• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Changes of cytokines and their gene expression in the process of carcinogenesis of oral precancerous lesions

Research Project

Project/Area Number 04454511
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 外科・放射線系歯学
Research InstitutionShowa University

Principal Investigator

NAGUMO Masao  Showa University, School of Dentistry, Professor, 歯学部, 教授 (70013993)

Co-Investigator(Kenkyū-buntansha) YAGAMI Kimitoshi  Showa University, School of Dentistry, Lecturer, 歯学部, 助手 (00210211)
IWASE Masayasu  Showa University, School of Dentistry, Assistant Professor, 歯学部, 講師 (50193743)
大島 修  昭和大学, 歯学部, 講師 (50167300)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥6,200,000 (Direct Cost: ¥6,200,000)
Fiscal Year 1993: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1992: ¥5,000,000 (Direct Cost: ¥5,000,000)
Keywordsprecancerous lesions / carcinogenesis / cytokines / gene expression / Langerhans cell / cell proliferation / c-myc / ウンゲルハンス細胞 / HLA-DR抗原 / TGF-alpha / IFN-gamma / 癌遺伝子 / ras / myc
Research Abstract

We investigated localization of cytokines and the expression of their genes in the specimens that were obtained from cancer patients whose cancer resions were developed from precancerous lesions or status, such as leukoplakia and papiloma. Changes of the numbers of Langerhans cells (LC) and HLA-DR antigen positive LC were also estimated before and after carcinogenesis. Further, the effect of cytokines (TNF-alpha, TGF-beta, IFN-gamma) or their combinations on cell proliferation of a oral cancer cell line (NA) was tested and the relationship between cell proliferation and the expression of protooncogenes (c-myc, ras) was estimated.
The results obtained were as follows :
1.The localization of TGF-alpha was increased with development to cancer, whereas TGF-beta was decreased with carcinogenesis. The increase of TGF-alpha was well correlated with that of PCNA which is now thought to be good marker of cell proliferation.
2.The Expression of TGF-alpha mRNA was increased with carcinogenesis.
3.The numbers of LC and HLA-DR antigen positive LC were increased with carcinogenesis.
4.The combination of TNF-alpha and TGF-beta or TNF-alpha and IFN-gamma inhibited cell proliferation of NA cells aditively or synergistically. The inhibition of cell proliferaton seemed to be brought about by the downregulation of c-myc mRNA expression.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Masato Hori et al.: "Downregulation of c-myc expression by tumor necrosis factor-α in combination with transforming growth factor.β or interferon-γ with concomitant inhibition of proliferation" Journal of Interferon Research. 14. 47-53 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shingo Yamaguchi et al: "Role of intracellular SoP in protecting human leukemic and cancer cells against superoxide and radiation" Free Radical Biology and Medicine. 14(in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 中村雅子 他: "前癌病変より悪性化を来たした9症例" 日本口腔外科学会雑誌. (投稿中). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 中村雅子 他: "口腔白板症の免疫組織化学的検討-主として異形成のみられる症例について" 第3回粘膜疾患研究会. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 堀雅人 他: "TNF-α単独およびTGF-β,IFN-γによるヒト癌細胞の遺伝子発現の調節" 第13回昭和歯学会例会. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 中村雅子 他: "口腔白板症より癌化した症例の免疫組織化学的検討" 第48回日本口腔科学会総会. (予定). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hori M.et al.: "Downregulation of c-myc expression by tumor necrosis factor-alpha in combination with transforming growth factor-beta of interferon-gamma with concomitant inhibition of proliferation in human cell lines." J.of Interferon Res.14. 47-53 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yamaguchi S.at al: "Role of intracellular SOD in protecting human leukemic and cancer cells against superoxide and radiation." Free Radical.Biol.and Med. 14 : (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nakamura M.at al: "Malignant progression of oral precancerous lesions : Report of 9 cases." Jap.J.of Maxillofac. Surg.(in submission).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nakamura M.et al: "Immunohistchemical study on oral Ieukoplakia.-Cases with epithelial dysplasia." The 3rd Annual Meeting of Oral Mucosal Diseases. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hri M.et al: "Regulation of protooncogene expression in human cancer cells by TNF-alpha in combination with TGF-beta or IFN-gamma." The 13th Annual Meeting of Showa Univ.Dent.Soc.(1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nakamura M.et al: "Immunohistchemical study on oral squamous cell carcinoma developed from oral leukoplakia." The 48th Annual Meeting of Oral Stom.Soc.(1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nasato Hori et al.: "Downregulation of c-myc expression by tumornecrosis foctor-alpha in combination with TGF-betaor IFN-gamma with concomitant inhibition of p〓tiferation in human cell lines" Jaurnal of Interferon Research. 14. 47-53 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Shingo Yamaguchi et al.: "Role of intracellular SOD in Protecting human leukemic and cancer cells against superoxids and radiation." Free Radical Biclogy and Medicine. 14,(in press). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 中村,雅子 他: "口腔白板症の免疫組織化学的検討-主として異形成のみられる症例について" 第3回粘膜疾患研究会. (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 堀,雅人 他: "TNF-alpha単独およびTGF-beta,IFN-gammaによるヒト癌細胞の遺伝子発現の調節" 第13回昭和歯学会例会. (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 中村,雅子 他: "口腔白板症より癌化した症例の免疫組織化学的検討" 第48回日本口腔科学会総会. (発表予定). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 中村 雅子 他: "前癌病変より悪性化をきたした9症例" 第2回口腔粘膜疾患研究会. (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 堀 雅人 他: "ヒト口腔癌由来培養細胞(NAcell)に対するTNFおよびTNFとTGF-βあるいはIFN-γの併用の効果" 第37回日本口腔外科学会総会. (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 山口 真吾 他: "各種ヒト癌由来培養細胞のスーパーオキシド感受性のヒ" 第37回日本口腔外科学会総会. (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 山口 真吾 他: "各種ヒト培養細胞のSOD活性とスーパーオキシドによる傷害性について" 第47回日本口腔科学会総会. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 中村 雅子 他: "前癌病変よりの悪性化症例におけるランゲルハンス細胞およびそのHLA-DR抗原発現の変化" 第3回口腔粘膜疾患研究会. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 堀 雅人 他: "TNFおよびTGF-βによる口腔癌由来培養細胞のrasおよびmyc mRNA発現の抑制" 第52回日本癌学会総会. (1993)

    • Related Report
      1992 Annual Research Report

URL: 

Published: 1992-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi