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THE STUDY OF ETIOLOGY AND PATHOPHYSIOLOGY OF PREECLAMPSIA,ANALYSIS IN THE ASPECT OF INTRACELLULAR SIGNAL TRANSDUCTION

Research Project

Project/Area Number 04454419
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionKOBE UNIVERSITY

Principal Investigator

MOCHIZUKI Matsuto  Kobe University School of Medicine, Professor, 医学部, 教授 (80030922)

Co-Investigator(Kenkyū-buntansha) DEGUCHI Masaki  Kobe University School of Medicine, Lecturer, 医学部・付属病院, 助手 (70163938)
YAMASAKI Mineo  Kobe University School of Medicine, Lecturer, 医学部・付属病院, 講師 (00220301)
MARUO Takeshi  Kobe University School of Medicine, Associate Professor, 医学部・付属病院, 助教授 (60135811)
MORIKAWA Hajime  Kobe University School of Medicine, Associate Professor, 医学部, 助教授 (30030894)
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1993: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1992: ¥5,400,000 (Direct Cost: ¥5,400,000)
KeywordsPregnancy Induced Hypertension / Endothelin-1 / Platelet-Activating Factor / Hyperlipidemia / Fatty Acids / Nitric Oxide / Magnesium / IGF-1 / エンドセリン-1(ET-1) / 血小板活性化因子(PAF) / 妊娠高血圧症(PIH) / 血管内皮細胞 / エストラジオール / プレゲステロン / PAF-AH / ナトリウムイオン / カルシウムイオン / マグネシウムイオン / 液性因子 / エンドセリン
Research Abstract

1. Endothelial cell function : Pregnant women complicated with pregnancy-induced hypertension in severe type (severe PIH) showed increased plasma levels of endothelin-1 than did normal controls. Changes in fat metabolism were also observed in severe PIH as follows ; higher triglyceridemia with lower HDL-cholesterolemia, increased plasma saturated/unsaturated fatty acids ratio, increased plasma concentration of lipid-peroxide and decreased levels of plasma vitamin E.These are considered as factors intiating and/or deteriorating endothelial cell dysfunction. In vitro studies using cultured endothelial cells also demonstrated that altered profiles of sex steroids and that of lipids in the severe PIH are involved in the pathophysiology of the disorder. However, severe PIH patients also showed increased plasma concentration of platelet-activating factor, which has vasodilatory effect, suggesting that endothelium may still function to antagonize high blood pressure. Nitric oxide synthase of … More placental tissue in constitutive type was demonstrated to be equal on Western blot between normal pregnancy and severe PIH.Although the number of cases is small, there was a tendency of decreased urinary excretion of metabolites of nitric oxide in severe PIH.
2. Electrolytes metabolism : Concentrations of ionized Mgin whole blood and these of intracellular Mg were significantly lower in severe PIH than in normal controls, while there was no significant difference in serum Mg levels between the two groups. These suggest altered Mg metabolism exist in severe PIH.The results of MgSO4 loading revealed a relative deficiency in Mg in the disorder.
3. Fetal development : Plasma IGF-1 levels increased along the course of normal pregnancy correlating to fetal development and maternal weight gain. In severe PIH plasma concentrations of IGF-1 was extremely low in spite of maternal weight gain. This suggests change in IGF-1 reflects disorders in maternal circumstances in nutrition which is closely related to fetal growth. Less

Report

(4 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (66 results)

All Other

All Publications (66 results)

  • [Publications] Sri Kadarsih Soejono: "Maternal throid function and fetal growth in the endemic goiter area in Indonesia." Adv. Obstet Gynecol.46. 579-587 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 高島 正樹: "High-risk妊婦に対するlow-dose aspirin療法の試み" 日産婦誌. 44. 845-852 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 望月 眞人: "カレントレビュー、周産期-胎児発育" 日産婦誌. 44. 1059-1069 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 望月 眞人: "研修コーナー、胎盤機能の評価法" 日産婦誌. 44. N223-N226 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 望月 眞人: "カルシウム代謝" 日臨床栄養会誌. 13. 76-83 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 大橋 正伸: "携帯型バルーン式インフュザ-によるリトドリン持続投与の検討" 日産婦誌. 45. 967-972 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 小原 範之: "妊産婦・褥婦のカルシウム代謝" 産婦進歩. 45. 783-784 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 柴田 晴弘: "合併症妊娠における分娩、産褥時の母児間ACTH,Cortisol,Corticosteroid-binding Globulin値の動態" 日新生児会誌. 29. 231-241 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 竹内 節子: "経母体栄養剤負荷時の母児間における脂質、糖、アミノ酸代謝動態" 日新生児会誌. 29. 329-338 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 森川 肇: "脂質代謝と内皮細胞障害" 妊中誌. 1. 29-33 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 後藤 公亮: "妊娠高血圧症における細胞内Mg^<2+>の動態" 妊中誌. 1. 65-66 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 山崎 峰夫: "妊娠固体の末梢抵抗血管の収縮ならびに内膜依存症弛緩反応に関する基礎的検討" 妊中誌. 1. 123-124 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 寺本 憲司: "妊娠中毒症病態における血中血小板活性化因子(PAF)分泌動態の意義" 産婦進歩. 46. 173-186 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 太田 岳人: "妊娠高血圧症妊婦におけるエンドセリン-I(ET-I)分泌動態-血中濃度の測定ならびにヒト臍帯血管内皮細胞のEF-I合成に及ぼす性ステロイドホルモンの意義-" 産婦進歩. 46. 187-195 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 山崎 峰夫: "妊産褥婦管理の問題点-異常の早期発見と対処のしかた、妊娠初期-21GC15:産婦進歩" 46. 229-236 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 中後 聡: "栄養代謝状態とラット母獣血中Insulin-like growth Factor-I(IGF-I)の動態に関する基礎的検討" 日内分泌誌. 70. 85-94 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 妹尾 純子: "正常および異常妊娠における母体血中Insulin-like Growth Factor-I(IGF-I)の動態解析とその臨床的意義" 日内分泌誌. 70. 597-608 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 山崎 峰夫: "末梢血管攣縮のメカニズムからみた妊娠中毒症の病態解析" 妊中誌. 2. 95-98 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] スルタナ・ベグム: "尿中-酸化窒素代謝物の妊娠に伴う変動" 妊中誌. 2. 111-112 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 田中 あゆみ: "妊娠中毒症とリポ蛋白組成" 妊中誌. 2. 153-154 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 後藤 公亮: "妊娠高血圧症におけるMg動態" 妊中誌. 2. 155-156 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Mochizuki: "Recent Advances in Perinatology28HD01:1993" Ed. H.M.Sulchan Sofoewan and B.Winardi Soeprono. Center for Perinatology of Gadjamadah Univ., Yogyakarta., 8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M. Deguchi: "Recent Advances in Perinatology28HD02:1993" Ed. H.M.Sulchan Sofewan and B.Winardi Soeprono. Center for Perinatology of Gadjamadah Univ., Yogyakarta., 8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 望月 眞人: "今日の診断指針 第三版" 亀山正邦、亀田治男、高久史麿、阿部令彦、医学書院, 5 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 山崎 峰夫: "妊娠中毒症-最近の動向-" 関場晋監修、江口勝人編、金原出版, 10 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 森川 肇: "妊娠中毒症とカルシウム代謝" 関場晋監修、江口勝人編、金原出版, 10 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 望月 眞人: "臨床病理学 第5巻" 小酒井望監修、大場康寛編、医歯薬出版, 13 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 望月 眞人: "産婦人科学書 2 周産期医学" 杉山陽一、水野正彦、望月眞人、中野仁雄編、金原出版, 11 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 森川 肇: "産婦人科学書 2 周産期医学" 杉山陽一、水野正彦、望月眞人、中野仁雄編、金原出版, 16 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 丸尾 猛: "産婦人科学書 2 周産期医学" 杉山陽一、水野正彦、望月眞人、中野仁雄編、金原出版, 8 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 望月 眞人: "最新内科学大系 77、関連領域疾患" 井村裕夫、尾形悦郎、高久史麿、垂井清一郎編, 13 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Takehito Ohta, Hajime Morikawa, Mineo Yamasaki and Matsuto Mochizuki: "Serum level of Endothelin-1 and its regulatory mechanism in pregnancy-induced hypertension" Adv.Obstet Gynecol.46. 187-195 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kenji Teramoto, Hajime Morikawa, Mineo Yamasaki and Matsuto Mochizuki: "Studies on the role or platlet activating factor in the pathophysiological of preeclampsia" Adv.Obstet Gynecol.46. 173-186 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hajime Morikawa, Mineo Yamasaki, Ayumi Tanaka, Masaki Takashima, Kousuke Goto, Masatoshi Kanda and Matsuto Mochizuki: "The abnomalities of fat metabolism and vascular endothelial cell damages in the women with pregnancy induced hypertension" Journal of Japan Society for the Study of Toxemia of Pregnancy. 