and calprotectin as the matrix of urolithiasis and the expression of mRNA and protein of the materials was noted in the renal distal tubular cells, It is also known that the materials paly an important role in calcifications such as tartar and atheroscrelosis. Both of materials are produced from macrophage, which phagocytoses calcium oxalate and calcium phosphate.
Etiology of atherosclerosis is similar to that of urolithiasis. Namely, both diseases mostly exist in middle aged male and old female, and are increasing after World War II attendant upon the European diet. Macrophage, cytokine such as IL-1, TNF et.al were observed in stone forming kidney in rats as well as human being.
Based on these findings, it is reasonable to presume that the pathogenesis of urolithiasis is similar to that of atheroscrelosis.
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