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Development of molecular manipulation technique based on host-guest interactions

Research Project

Project/Area Number 04555197
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 工業物理化学・複合材料
Research InstitutionGifu University

Principal Investigator

MIYATA Mikiji  Gifu Univ., Fac.of Eng., Assoc.Prof., 工学部, 助教授 (90029322)

Co-Investigator(Kenkyū-buntansha) TAHARA Hideyuki  Nippon Shokubai, Kawasaki Res.Lab.Section Manager, 川崎研究所, 室長
SADA Kazuki  Gifu Univ., Fac.of Eng., Assis.Prof., 工学部, 助手 (80225911)
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥10,500,000 (Direct Cost: ¥10,500,000)
Fiscal Year 1994: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1993: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1992: ¥7,100,000 (Direct Cost: ¥7,100,000)
KeywordsHost-Guest / Molecular Composites / Manipulation Technique / Molecular Arrangements / Facial Amphiphilicities / Bilayred Structures / Hydrogen Bonding / Molecular Graphics / X線構造解析 / 分子グラフィックス / ナノテクノロジー / 分子配列制御 / 面状両親媒構造 / ステロイド / 結晶工学 / ホストゲスト
Research Abstract

We aimed to develop a molecular manipulation technique on the basis of host-guest interactions. This research constitutes a pioneering work for an intransitive-verb-type technique, which utilizes an ability of organic molecules to assemble through weak chemical bonding automatically. The results are summarized as follows ;
1.We employed steroidal molecules, particularly bile acids and their derivatives, as organic hosts. These molecules have been well-known since last century, but their abilities to form inclusion crystals are not known except deoxycholic acid and apocholic acid. We found that most of the steroids form the inclusion compounds with a variety of organic substances. The inclusion behaviors varies from one case to another. This indicates that inclusion phenomena are general in organic substances, because isomers of the steroids amount to over one billion.
2.We determined over fifty crystal structures of the inclusion compounds. It was found that facially amphiphilic molecules associate through hydrogen bonding to give bilayred assemblies. Comparative studies of the assemblies clarified that the amphiphilic layrs stack together in various ways. This indicates that asymmetric middle-molecular-weight molecules cause some diversity.
3.We confirmed that the controlled combination among multiple hydrogen-bonding groups may serve as the most important step for the manipulation technique of organic molecules. Four or three discrete hydrogen bonding groups associate together in various ways. This diversity is responsible for variable inclusion phenomena which is dependent on the host structures.
4.We constructed a system suitable for studying on various aspects of the host-guest interactions by using personal computers. The system enabled us to construct and search a data base of the steroidal inclusion compounds.

Report

(4 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (51 results)

All Other

All Publications (51 results)

