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Research on High-altitude Adapted Animal Models

Research Project

Project/Area Number 04454577
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Laboratory animal science
Research InstitutionSHINSHU UNIVERSITY

Principal Investigator

SAKAI Akio  SHINSHU UNIV., SCH.OF MED., ASSOCIATE PROFESSOR, 医学部, 助教授 (70020758)

Co-Investigator(Kenkyū-buntansha) MATUMOTO Seiji  SHINSHU UNIV., SCH.OF MED., ASOCIATE PROFESSOR, 医学部, 助教授 (40173893)
SAITO Muneo  JIKKENDOUBUTU-CHUOU-KENKYUJYO CHAREMAN, 室長 (50167417)
TAKEOKA Michiko  SHINSHU UNIV., SCH OF MED., ASSISTANT, 医学部, 助手 (30197280)
YANAGIDAIRA Yasunori  SHINSHU UNIV., SCH OF MED., ASSISTANT PROFESSOR, 医学部, 講師 (10020760)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥6,200,000 (Direct Cost: ¥6,200,000)
Fiscal Year 1993: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1992: ¥4,300,000 (Direct Cost: ¥4,300,000)
KeywordsHYPOXIA / High - altitude / Pika / HPV / Isolated lung / Cold / スンクス / Pika / 肺高血圧 / 右心室肥大 / HPVC
Research Abstract

In this project, three studies were performed. First study was to investigate the comparison of susceptibility to high - altitude among three mammalian species. Adult male Sprague Dawley( SD,n=10 )rats, Suncs( n=5 )and Pika( n=6 )were used. The ratio of right to left ventricular weight ( RVW/LVW ), haematocrit ( Ht ) and smooth muscle in media of pulmonary arterioles in Pikas showed significantly low values compared with SD rats. But not differences were observed between SD rats and Suncs. Second, the comparison of susceptibility to high - altitude among rat strains were examined. In this study, six strains of rat i e LEW SSN( n=7 ), F344/N( n=7 ), WM/MS( N=3 ), WKAH/HOK( n=7 ), WF/N( n=3 )and SD( N=27 )were used. To investigate potential differences in lung vascular control among these six rat strains, we measured the pressure response to acute alveolar hypoxia(3%O_2 )or angiotensin 2 injection in isolated perfused lungs. As the result, F334/N showed smallest pressure response to acute alveolar hypoxia and WKAH/HOK showed biggest response to hypoxia. Third, to investigate the effects of cold - exposure on pulmonary pressure response to hypoxia, we studied pressure responses in perfused lungs from rat that had been exposed to a cold environment, and those kept at a normal temperature. The pressure responses of rat lungs to hypoxia just after removal from the cold were significantly lower than that control value, bat the responses began to increase within 12 hrs, and reached a maximum 3days after cessation of cold - exposure. The increase was time - dependent.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (34 results)

All Other

All Publications (34 results)

