| Project/Area Number |
04454519
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
小児・社会系歯学
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
NONAKA Kazuaki KYUSHU UNIV., FAC.DENT., DEP.PEDIATRI.DENT., ASSOCIATE PROF., 歯学部, 助教授 (90128067)
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥6,200,000 (Direct Cost: ¥6,200,000)
Fiscal Year 1993: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1992: ¥5,100,000 (Direct Cost: ¥5,100,000)
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| Keywords | Mouse / Dentofacial growth / Embryo transfer / Fostering / Prenatal and Postnatal maternal effects / Cephalometry / Computerized measurement system / Genetics and environment / Crariofacial Browth / Self nursing / Cross nursing / Prenatal and Postnatal HaternalEffects / Cephalo metry / Tooth / Image Scanning System / Post natal Meternal Effect / Cephalogram |
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| Research Abstract |
Mammalian growth is snfluenced by the genetic and environmental effects. The purpose of the present research is to investigate the prenatal and postnatal maternal effects on the dentofacial growth in mice. Firstly, the embryo transfer experiment with DDD, C3H, C57BL and DBA strains of mice showed that there was an inverse relation between the litter size and dentofacial size but a direct relation between the gestation period and one, that there was a significant strain effect on the dentofacial growth of mouse fetuses, and that a significant inter-strain defference in the adjusted dentofacial size of the mouse fetuses developed from the same DDD/Qdj strain of embryo transferred to the four strains of recipients. Secondly, the fostering experiment with the large strain of DDD mouse and the small strain of C57BL mouse showed that the strain effect of nursing dam affected a significantly the postnatal growth of the offspring and that body size of offspring nursed by DDD strain of dam was significantly bigger than that of offspring nursed by C57BL dam. Theses results indicated that the prenatal and postnatal maternal effects playd an important effect on dentofacial growth in mice.
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