  • [Publications] 宮田幹二: "ホスト・ゲスト分子複合体の発展" 新素材. 3. 60-64 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 宮田幹二: "コール酸およびその誘導体による分子情報の表現" 日本化学会誌. 128-138 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K. Sada: "A Novel Molecular Channel with a Hydrogen Bond'Hook'; Inclusion Phenomena of Cholanamide and the Crystal Structure of a 1:1 Complex of Cholanamide and1, 4-Dioxane" Jorunal of Chemical Society, Chemical Communications. 753-755 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K. Sada: "Inclusion Crystals of Cholic Acid and Cholanamide with Alcohols:Imoprtance of Hydrogen Bond"Double Hooks"" Chemistry of Materials. 6. 1103-1105 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K. Sada: "Inclusion Phenomena of Glycine-conjugated Bile Acids and the Crystal Structure of 1: 1 Complexof Glycodeoxycholic Acid and Tetrahydrofuran" Jorunal of Chemical Society, Chemical Communications. 905-907 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K. Nakano: "Guest-participating Reversion of Molecular Arrangements of Asymmetric Bilayers in Cholic Acid Inclusion Crystals" Jorunal of Chemical Society, Chemical Communications. (in press). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 宮田幹二: "化学総説:超分子をめざす化学" 学会出版センター(印刷中), (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M. Miyata: "Comprehensive Supramolecular Chemistry, Vol.5, Solid State Supramolecular Chemistry: Crystal Engineering; Deoxycholic Acid and Related Hosts" Pergamon (Oxford, UK) (in press), (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Miyata: "Development of Host-guest Molecular Composites." New Marweials. 3 (6). 60-64 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Miyata: "Expression of Molecular Information of Organic Molecules through Flexible Bilayred Assemblies." Biophysics. 32. 169-173 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Miyata: "Expression of Molecular Information of Cholic Acid and Its Derivatives." Nippon Kagaku Kaishi. 128-138 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Miyata: "Guest-Dependent Conformations of Side Chains in Cholic Acid Inclusion Compounds." Supramol.Chem.2. 283-288 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Sada: "A Novel Molecular Channel with a Hydrogen-Bond 'Hook' ; Inclusion Phenomena of Cholanamide and the Crystal Structure of a 1 : 1 Complex of Cholanamide and 1,4-Dioxane." J.Chem.Soc.Chem.Commun.753-755 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Sada: "Inclusion Crystals of Cholic Acid and Cholanamide with Alcohols : Importance of Hydrogen Bond "Double Hooks"." Chem.Mater.6. 1103-1105 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Sada: "Inclusion Phenomena of Glycine-conjugated Bile Acids and the Crystal Structure of 1 : 1 Complex of Glycodeoxycholic Acid and Tetrahydrofuran." J.Chem.Soc.Chem.Commun.905-907 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Miyata: "Hydrogen-Bonding Networks in Bilayred Crystals Composed of Facially Amphiphilic Compounds." Mol.Cryst.Liq.Cryst.240. 183-186 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Nakano: "Inclusion Compounds of Cholic Acid with Various Hydrocarbons and the Crystal Structure of a 1 : 1 Compound of Cholic Acid with Benzene." Chem.Lett.137-140 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Sada: "Interpretation of Variable Inclusion Abilities of Cholic Acid and Its Derivatives on the Basis of the Crystal Structures of 5beta-Petromyzonol." Chem.Lett.727-730 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Sada: "Specific Inclusion of Water by N-Methyl-deoxycholanamide Revealed by the Crystal Structure of the Hemihydrate." Chem.Lett.2113-2116 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Miyata: "Development to Expression of Molecular Information From Inclusion Polymerization-New World of Sequential Carbon-chain Oligomers-" Polymer Applications. 43. 560-565 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Sada: "Channel-type Inclusion Crystal with Hydrogen Bond 'Hooks' of Deoxycholanamide." Supramol.Chem.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Nakano: "Guest-participating Reversion of Molecular Arrangements in Asymmetric Multibilayrs in Cholic Acid Inclusion Compounds." J.Chem.Soc.Chem.Commun.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Sada: "Novel Molecular Arrangement in Asymmetric Bilayred Crystals of the Inclusion Compounds of 3alpha, 12alpha, 24-Trihydroxy-5beta-cholane." Supramol.Chem.(to be submitted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Miyata: "Reversible Intercalation of Guest Molecules in Crystals of Cholic Acid, "Reactivity in Molecular Crystals", ed.by Y.Ohashi." Kodansha-VCH. 153-164 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Miyata: "Deoxycholic Acid and Related Compounds, "Comprehensive Supramolecular Chemistry", Vol.5, Solid State Supramolecular Chemistry : Crystal Engineering, ed.by J.-M.Lehn." Pergamon. (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Miyata: "Inclusion Polymerization, "Comprehensive Supramolecular Chemistry", Vol.10, Special Topics Related to Supramoleclar Chemistry, ed.by J.-M.Lehn." Pergamon. (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Miyata: "Hydrogen-Bonding Networks in Bilayered Crystals Composed of Facially Amphiphilic Compounds" Molecular Crystal Liquid Crystals. 240. 183-186 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Sada: "Inclusion Phenomena of Glycine-conjugated Bile Acids and the Crystal Structure of 1:1 Complex of Glycodeoxycholic Acid and Tetrahydrofuran" Jorunal of Chemical Society,Chemical Communications. 905-906 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Sada: "Interpretation of Variable Inclusion Abilities of Cholic Acid and Its Derivatives on the Basis of the Crystal Structures of 5b-Petromyzonol" Chemistry Letters. 727-730 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Sada: "Inclusion Crystals of Cholic Acid and Cholanamide with Alcohols:Imoprtance of Hydrogen Bond “Double Hooks"" Chemistry of Materials. 6. 1103-1105 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Nakano: "Guest-participating Reversion of Molecular Arrangements of Asymmetric Bilayers in Cholic Acid lnclusion Crystals" Jorunal of Chemical Society,Chemical Communications. in Press. (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Sada: "Channel-type Inclusion Crystalwith Hydrogen Bond 'Hooks' of Deoxycholanamide" Supramolecular Chemistry.