  • [Publications] Takeoka,M.et al: "Effects of high altitudes on finger cooling test in Japanese and Tibetans at Qinghai plateau." Int.J.Biometeorol.37. 27-31 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Koizumi,Y.et al: "Effects of continuous in infusion of nitroglycerin on pulmonary hemodynamics,lung lymph balance,and prostanoid products in the response to endotoxim" Lung. 171. 19-30 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yanagidaira,Y.et al: "The effects of prolonged exposure to cold on hypoxin pulmonary hypertension in rats" J.Wilderness Medicine. 4. 18-25 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Asano,K.et al: "Time-dependent enhanced pressor responses in rat lungs after chronic exposure to moderate altitude" Acta.Physiol.Scand.149. 323-329 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakai,A.et al: "Effects of exercise training at 1500m on arterial oxygen saturation and puls rate." Aviation,Space and Environ.Med.65. 41-44 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 院 宗海 他: "寒冷暴露による低酸素性肺血管収縮抑制現象の回復過程" 環境科学年報. 16. 1-5 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yangidaira,Y.et al: "Physiological study of longevity in heritana insenes cence accelerated mous(SAM)strain" The first international conference on senescence (in press), (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Koyama, S.et al: "Dibutyryl cyclic AMP attenuated lung responses induced by endotoxin in conscious sheep." Am.Rev.Respir.Dis.146. 32-38 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakai, A.et al: "Effects of cinepazide on hypoxic pulmonary hypertension in conscious sheep." Jpn.J.Appl.Physiol. 22(5). 363-370 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ueda, G.et al: "Microcirculation and high altitude edema." Int.J.Sports Med. 13. S52-S54 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kashimura, O.et al: "Thermogenesis induced by inhibition of shivering during cold exposure in exercise - trained rats." Aviation, Space, and Environmental Medicine. 63. 1082-1086 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakai, A.et al: "Hypoxic pulmonary hypertension in exercising rats is lessened by training or db-cAMP." Jpn, J, Appl Physiol. 23(1). 7-15 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakai, A.et al: "Relation between breathing pattern and SaO_2 at high altitude." High-altitude Medicine. 116-122 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Asano, K.et al: "Abnormal breathing pattern and oxygen deasturation during sleep at high altitude." Control of Breathing and Its Modeling Perspecitive.455-458 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takeoka, M.et al: "Effects of high altitudes on finger cooling test in Japanese and Tibetans at Qinghai plateau." Int.J.Biometeorol. 37. 27-31 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Koizumi, Y.et al: "Effects of continuous in infusion of nitroglycerin on pulmonary hemodynamics, lung lymph balance, and prostanoid products in the reponse to endotoxin in awake sheep." Lung. 171. 19-30 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yanagidaira, Y.et al: "The effects of prolonged exposure to cold on hypoxic pulmonary hypertension in rats running head : hypoxic pulmonary hypertension." Journal of wildeness Medicine.4. 18-25 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakai, A.et al: "Effects of exercise Training at 1,500m on Arterial Oxygen Saturation and Pulse Rate." Aviation, Space and Environ, Med. 41-44 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takeoka, M.et al: "Cardio pulmonary function of cyclists competing on an ascending mountain course - altitudes from 1,400m to 2,800." Int.J.Biometeorol. (in press) (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yanagidaira, Y.et al: "Physiological study of longevity in heritance in senes cence accelerated mouse( SAM )strains." Elesvier Science Publishers B.(in press) (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takeoka,M.et al.: "Effects of high altitudes on finget cooling test in Japanease and Tibetans at Qinghai Plateau." Int.J.Bionneteorol. 37. 27-31 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Koizumi,Y.et al.: "Effects of continuoces in infurion of nitroglycerin onpulmonary hemodynamics lung lymph balance,and prostand products in the responses toendotoxin" Lung. 171. 19-30 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yanagidaira,Y.et al.: "The effects of prolonged exposur to cold on hypoxin plmonary hypertension in rats" J.Wildeness Medicine. 4. 18-25 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Asano,K.et al.: "Time-dependent enhanced pressor ressponses in rat lungs after chronic exparure to moderate altitude" Acta.Physiol.Scond. 149. 323-329 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Sakai,A.et al.: "Effects of exercise training at 1500m on arterial oxygen saturation and puls rate." Aviation,Space and Environ-Med. 65. 41-44 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 阮 宗海他: "寒冷暴露による低酸素性肺血管収縮抑制現象の回復過程" 環境科学年報. 16. 1-5 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] S.Koyama: "Dibutyril cyclic AMP attenuates lung responses induced by endotoxin in conscious sheep" Am.Rev.Respir.Dis.146. 32-38 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] A.Sakai: "Effects of cinepazide on high-altitude pulmonary hypertension in concious sheep" Jpn.J.Appl.Physiol.22. 363-370 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] O.Kashimura: "Thermogenesis induced by inhibition of shivering during cold exposure in exercise-trained rats" Aviation,Space,and Environ.Med. 63. 1082-1086 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] A.Sakai: "Hypoxic pulmonary hypertension in exercising rats is lessened by training or db-CAMP" Jpn.J.Appl.Physiol.23. 7-15 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] G.Ueda: "Microcirculation and High-altitude edema" Int.J.Sports Med.13. S52-S54 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Koizumi: "Effects of continuous infusion of nitroglycerin on Pulmonary hemodynamics,lung lymph balance,and prostanoid prosducts in the response to endotoxin in awake sheep" Lung. 171. 19-30 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] A.Sakai: "Relation between breathing pattern and SaO_2 at high-altitude;High-altitude Medicine" G.Ueda,J.T.Reeves,M.Sekiguchi, 116-122 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Asano: "Acclimatization to high-altitude in lowlanders:assesment with EEG and exercise test in 1990 Qinhai plateu expedition;High-altitude Medicine" G.Ueda,J.T.Reeves,M.Sekiguchi, 259-262 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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