1. 29-33 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Mineo Yamasaki, Matsuto Mochizuki, Jason G.Umans and Marshall D.Lindheimer: "Invitro studies on contractile responses and endothelium-dependent relaxation of resistant vessels of pregnant rats" Journal of Japan Society for the Study of Toxemia of Pregnancy. 1. 123-124 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Masaki Takashima, Mineo Yamasaki, Masanobu Ohashi, Hajime Morikawa and Matsuto MOCHIZUKI: "A trial of low-dose aspirin therapy in high-risk pregnancy" Acta Obst Gynaec Jpn.44. 845-852 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kousuke Goto, Hajime Morikawa, Mineo Yamasaki, Masaki Takashima, Ayumi Tanaka, Masatoshi Kanda and Matsuto Mochizuki: "Magnesium metabolism in pregancy-induced hypertension (PIH)" Journal of Japan Society for the Study of Toxemia of Pregnancy. 1. 65-66 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sri Kadarsih Soejono, H.Morikawa and M.Mochizuki: "Maternal thyroid function and fetal growth in the endemic goiter area in lndonesia" Adv.Obstet Gynecol.46. 579-587 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sri kadarsih Soejono: "Maternal thyroid function and fetal growth in the endemic goirer area in Indonesia." Adv.Obstet Gynicol.46. 597-587 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 寺本憲司: "妊娠中毒症病態における血中血小板活性化因子(PAF)分泌動態の意義" 産婦進歩. 46. 173-186 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 太田岳人: "妊娠高血圧症妊婦におけるエンドセリン-1(ET-1)分泌動態の-血中濃度の測定ならびにヒト臍帯血管内皮細胞のET-1合成に及ぼす小モステロイドホルモンの意義-" 産婦進歩. 46. 187-195 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 山崎峰夫: "妊産褥婦管理の問題点-異常の早期発見と対処のしたか、妊娠初期-" 産婦進歩. 46. 229-236 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 望月眞人: "妊娠中毒症とその治療" 産婦治療. 68. 498-502 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 森川肇: "成長因子とIUGR" 臨産婦. 48. 262-264 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 中後聡: "栄養代謝状態とラット母獣血中Insulin-like growth Factor-1(IGF-1)の動態に関する基礎的検討" 日内分泌誌. 70. 85-94 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 妹尾純子: "正常および異常妊娠における母体血中Insulin-like Growth Factor-1(IGF-1)の動態解析とその臨床的意義" 日内分泌誌. 70. 597-608 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 望月眞人: "妊娠時脂質代謝の特異性" ペリネイタルケア. 13. 663-670 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 小原範之: "妊娠・産褥期のカルシウム代謝調節ホルモンPTHとPTHrP" The Bone. 8. 53-60 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 山崎峰夫: "末梢血管攣縮のメカニズムからみた妊娠中毒症の病態解析" 妊中誌. 2. 95-98 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] スルタナ・ベグム: "尿中一酸化窒素代謝物の妊娠に伴う変動" 妊中誌. 2. 111-112 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 田中あゆみ: "妊娠中毒症とリポ蛋白組成" 妊中誌. 2. 153-154 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 後藤公亮: "妊娠高血圧症におけるMg動態" 妊中誌. 2. 155-156 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 望月眞人: "産婦人科学書2 周産期医学" 杉山陽一.水野正彦.望月眞人.中野仁雄編.金原出版, 11 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 森川肇: "産婦人科学書2 周産期医学" 杉山陽一.水野正彦.望月眞人.中野仁雄編.金原出版, 16 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 丸尾 猛: "産婦人科学書2 周産期医学" 杉山陽一.水野正彦.望月眞人.中野仁雄編.金原出版, 8 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 望月眞人: "最新内科学大系77.関連領域疾患" 井村裕夫.尾形悦郎,高久史麿.垂井清一郎 編, 13 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 寺本憲司: "妊娠中毒症病態における血中血小板活性化因子(PAF)分泌動態の意義" 産婦人科の進歩. 46. 173-186 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 太田岳人: "妊娠高血圧症妊婦におけるエンドセリン-1(ET-1)分泌動態" 産婦人科の進歩. 46. 187-195 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 森川 肇: "胎盤を中心とした内分泌と糖脂質代謝" 産婦人科の世界. 45. 291-300 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 森川 肇: "高脂血症の治療" 産婦人科の実際. 42. 869-875 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 山崎峰夫: "妊娠中毒症の管理(Ca代謝からみた治療)" 腎と透析. 35. 747-751 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 望月 眞人: "妊婦とカルシウム療法" 産婦人科治療. 65. 431-436 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 望月 眞人: "カルシウム代謝" 日本臨床栄養学会雑誌. 13. 76-83 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 望月 眞人: "妊娠中毒症を防ぐ" NHKきょうの健康. 8. 32-35 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 森川 肇: "妊娠中毒症ー最近の動向ー 妊娠中毒症とカルシウム代謝" 金原出版, 10 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 山崎 峰夫: "妊娠中毒症ー最近の動向ー 妊娠中毒症の発症予知" 金原出版, 10 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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