Novel Synthetic Surgical Adhesive Incorporated with Biomechanical Concept

Research Project

Project/Area Number	04557055
Research Category	Grant-in-Aid for Developmental Scientific Research (B)
Allocation Type	Single-year Grants
Research Field	General surgery
Research Institution	National Cardiovascular Center Resesarch Institute
Principal Investigator	MATSUDA Takehisa National Cardiovascular Center, Head, 生体工学部, 部長 (60142189)
Co-Investigator(Kenkyū-buntansha)	ITO Tetsuro 三洋化成(株), 中央研究所, 主任研究員 MIWA Hiromichi National Cardiovascular Center, Resident, 生体工学部, レジデント研究生 SUGAWARA Takashi National Cardiovascular Center, Researcher, 人工臓器部, 室員 (70235860) TAKAICHI Shigeko National Cardiovascular Center, Researcher, 病因部, 室員 (00093930) NAKAYAMA Yasuhide National Cardiovascular Center, Researcher, 生体工学部, 室員 (50250262)
Project Period (FY)	1992 – 1993
Project Status	Completed (Fiscal Year 1993)
Budget Amount *help	¥7,700,000 (Direct Cost: ¥7,700,000) Fiscal Year 1993: ¥2,200,000 (Direct Cost: ¥2,200,000) Fiscal Year 1992: ¥5,500,000 (Direct Cost: ¥5,500,000)
Keywords	Adhesive Glue / Biodegradation
Research Abstract	The purpose of this research project is to develop a biodegradable, synthetic tissue adhesive glue which is based on a urethane prepolymer incorporated with hydrolyzable ester groups is a molecule. Our previous study showed that urethane prepolymers specially designed as a surgical adhesive performed very well in vivo even in cases with massive bleeding. However, the major drawback was too slow biodegradation rate. In order to improve this problem, a new research project was initiated here. Revised molecular design was to incorporate hydrolyzable biodegradable functional groups in a molecule. To this end, a polyester type polyol was newly prepared and incorporated into a designed prepolymer. In vivo animal experiments using rats verified that new version of synthetic glue exhibited a much faster biodegradability but maintained its adhesivity and mechanical adaption in very hostile, pulsatile conditions.