| Project/Area Number |
04557058
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Institute of Development, Aging & Cancer, Tohoku University |
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Principal Investigator |
NITTA Shinichi Institute of Development, Aging & Cancer, Tohoku University, Department of Medical Engineering & Cardiology, Associate Professor, 加齢医学研究所, 助教授 (90101138)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUTOME Akira Nippon Zeon Co.Ltd.Investigator in chief, 主任研究員
HIYAMA Hirokuni Ebara Co.Ltd.Investigator in chief, 主任研究員
UCHIDA Naoki Department of Thoracic & Cardiovascular Surgery, Associate, 医学部, 助手 (70241635)
MATSUKI Hidetoshi Faculty of Engineering, Tohoku University, Associate Professor, 工学部, 助教授 (70134020)
HASHIMOTO Hiroyuki Institute of Fluid Science, Tohoku University, Professor, 流体科学研究所, 教授 (10006174)
檜山 浩国 (株)荏原総合研究所, 主任研究員
佐藤 尚 東北大学, 医学部, 講師 (20114499)
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| Project Period (FY) |
1992 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥17,400,000 (Direct Cost: ¥17,400,000)
Fiscal Year 1994: ¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1993: ¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 1992: ¥6,100,000 (Direct Cost: ¥6,100,000)
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| Keywords | Total artificial heart / Totally implantable system / percutaneous energy transmission / amorphous fiber / vibrating flow pump / high frequency pump generation / control of blood distribution / vascular impedance / Totally implantable / Total artificial heart / Percutaneous energy transmission / Fitting study / Vibrating flow pump / Hemolysis / Automatic control system / Pump efficiency / vibrating flow pump / oscillated blood flow / blood flow distribution / implantable artificial heart / total artificial heart / ventricular assist device / hemolysis / percutaneous energy transmission system |
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| Research Abstract |
Tohoku University artificial heart group proposed a new drive mechanism for a total artificial heart (TAH) which produces the vibrating flow in the high frequency area between 3 to 50 Hz. This vibrating flow pump (VFP) has been developing as a totally implantable TAH system because of following advantageous characteristics.
a.simple in drive mechanism and pump structure
b.high frequency generation (miniaturized TAH,possibility to have control method of blood distribution by changing the drive frequencies.
c.a single valve
d.one way flow stream
high efficient transcutaneous electric power transmission system
Hemolysis study
The values of plasma Hb after pumping of the VFP showed the almost same value as a commercially available centrifugal and roller pumps which was thought to be an acceptable value as clinical use in the ex vivo hemolysis tests.
Pump description and design improvement
The VFP consists of mainly an inlet and outlet cannulae, a vibrational tube with surrounded electric coils and an outflow valve. The improvement of the pump design was achieved from the information by the use of the flow visualization and hemolysis study.
Transcutaneous energy transmission system (TETS)
TETS is developed by the use of a primary and a secondary amorphous coils across the skin in the distance between 2,4 and 6mm showing 16,15, and 13% as the values of the total efficiencies of the drive system, respectively.
Animal experiments
Adult goats were used for pump fitting studies, acute hemodynamic, hemolysis evaluations and subchronic studies using VFPs as totally implantable TAH.In the details, see following papers.
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