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METHODS FOR DEGRADING MUTAGENS

Research Project

Project/Area Number 04557109
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionOKAYAMA UNIVERSITY

Principal Investigator

HAYATSU Hikoya  OKAYAMA UNIVERSITY,FACULTY OF PHARMACEUTICAL SCIENCES,PROFESSOR, 薬学部, 教授 (10012593)

Co-Investigator(Kenkyū-buntansha) TSUIKI Hisanaga  DAIWABOU CREATE,RESEARCHER, テクノステーション, 研究員
SAITOU Yutaka  OKAYAMA UNIVERSITY,FACULTY OF PHARMACEUTICAL SCIENCES,PROFESSOR, 薬学部, 教授 (20025711)
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥17,600,000 (Direct Cost: ¥17,600,000)
Fiscal Year 1994: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 1993: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 1992: ¥8,900,000 (Direct Cost: ¥8,900,000)
KeywordsMUTAGEN / DEGRADATION / Fe-OCTACARBOXYPHTHALOCYANINE / RESIN BEARING METALLOPORPHYRIN / CHLOROPHYLLIN / HETEROCYCLIC AMINE / ポルフィリン担持樹脂 / 吸着 / グリーンレーヨン / Fe^<3+>-オクタカルボキシルフタロシアニン / Trp-p-2 / cigarette smoke condensate / 金属ポルフィリン / ペルオキシダーゼ / 酸化的分解
Research Abstract

1) Some of heterocyclic amines (Trp-P-1, Trp-P-2 and 2-amino-alpha-carboline) were degraded by the action of Fe-octacarboxyphthalocyanine-rayon(Fe-ocpc-rayon) in aqueous solutions. The presence of hydrogen peroxide in the solutions accelerated the degradation. Mutagens extracted from tabacco smoke also underwent the degradation by the Fe-ocpc-rayon.
2) IQ was converted to red colored dimer by the action of a resin bearing Mn- or Fe-tetrakis (sulfonyl) porphine ligand in the presence of hydrogen peroxide.
3) Hemin and chlorophyllin stimulated the degradation of benzo (a) pyrene-7,8-diol-9,10 epoxide, a potent carcinogenic metabolite of benzo(a)pyrene.

Report

(4 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] H. Hayatsu: "Cellulose bearing covalently linked copper phthalocyanine trisulfonate as an adsorbent selective for polycyclic compounds." J. Chromatography. 497. 37-56 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H. Hayatsu: "Dietary inhibitors of mutagenesis and carcinogenesis." Chemoprevention of Cancer. 387-418 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H. Hayatsu: "Porphyrins as potential inhibitors against exposure to carcinogens and mutagens." Mutation Res.290. 79-85 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H. Hayatsu: "Suppressing effect of Lactobacillus cassei administration on the urinary mutagenicity arising from ingestion of fried ground beef." Cancer Letters. 73. 173-179 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H. Hayatsu: "Dietary inhibitors against mutagenesis and carcinogenesis." Antimutagenesis and Anticarcinogenesis Mechanisms III. 387-418 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T. Negishi: "Inhibitory activity of chlorophyllin on the mutagenicity of carcinogens in Drosophila." Cancer Letters. 83. 157-164 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.HAYATSU: "Cellulose bearing covalently linked copper phthalocyanine trisulfonate as an adsorbent selective for polycyclic compounds." J.Chromatography. 497. 37-56 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.HAYATSU: "Dietary inhibitors of mutagenesis and carcinogenesis" Chemoprevention of Cancer. 387-418 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.HAYATSU: "Porphyrins as potential inhibitors against exposure to carcinogens and mutagens." Mutation Research. 290. 79-85 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.HAYATSU: "Suppressing effect of Lactobacillus cassei administration on the urinary mutagenicity arising from ingestion of fried ground beef." Cancer Letters. 73. 173-179 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.HAYATSU: "Dietary inhibitors against mutagenesis and carcinogenesis." Antimutagenesis and Anticarcinogenesis Mechanisms. III. 87-418 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.NEGISHI: "Inhibitory activity of chlorophyllin on the mutagenicity of carcinogens in Drosophila." Cancer Letters. 83. 157-164 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Negishi: "Inhibitory activity of chlorophyllin on the genotoxicity of carcinogens in Drosophila." Cancer Letters. 83. 157-164 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] H.Hayatsu: "Porphyrins as potetial inhibitors against exposure to carcinogens and mutagens." Mutation Res.290. 79-85 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] H.Hayatsu: "Suppressing effect of Lactobacillus casei administration on the urinary mutagenicity arising from ingestion of fried ground beef." Cancer Letters. 73. 173-179 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] H.Hayatsu: "Dietary inhibitors against mutagenesis and carcinogenesis." Antimutagenesis and Anticarcinogenesis Mechanisms III. 387-418 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] H.Hayatsu: "Cellulose bearing covalently linked copper phthalocyanine trisulfonate as an adsorbent selective for polycyclic compounds and its use in studies of environmental mutagens and carcinogens." J.Chromatography. 497. 37-56 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] S.Arimoto: "Binding of polycyclic planar mutagens to chlorophyllin resulting in the inhibition of the mutagenic activity." Mutation Res.

    • Related Report
      1992 Annual Research Report
  • [Publications] 明石 牧子: "Fe^+-オクタカルボキシフタロシアニンーセルロースによる変異原の分解について" 日本環境変異原学会第21回大会要旨集. 121- (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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