| Project/Area Number |
04557070
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
麻酔学
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| Research Institution | KUMAMOTO UNIVERSITY |
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Principal Investigator |
TERASAKI Hidenori KUMAMOTO UNIVERSITY, ANESTHESIOLOGY, ASSOCIATE PROFESSOR, 医学部, 助教授 (30040562)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAGUCHI Hidehiro KUMAMOTO UNIVERSITY, ANESTHESIOLOGY, ASSISTANT, 医学部附属病院, 助手 (80253748)
YANO Toshiyuki KUMAMOTO UNIVERSITY, ANESTHESIOLOGY, ASSISTANT, 医学部, 助手 (50253729)
TSUNO Kyoji KUMAMOTO UNIVERSITY, ANESTHESIOLOGY, ASSISTANT, 医学部附属病院, 助手 (40163860)
USHIJIMA Kazuo KUMAMOTO UNIVERSITY, ANESTHESIOLOGY, INSTRUCTOR, 医学部附属病院, 講師 (60136752)
松田 史彦 熊本大学, 医学部附属病院, 助手 (50244140)
田尻 晃彦 熊本大学, 医学部, 助手 (50236527)
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 1993: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1992: ¥11,200,000 (Direct Cost: ¥11,200,000)
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| Keywords | RESUSCITATION / CARDIAC ARREST / EXTRACORPOREAL CIRCULATION / CEREBRAL RESUSCITATION / ANIMALS / ARTIFICIAL MEMBRANE LUNG / MANUALLY OPERATED PUMP / V-Aバイパス / 携帯用装置 / 溶血 / 人工肺 |
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| Research Abstract |
Recent success using emergency percutaneous cardiopulmonary bypass as a tool for resuscitation from cardiac arrest is very encouraging. However even a portable bypass machine is still large and heavy to be immediately transported to a patient. It needs also many man powers, special technique, and electricity. Advantages of cardiopulmonary bypass have remained limited. To facilitate this time consuming process, we developed a manually operated portable cardiopulmonary bypass system for emergency resuscitation. The device is composed of two self-inflating silicone ballon pumps with four one-way valves and a compact artificial lung. The priming volume of the circuit is about 450 ml, and the total weight of the primed device is less than 2 kg. By manual compression of the two silicone ballon pumps alternatively, the blood returns into the femoral artery through the artificial membrane lung, and the venous blood drained out simultaneously by self-inflating of one of the reservoir pumps. The device can provide the blood flow rate of 2.5-3.1L/min at maximum.
We applied this method to resuscitate an induced cardiac arrest by electric current in 9 dogs. During a period of cardiac arrest of 15 to 30 min, dogs were supported with the manually operated cardiopulmonary bypass. All of 9 dogs recovered completely without neurological sequelae. This innovation will improve the survival rate of cardiopulmonary cerebral resuscitation.
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