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An Study of Development of Method for Evaluation of Brain Function Using MEEG.

Research Project

Project/Area Number 04557050
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionFaculty of Medicine, Tokyo Medical and Dental University

Principal Investigator

TORU Michio  Tokyo Medical and Dental University Department of Neuropsychiatry Professor and Chairman, 医学部, 教授 (20013972)

Co-Investigator(Kenkyū-buntansha) MATSUSHIMA Eisuke  Tokyo Medical and Dental University Department of Neuropsychiatry, 医学部, 助手 (50242186)
OKUBO Yoshiro  Tokyo Medical and Dental University Department of Neuropsychiatry Lecturer, 医学部, 講師 (20213663)
ATSUMI Yoshikata  National Institute of Special Education, 部長 (90143552)
MATSUURA Masato  Nihon University Department of Neuropsychiatry Assistant Professor, 医学部, 助教授 (60134673)
KOJIMA Takuya  Nihon University Department of Neuropsychiatry Professor and Chairman, 医学部, 教授 (40014203)
島薗 安雄  (財)神経研究所, 理事長 (10013806)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥13,900,000 (Direct Cost: ¥13,900,000)
Fiscal Year 1993: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1992: ¥12,100,000 (Direct Cost: ¥12,100,000)
KeywordsMEEG / EEG / Dipole-tracing / MRI / Eplepsy / ダイポール / 高次脳機能
Research Abstract

It was aimed to develop the way of the accurate estimation of three-dimensional dipole locations of MEEG and EEG on three-dimensional MRI.An algorithm was developed in which the estimated equivalent dipoles are interposed on the three-dimensional MRI by means of overlapping the head shape measured for a model for dipole tracing and that obtained from the reconstruction of MRI data. For the estimation of dipole locations of EEG.the shape of subject's scalp and the three-dimensional locations of the 21 electrodes used according to the 10-20 system have to be measured with a special device. The dipole tracing method on a one- or two- dipole model with a correction based on a realistic head model were adopted for the estimation od equivalent dipoles of EEG.The estimated equivalent dipoles are located on the three-dimensional MRI by means of overlapping the head shape and that obtained from the three-dimensional MRI.This algorithm is applicable in the estimation of equivalent dipoles of MEEG on precise brain anatomy.
An attempt was carried out to use the developed method to estimate ictal EEG associated with epigastric aura which was incidentally observed and recorded in the case of a woman with temporal lobe epilepsy probably due to a hemangioma in the left mesial temporal lobe. The center of the equivalent dipoles during the burst of slow waves was found to be located close to the hemangioma and the lSD of the dipoles was about 10mm. This result suggests that the developed method is valid and useful for the identification of brain function on precise brain anatomy.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] O.Terasaki,Y.Okubo,M.Toru,et al: "Aquantitatire study on the stationarity of,EEGs of schizophrenia by a locally stationary autoregressive model." Neurology,Psychiatry and Brain Research. 1. 181-185 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] M.Matsuura,Y.Okubo,M.Toru et al: "A cross-national EEG study of children with emotional and behavioral problems." Biological Psychiatry. 34. 59-65 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] A.Senzaki,M.Toru et al: "Quantitative magnetic resonance imaging in patients with temporal lobe epilepsy." Journal of Epilepsy. 6. 243-249 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Y.Okubo,M.Matsuura,M.Toru et al: "A follow-up study of healthy children with epileptiform EEG diseharges." Journal of Epilepsy. 6. 250-256 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Y.Okubo,M.Matsuura,M.Toru et al: "A study of Epileptiform EEG discharges in healthy children." Epilepsia. 35(印刷中). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Y.Okubo,M.Toru et al: "Dipole tracing of ictal EEG of Epigastric aura in a patient with temporal lobe epilepsy." The Japanses Journal of Psychiatry and Neurology. 48(印刷中). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 1)Nagase, Y., Okubo, Y., Matsuura, M., Kojima, T.and Toru, M.: "EEG coherence in unmedicated schizophrenic patients : topographical study of predominantly never medicated cases." Biological Psychiatry. vol 34. 1028-1034 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 2)Okubo, Y., Matsuura, M., Asai, J., Asai, K., Kato, M., Kojima, T.and Toru, M.: "A follow-up study of healthy children with epileptiform EEG discharges." J.Epilepsy. 6. 243-249 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 3)Terasaki, O., Okubo, Y., Matsuura, M., Toru, M., He, Y., Hou, Y.and Shen, Y.: "A quantitative study on the stationarity of EGGs of schizophrenics by a locally stationary autoregressive model." Neurol. Psychiat. Brain Res.1. 181-185 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 4)Senzaki, A., Okubo, Y., Abe, T., Matsuura, M., Moriiwa, M., Asai, K.and Toru, M.: "Quantitative magnetic resonance imaging in patients with temporal lobe epilepsy." J.Epilepsy. 6. 250-256 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 5)Matuura M, Toru M et al: "A Cross-national EEG study of children with emotional and behavioral problems" Biol. Psychiatry. 32. 1028-1034 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 6)Okubo Y, Toru M et al: "A study of epileptiform EEG discharges in helathy children." Epilepsia. in press. (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 7)Okubo Y, Toru M et al: "Dipole tracing of ictal EEG of epigastric aura in a patient with temporal lobe epilepsy." Japanese Journal of Psychiatry and Neurology. vol 48. (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] O.Terasaki,Y.Okubo,M.Toru et al: "A quantitative study on the stationarity of,EEGS of schizophrenia by a locally stationary autoregressive model" Neurology,Psychiatry and Brain Research. 1. 181-185 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] M.Matsuura,Y.Okubo,M.Toru et al: "A Cross-national EEG study of children with emotional and behaviaral problems" Biological Psychiatry. 34. 59-65 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] A.Senzaki,M.Toru et al: "Quantitative magnetic resonance imaging in patients with temporal lobe epilepsy" Journal of Epilepsy. 6. 243-249 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Y.Okubo,M.Matsuura,M.Toru et al: "A follow-up study of healthy children with epileptiform EEG disharges" Journal of Epilepsy. 6. 250-256 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Y.Okubo,M.Matsuura,M.Toru et al: "A study of Epileptiform EEG discharges in healthy children." Epilepsia. 35 (印刷中). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Y.Okubo,M.Toru et al: "Dipole tracing of ictal EEG of Epigastvic aura in a patient with temporal lobe epilepsy" The Japanese Journal of Psychiatry and Nearology. 48 (印刷中). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Y.Nagase,Y.Okubo,M.Matsuura,T.Kojima: "Topographical changes in alpha power in medicated and unmedicated schizophrenics during digit span test" Biological Psychiatry. 32. 870 879 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Y.Nagase,Y.Okubo,M.Matsuura,M.Toru: "EEG coherence in unmedicated schizophrecnic patients-Topographical study of predominantly never medicated cases" Biological Psychiatry. 32. 1028 1034 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] O.Terasaki,Y.Okubo,M.Matsuura,M.Toru: "A quantitative study on the stationarity of EEGs of schizophrenics by a locally stationary autoregressive model" Neurology,Psychiatry and Brain Research. (1993)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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