    • Related Report
      1994 Annual Research Report
  • [Publications] in Press. (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 宮田幹二: "化学総説:超分子をめざす化学" 学会出版センター(印刷中), (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 宮田幹二: "化学便覧応用化学編 第五版" 丸善(印刷中), (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 宮田幹二: "コール酸およびその誘導体による分子情報の表現" 日本化学会誌. 128-138 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] M.Miyata: "Guest-dependent conformations of side chains in cholic acid inclusion compounds" Supramolecular Chemistry. 2. 283-288 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Sada: "A Novel Molecular Channel with a Hydrogen Bond‘Hook',Inclusion Phenomena of Cholanamide and the Crystal Structure of a 1:1 Complex of Cholanamide and 1,4-Dioxane" Journal of Chemical Society,Chemical Communications. 753-755 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Nakano: "Inclusion Compounds of Cholic Acid with Various Hydrocarbons and the Crystal Structure of a 1:1 Complex of Cholic Acid and Benzene" Chemistry Letters. 137-140 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Sada: "Inclusion Phenomena of Glycine-Conjugated Bile Acids and the Crystal Structure of a 1:1 Complex of Glycodeoxycholic acid and Tetrahedrofuran" Journal of Chemical Society,Chemical Communications. (印刷中). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Sada: "Interpretation of Variable Inclusion Abilities of Cholic Acid and Its Derivatives on the Basis of the Crystal Structure of 5b-Petromyzonol" Chemistry Letters. (印刷中). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] M.Miyata(分担執筆): "Polymerization in Organaized Media" Gordon and Breadch Science Publishers, 454 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 宮田幹二(分担執筆): "分子性結晶の反応" リアライズ社, 342 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] M.Miyata: "Intercalation Phenomena and Polymorphism of Cholic Acid Crystals" Molecular Crystals and Liquid Crystals. 219. 71-74 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 宮田 幹二: "二重層状柔構造体による有機分子の情報表現" 生物物理. 32. 169-173 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] M.Miyata: "Guest-Dependent Conformations of Side Chains in Cholic Acid Inclusion Compounds" Supramolecular Chemistry. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Sada: "A Novel Molecular Channel with a Hydrogen-Bond¨Hook¨;Inclusion Phenomena of Cholanamide and the Crystal Structure of a 1:1 Complex of Cholanamide and 184-Dioxane" Journal of Chemical Society,Chemical Communication. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 宮田 幹二: "コール酸およびその誘導体による分子情報の表現" 日本化学会誌. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] M.Miyata: "Reversible Intercalation of Guest Molecules in Crystals of Cholic Acid" 発表予定.

    • Related Report
      1992 Annual Research Report
  • [Publications] M.Miyata(分担執筆): "Polymerization in Organized Media" Gordon and Breach Science Publishers, 454 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 宮田 幹二(分担執筆): "分子性結晶の反応" リアライズ社, 342 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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