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Survey of Angiostrongylus cantonensis in rats and establishment of serological method for diagnosis of angiostrongylosis

Research Project

Project/Area Number 04660332
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Applied veterinary science
Research InstitutionGifu University

Principal Investigator

KINJO Toshio  Fac.Agir.Professor, 農学部, 教授 (40045084)

Co-Investigator(Kenkyū-buntansha) MIAMOTO Nobuyuki  Fac.Agri.Assoc.Professor, 農学部, 助教授 (10144007)
杉山 誠  岐阜大学, 農学部, 助手 (80196774)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1992: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsAngiostrongylus cantonensis / Sero-diagnosis for angiostrongylosis / Prevalence of A.cantonensis / Rat lungworm
Research Abstract

1. Distribution of A.cantonensis among rats
A total of 427 rats (Rattus norvegicus) live-trapped in all but Atsuta among the 16 wards of Nagoya City, were surveyed for infection with A.cantonensis. The parasites were found in the pulmonary artery of rats trapped in Meito, Minami and Minato wards with incidence of 6.1% (5/82), 1.8% (1/55) and 5.0% (2/40), respectively. Totally 8 or 1.9% of 427 rats were parasitized.
A total of 781 slugs which may serve as an intermediate host were collected in the 3 wards where A.cantonensis was found, and were examined for third-stage larvae by oral inoculation to rats. No parasite was recovered from the inoculated rats.
2. Serological dianosis for angiostrongylosis
Antigens for serological examination were extracted by sonication or freezing and thawing from first- and second-stage larvae, and adult worms of A.cantonensis. Better results were obtained by ELISA using an atigen extracted from male adult worms. Thus, the prevalence of ELISA antibodies to A.cantonensis among rats in Nagoya City was surveyed using this antigen. Of 412 rat sera, 25 (6.1%) were seropositive.
Much more research is needed before the present serological procedure can become technically feasible for serological diagnosis of angiostrongylosis.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] 金城俊夫: "名古屋市のドブネズミにおける広東住血線虫の侵淫状況" 岐阜大学農学部研究報告. 58. 101-105 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 木村葉子: "名古屋市のドブネズミにおける広東住血線虫の抗体分布" 日本獣医師会雑誌. 47(発表予定). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] KINJO,Toshio: "A survey of Angiostrongylus cantonensis in rats in Nagoya City" Res.Bull.Fac.Agr.Gifu Univ.58. 101-105 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] KIMURA,Yoko: "Prevalence of antibodies to Angiostrongylus cantonensis in rats in Nagoya City" J.Jpn.Vet.Med.Assoc.47, in preparation. (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 金城俊夫: "名古屋市のドブネズミにおける広東住血線虫の侵淫状況" 岐阜大学農学部研究報告. 58. 101-105 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 木村葉子: "名古屋市のドブネズミにおける広東住血線虫の抗体分布" 日本獣医師会雑誌. 47 (発表予定). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kinjo,Toshio: "A survey of Angiostrongylus cantonensis in rats in Nagoya" Journal of Veterinary Medical Science. 55. (1993)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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