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Gratt Safety Limits in LRLT : Donor and Recipient

Research Project

Project/Area Number 04557056
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionShinshu University

Principal Investigator

MAKUUCHI Masatoshi  Shinshu Univ.School of Medicine Professor, 医学部, 教授 (60114641)

Co-Investigator(Kenkyū-buntansha) MATSUNAMI Hidetoshi  Shinshu Univ.School of Medicine Research, 医学部, 助手 (40219457)
KAWASAKI Seiji  Shinshu Univ.School of Medicine Associate Professor, 医学部, 助教授 (80177667)
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥15,900,000 (Direct Cost: ¥15,900,000)
Fiscal Year 1994: ¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1993: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 1992: ¥4,800,000 (Direct Cost: ¥4,800,000)
Keywordsliver transplantation / living-related / liver resection / liver transplantation / recipient / donor / living donor / h-HGF
Research Abstract

Since the year of 1990 in Shinshu University and Kyoto University, the living-related liver transplantation (LRLT) has been used as a form of treatment for terminal liver disease patients. From this time, our attention has been turned to two problems that repeatedly appeared.
One of the problems is how much liver tissue can be taken as a graft without compromising the donor's health status. The other one is about the smaller graft that can support the recipient's metabolic demands.
In the last four years period we have performed 32 LRLT with a survival rate of about 90% (28 out of 32 patients) and have worked to solve these two problems. Here we briefly describe some of the conclusions.
From the total of 38 donors, 14 were submitted to left lateral segmentectomy ; 13 donors submitted to extended left lateral segmentectomy, and 11 donors submitted to a left lobectomy. All the donors had a postoperative period without major complications, being discharged in an average of one week, and retu … More rning to their social activities within two months. Based on these results it was made clear that the left lobectomy can be carried out for grafting in a normal subject without problems related to parenchyma reduction.
With regard to the smaller graft that can fit the demands of the recipient, we successfully transplanted to an adult patient a graft that was as small as 34% of the estimated standard liver volume (based on the body surface area). It represents a donor with good liver function, a graft harvested and transplanted based on safety metabolic limits (established for hepatectomies) , and also confirms the viability due to excellent preservation conditions related to the LRLT.
Analyzing the data obtained in these four years, we could conclude that the LRLT can be a safe procedure for healthy donors providing even the whole left lobe and for recipients receiving a graft that represents at least 34% of their standard liver volume, calculated from the body surface area. These limits, broader that the ones formerly in use, permit a new array of safe indications for LRLT. Less

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • Research Products

    (35 results)

All Other

All Publications (35 results)

