|Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1992: ¥1,600,000 (Direct Cost: ¥1,600,000)
Cyclodextrin (CD) is cyclic oligosaccharide consisting of glucopyranose units with a central cavity. While the outside of CD molecule is hydropilic, the cavity inside forms a hydropobic environment, and a variety of molecular species are held as guests in aqueous medium if they suitably fit in the space, making CD act as a host. Anotherfactor which governs the host-guest association is the guest hydrophobicity : more hydrophobic guest molecules form more stable inclusion complexes with CD.The present work concerns with (1) the solubility in water and the guest/host molar ratio of CD complexes with hydrophobic hydrocarbons, (2) a steric factor which governs the host-guest association, (3) a factor which governs the guest/host molar ratio in CD complexes prepared in the presence of two different guests, and (4) volatilization of nonelectrolytes from CD precipitates with volatile nonelectrolytes. Such informations are fundamental and important in applying CD to analytical chemistry. The part (1) was published in Bull. Chem.Soc.Jpn., 66, 1424-1429 (1993), under the title "Preparation of Cyclodextrin Precipitates with Volatile Hydrocarbons in Aqueous Media, and Determination of Hydrocarbon/Cyclodextrin Molar Ratios in the Precipitates", the part (2) was published in Nippon Kagaku Kaishi, 1501-1503 (1992), under the title "Association of Elemental Mercury with Cyclodextrins in Aqueous Medium", the part (3) was published in Bull.Chem.Soc.Jpn., 67, 578-581 (1994), under the title "Cyclodextrin Precipitates with Naphthalene-Biphenyl Mixed Guests in Aqueous Medium", and the part (4) is now preparing for publication.