| Project/Area Number |
04454448
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Kurume University |
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Principal Investigator |
MOCHIZUKI Manabu Kurume University School of Medicine, Professor, 医学部, 教授 (10010464)
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| Co-Investigator(Kenkyū-buntansha) |
ETO Koutaro Kurume University School of Medicine, Lecturer, 医学部, 助手 (70203635)
IWAKI Yoichi Kurume University School of Medicine, Assistant Professor, 医学部, 講師 (70203354)
YOSHIMURA Koichi Kurume University School of Medicine, Lecturer, 医学部, 助手 (30240352)
MIYAHARA Akihiro Kurume University School of Medicine, Lecturer, 医学部, 助手 (40209929)
NAGASAKI Hiroshi Kurume University School of Medicine, Assistant Professor, 医学部, 講師 (90172519)
白尾 真 久留米大学, 医学部, 助手 (20226319)
池田 英子 久留米大学, 医学部, 助手 (70222875)
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1993: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1992: ¥4,500,000 (Direct Cost: ¥4,500,000)
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| Keywords | HTLV-I / Uveitis / Vitreous opacities / Seroepidemiology / Polymerase chain reaction |
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| Research Abstract |
This study was aimed at determining the association of human T lymphotropic virus type 1 (HTLV-I) infection with certain type of uveitis that was classified as idiopathic on the basis of conventional diagnostic criteria. The seroprevalence of HTLV-I in idiopathic uveitis was significantly higher than that in two control groups, i. e. uveitis with defined etiology and non-uveitic ocular diseases. The odds ratio of idiopathic uveitis for HTLV-I infection was estimated to be 11.0 at younger aged group (20-49 years old), while being 2.0 at older aged group (50<) in an HTLV-I endemic area. A similar observation was recorded even in an HTLV-I less endemic area. Clinical features of the patients were characterized by intermediate uveitis consisting of moderate vitreous opacities, mild iritis and retinal vasculitis. Proviral DNA of HTLV-I was detected from inflammatory cells of the anterior chamber in all tested patients by polymerase chain reaction, suggesting the presence of HTLV-I infected cells in uveitic eyes.
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