  • [Publications] Masatoshi Makuuchi, et al: "Donor hepatectomy for living related partial liver transplantation." Surgery. 113. 395-402 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Seiji Kawasaki, et al: "The arterial ketone body ratio in living-related donors." Transplantation. 58. 1412-1414 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Seiji Kawasaki, et al: "Preoperative mesurement of segmental liver volume of donor for living related liver transplantation." Hepatology. 18. 1115-1120 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Seiji Kawasaki, et al: "Liver regeneration in recipients and donors after transplantaion" Lancet. 339. 580-581 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hidetoshi MATSUNAMI, et al: "Venous reconstruction using three recipient hepatic veins in living related liver transplantation." Transplantation. ( in press. ).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hidetoshi MATSUNAMI1, et al: "A case of fimilial amyloid polyneuropathy treated with partial liver transplantation usig a graft from a living related donor." Transplantation. ( in press. ).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 河原崎秀雄,佐々木睦男,幕内雅敏: "生体肝移植マニュアル" 中外医学社, 220 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N. J. Lygidakis, M. Makuuchi: "Pitfalls and complications in the Diagnosis and Management of Hepatobiliary and Pancreatic Diseases." Thieme Medical Publisher New York., 537 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Masatoshi Makuuchi, Seiji Kawasaki, Tohru Noguchi, et al.: "Donor hepatectomy for living related partial liver transplantation." Surgery. 113. 395-402 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Seiji Kawasaki, Masatoshi Makuuchi, Keiji Matsushita, et al.: "The arterial ketone body ratio in living-related donors." Transplantation. 58. 1412-1414 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Seiji Kawasaki, Masatoshi Makuuchi, Hidetoshi Matsunami, et al.: "Preoperative mesurement of segmental liver volume of donor for living related liver transplantation." Hepatology. 18. 1115-1120 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Seiji Kawasaki, Masatoshi Makuuchi, Sinpachi Isizone, et al.: "Liver regeneration in recipients and donors after transplantaion" Lancet. 339. 580-581 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hidetoshi Matsunami, Masatoshi Makuuchi, Seiji Kawasaki, et al.: "Venous reconstruction using three recipient hepatic veins in living related liver transplantation." Transplantation. 59 (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hidetoshi Matsunami, Masatoshi Makuuchi, Seiji Kawasaki, et al.: "A case of fimilial amyloid polyneuropathy treated with partial liver transplantation usig a graft from a living related donor." Transplantation. 59 (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hidetoshi Matsunami, Masatoshi Makuuchi, Seiji Kawasaki, et al.: "Living-related liver transplantation despite mojor arterial and" Transplantation. 56. 753-755 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hidetoshi Matsunami, Masatoshi Makuuchi, Seiji kawasaki, et al.: "Living-related Liver Transplantation in Fulminant Hepatic Failure." Lancet. 340. 1411-1412 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hidetoshi Matsunami, Masatoshi Makuuchi, Seiji Kawasaki, et al.: "Serial Changes of h-HGF and IL-6 in Living-Related Liver Transplantation with spesial reference to their relationship to intraoperative potal flow." Transplantation Proc. 24. 1971-1972 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y Hashikura, S Kawasaki, H Matsunami, et al.: "Effect of platelet-activating factor on cold-preserved liver grafts" British Journal of Surgery. 81. 1779-1782 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hashikura.Y., Makuuchi M., Kawasaki S.: "Successful living-related partial liver transplantation to an adult patient." Lancet. 343. 1233-1234 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hashikura Y,Kawasaki S et al.: "Triphenyltetrazolium chloride reduction assay for determination of the viability of the cold-preserved rat liver." Transplantation. 57. 1287-1289 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Koichi Urata, Seiji Kawasaki, Hidetoshi Matsunami, et al.: "Calculation of child and adult standard liver volume for liver transplantation" Hepatology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hide Kasai, Masatoshi Makuuchi, Ssiji Kawasaki, et al.: "Intraoperative color doppler ultorasonography for partial liver transplantation from the living donor in pediatric patients." Transplantation. 54. 173-175 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kawarasaki H,er al: "Partial liver transplantation from a living donor:experimental research and clinical experience." J Pediatr Surg. 29. 518-22 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Matsunami H,Makuuchi M,Kawasaki S,et al: "Venous reconstruction using three recipient hepatic veins in living related liver transplantation." Transpiantation. in Press.

    • Related Report
      1994 Annual Research Report
  • [Publications] Kawasaki S.et al: "Arterial ketone body ratio in liviug-related donors." Transplantation. 58. 1412-4 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kawasaki S.et al: "Extended lateral segmentectomy using intraoperative ultrasound to obtain a partial liver graft." Am J Surg. in Press.

    • Related Report
      1994 Annual Research Report
  • [Publications] Kawasaki S.et al: "Living-related liver transplantation with a wider application." Transplant Proc. in Press.

    • Related Report
      1994 Annual Research Report
  • [Publications] Matsunami H,Makuuchi M,Kawasaki S,et al: "A case of familial amyloid polyneuropathy treated with partial liver transplantation using a graft from a living related donor." Transplantation. in Press.

    • Related Report
      1994 Annual Research Report
  • [Publications] Masatoshi Makuuchi: "Donor hepatectomy for living related partial liver transplantation." Surgery. 113. 395-402 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Hidetoshi Matsunami: "Living-related liver transplantation despite mojor arterial and venous abnormalities." Transplantation. 56. 753-755 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Seiji Kawasaki: "Preoperative mesurement of segmental liver volume of donor for living related liver transplantation." Hepatology. 18. 1115-1120 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Seiji Kawasaki: "Living-related liver transplantation for pediatric patients." 日本小児外科学会雑誌. 29. 238-242 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Matsunami H: "New technique for measuring tacrolimus concenttration in blood." Am J Hosp Pharm. 51. 123 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Hashikura Y: "Intraoperative increment of platelet-activation factor in clinical liver transplantation" Clin Transplantation. 8. 27-29 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 幕内雅敏: "生体肝移植マニュアル" 中外医学社, 220 (1993)

    • Related Report
      1993 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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