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核磁気共鳴装置による運動中の筋代謝の非観血的及び連続測定

Research Project

Project/Area Number 04454588
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 体育学
Research InstitutionOsaka University

Principal Investigator

YOSHIDA Takayoshi  Osaka University Faculty Health & Sport Sci., Associate Professor10DA01 : 10077692, 健康体育部, 助教授 (30097331)

Co-Investigator(Kenkyū-buntansha) WATARI Hiroshi  National Institute for Physiological Sciences, 生理学研究所, 教授 (10079692)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1993: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1992: ¥3,000,000 (Direct Cost: ¥3,000,000)
Keywords31P-NMR / Exercise / Creatine Phosphate / Inorganic Phosphate / Muscle pH / ^<31D>P-NMR / クレアチンりん酸 / 筋エネルギー代謝 / 長距離選手
Research Abstract

It has been well documented that ^<31>phosphorus-nuclear magnetic resonance spectroscopy (^<31>P-MRS) has been used as a non invasive measurement of changes in concentrations of adenosine 5ユ^<**> triphosphate (ATP), phosphocreatine (PCr) and inorganic phosphate (Pi), as well as the intramuscular pH both during and after exercise. Splitting of the Pi peak into two peaks has been observed during exercise and is attributed to two different pH distributions in exercising muscle (high pH and low pH). Previously, we reported that the two split Pi peaks showed different time courses at the onset of exercise and during recovery, the high-pH Pi increased promptly at the onset of exercise and disappeared rapidly after exercise, while the low pH Pi peak increased gardually with after a delay of about 60 sec at the onset of exercise and decreased over a longer period after exercise. To assess the physiological mechanism for Pi spiltting, we have studied the effect of exercise intensity, inspired oxygen concentration and/or cooling down on Pi peak splitting.
Pi peak splitting is observed dependent on the exercise intensity. In other words, the splitting was observed when the exercise energy metabolism can not solely derive from aerobic metabolism, above 1.0 value of Pi/PCr ratio, suggesting anaerobic glycolysis recruitment. Furthemore, low-pH Pi peak much more documented when hypoxic gas inhalation, suggesting anaerobic glycolysis documented. When active recovery was performed after the exercise, the low-pH value returned more quickly to the pre-exercise level than during passive recovery. The quick disappearance of the low-pH Pi peak can be explained by differences in removal of lactate by blood flow rate maintained during active recovery, and the subsequent acceleration of glycolysis in the FT fibers.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Yoshida,T.: "Muscle metabolism during repeated exercise studied by ^<31>P-MRS." Ann.Physiol.Anthrop.11. 241-250 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoshida,T.: "Non-invasive and continuous determination of energy metabolism during muscular contraction and recovery." Med.Sports Sci.37. 364-373 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoshida,T.: "^<31>P-MRS study of the time course of energy metabolism during exercise and recovery." Eur.J.Appl.Physiol.66. 494-499 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoshida,T.: "Metabolic consequences during interval exercise in long distance runners." Eur.J.Appl.Physiol.67. 261-265 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoshida,T.: "Changes in intramuscular pH during repeated exercise." Eur.J.Appl.Physiol.67. 274-278 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 吉田敬義: "運動時の^<31>P-MRSのPiピーク分裂と筋pHの動態について" 第8回生理・生体工学シンポジウム論文集. 275-280 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoshida, T.and Watari, H.: "Muscle metabolism during repeated exercise studied by 31P-MRS.Ann.Physiol.Anthrop." 11. 241-250 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoshida, T.and Watari, H.: "Non-invasive and continuous determination of energy metabolism during muscular contraction and recovery." Med.Sports Sci. 37. 364-373 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoshida, T.and Watari, H.: "31P-MRS study of the time course of energy metabolism during exercise and recovery." Eur.J.Appl.Physiol.66. 494-499 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoshida, T.and Watari, H.: "Metabolic consequences during interval exercise in long distance runners." Eur.J.Appl.Physiol.67. 261-265 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoshida, T.and Watari, H.: "Changes in intramuscular pH during repeated exercise." Eur.J.Appl.Physiol.67. 274-278 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoshida,T.: "Muscle metabolism during repeated exercise studied by ^<31>P-MRS." Ann.Physiol.Anthrop.11. 241-250 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yoshida,T.: "Non-invasive and continuous determination of energy metabolism during muscular contraction and recovery." Med.Sports Sci.,. 37. 364-373 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yoshida,T.: "^<31>P-MRS study of the time course of energy metabolism during exercise and recovery." Eur.J.Appl.Physiol.,. 66. 494-499 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yoshida,T.: "Metabolic consequences during interval exercise in long distance runners." Eur.J.Appl.Physiol.,. 67. 261-265 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yoshida,T.: "Changes in intramuscular pH during repeated exercise." Eur.J.Appl.Physiol.,. 67. 274-278 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 吉田敬義: "運動時の^<31>P-MRSのPiピーク分裂と筋pHの動態について." 第8回生理・生体工学シンポジウム論文集. 275-280 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yoshida, T. & Watari, H.: "Noninvasive and continuous determimation of energy metabolism during muscular contraction and recovery" Medicine and Sports Science. 37. 364-373 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yoshida, T. & Watari, H.: "Musclemetabolism during repeated exercise studied by 31P-MRS." The Annals of Physiological Anthroplogy. 11. 241-250 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yoshida, T. & Watari, H.: "Phosphorus metabolism during step function exercise in long distance runners and sprinters." The Physiologist. 35. 207 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yoshida, T. & Watari, H.: "Phosphorus metabolism during repeated exercise in long distance runners." Society of Magnetic Resonance in Medicine. 2711 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yoshida, T. & Watari, H.: "Muscle metabolites in long distance runners during interval exercise." Japanese Journal of Physiology. 42. S247 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 亘 弘,吉田 敬義,市川 修: "ヒト骨格筋の運動・回復時における無機燐・pH変化" 生化学. 64. 1019 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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