| Project/Area Number |
04454435
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | SAITAMA MEDICAL SCHOOL |
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Principal Investigator |
SAKATA Eiji SAITAMA MEDICAL SCHOOL.NUROOTOLOGY.MEDICAL PROFESSOR, 医学部, 教授 (40118633)
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| Co-Investigator(Kenkyū-buntansha) |
MURATA Yasuhiro SAITAMA MEDICAL SCHOOL.NEUROOTOLOGY.MEDICAL DOCTOR, 医学部, 助手 (90229998)
HIRATSUKA Hitoshi SAITAMA MEDICAL SCHOOL.NEUROOTOLOGY.MEDICAL DOCTOR, 医学部, 助手 (80218792)
TERAMOTO Kazuhiro SAITAMA MEDICAL SCHOOL.NEUROOTOLOGY.MEDICAL DOCTOR, 医学部, 助手 (70197812)
ITO Yasuro SAITAMA MEDICAL SCHOOL.NEUROOTOLOGY.MEDICAL DOCTOR, 医学部, 助手 (50213096)
ITO Akinori SAITAMA MEDICAL SCHOOL.NEUROOTOLOGY.MEDICAL DOCTOR, 医学部, 講師 (20203127)
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1993: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1992: ¥4,300,000 (Direct Cost: ¥4,300,000)
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| Keywords | INNER EAR DISEASE / VERTIGO / TINNITUS / INNER EAR ANESTHESIA / VESTIBULAR COMPENSATION / DEXAMETHASONE INTRATYMPANIC INJECTION / OKAN / 内耳疾患の治療 / 鼓室内薬剤注入法 / 治療方法 |
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| Research Abstract |
1) Pitch match and loudness balance tests were used for detailed measurements of tinnitus which accompanied various inner ear disease. A pure-tone audiometer was used for the measurements. Inner ear anesthesia using Iidocaine and an intratympanic infusion of dexamethasone were used to treat various types of tinnitus. Inner ear anesthesia was highly effective in treating tinnitus occurring with sudden deafness and inner ear vertigo, but not for tinnitus accompanying head trauma and streptomycin toxicity. Intratympanic dexamethasone was highly effective in treating tinnitus accompanying chronic otitis media, syphilitic labyrinthitis and Meniere's disease but not against tinnitus due to head trauma.
2) Treatment of inner ear vertigo such as Meniere's disease were also examined. The effectiveness of inner ear anesthesia ear anesthesia for Meniere's disease according to the AAO-HNS criteria was complete suppression in 56%, marked effectiveness in 25%, effectiveness in 5%, ineffectiveness in
… More
4% and worse in 10%. The effectiveness of intratympanic dexamethasone was complete suppression in 57%, marked effectiveness in 23%, effectiveness in 8%, ineffectiveness in 10% and worse in 2%. These results is a useful treatment for inner ear disturbances such as vertigo and tinnitus.
3) Inner ear anesthesia was performed in 10 patients with unilateral peripheral vestibular disturbance due mainly Meniere's disease, and OKAN reactions were examined before and after inner ear anesthesia. Bilateral OKAN-I was suppressed after unilateral anesthesia of inner ear, followed by early appearance of bilateral OKAN-C.According to these results, the vestibular compensation from the vestibulo-cerebellum appears to act on the night and left velocity storage integrators symmetrically. The human OKAN accurately reflected vestibular compensation mediated by a velocity storage mechanism. Our results comfirm that the OKAN reaction mediated by a velocity storage mechanism reflects pathological changes in the inner ear, and suggest that electrophysiologic examinations of ocular movements such as OKAN are useful in investigating the pathology of inner ear disease. Less
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