| Project/Area Number |
04660338
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied veterinary science
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| Research Institution | Rakuno-Gakuen University |
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Principal Investigator |
MORITA Chiharu Rakuno-Gakuen Univ., Dept.Vet.Med., Prof., 酪農学部, 教授 (50072369)
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| Co-Investigator(Kenkyū-buntansha) |
AMI Yasushi Natl.Inst.Hlth., Lab.Anim.Care, Res.Officer, 動物管理室, 研究官 (10202699)
UENO Hiroshi , 講師 (60137411)
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| Project Period (FY) |
1992 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1994: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1993: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1992: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | lymphocytic choriomeningitis virus / LCMV / wild house mouse / Mus musculus / subspecies / epidemiology / リンパ球性脈絡髄膜炎 / 水平伝播 / LCM / 東南アジア / Mus musculus castaneus |
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| Research Abstract |
Recently, we reported occurrence of antibodies and isolation of lymphocytic choriomeningitis virus (LCMV) in two international ports in Japan. Attempts to detect the antibody or the virus in any other place in Japan have not succeeded until now. We utilized genetic analysis of ribosomal DNA and mitochondrial DNA to detect subspecies of Mus.musculus in some areas including LCMV-positive ports in Japan. As the results, M.m.castaneus was assumed to be the carrier reservoir of the virus invading to Japan. There is no report detecting LCMV in the habitat area of M.m.castaneus. The survey of 6 countries including China revealed LCMV existed in M.m.castaneus. In addition, the antibodies against LCMV were revealed in the mice captured in the northern part of China where was the habitat of M.m.gansuensis. LCMV is thought to be maintained by vertical transmission from dams to their offsprings. We analyzed matrilineal linage of mice captured in Osaka Port. Horizontal transmission of the virus has an important role to maintain the virus in the population of the wild house mouse.
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