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Postnatal development and plasticity of sound localization centers

Research Project

Project/Area Number 04670036
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 神経解剖学
Research InstitutionKanazawa University

Principal Investigator

IKUDO Motoi  Kanazawa Univ., med. Schl., Professor, 医学部, 教授 (80108141)

Co-Investigator(Kenkyū-buntansha) OKAYAMA Shigeo  Kanazawa Univ., med. Schl., Assistant Professor, 医学部, 助手 (30019575)
KITAO Yasuko  Kanazawa Univ., med. Schl., Assistant Professor, 医学部, 助手 (00019613)
AMANO Osamu  Kanazawa Univ., med. Schl., Associate Professor, 医学部, 助教授 (70157874)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1992: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsNeurogenesis / Inferior colliculus / Superior olive / Rat / BrdU / Auditory pathways / Plasticity / Postnatal development / 聴覚中枢 / 神経発生学 / 脳傷害 / 神経線維連絡
Research Abstract

<Neurogenetical study>
By a combination of fluorescent retrograde axonal tracings and bromodeoxyuridine (BrdU) immunohistochemical techniques, time origins of projection neurons in the superior olive have been examined. In the lateral superior olive, neurons projecting to the contralateral inferior colliculus (IC) were generated on days E12 and E13, whereas neurons projcting to the ipsilateral IC were proliferated between days E14 and E16. In the medial superior olive (MSO), the IC projection neurons arose on E12, while, in the superior paraolivary nucleus, their peak production occurred on day E13. Also refer some publication (Kitao et al., brain Research, 1993) and oral presentations (International Workshopon Binaural Procssing in the Auditory Brainstem. Ottawa, Canada, 1993 ; Society for Neuroscience.Anaheim, California U.S.A., 1992).
<Normal development of auditory brainstem pathways and plasticity after unilateral ablation of the IC>
The results indicated that : 1) The projection froj the MSO to the IC was developed gradually in postnatal periodsas an exclusively uncrossed one without making axon-collaterals to the contralateral IC.2) When the IC was ablated unilaterally in certain postnatal period, many neurons died in the ipsilateral MSO as a result of axotomy. 3) An aberrant crossed projection to the contralateral IC occurs in some of the survived neurons in the MSO, although such aberrant fibers still maintained in adult were very few in number. 4) Growth of late-developing axons was a major factor in the plasticity of this system of projection.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] 尾小山重雄: "聴覚中枢の生後発達と可塑性." 金沢大学十全医学会雑誌. 103巻. 154-162 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kitao,Y.: "Neurogenetical segregation of the vestibulospinal neurons in the rat." Brain Research. 620巻. 149-154 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 工藤 基: "モグラの音感覚-聴覚脳の比較解剖学-." 日本音響学会雑誌. 49巻. 437-445 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 工藤 基: "聞く-機能からみた解剖生理-." ブレインナーシング. 9巻. 267-273 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Okoyama,S.: "Anatomical plasticity of the tectospinal tract after unilateral lesion of the superior colliculus in the neonatal rat." Experimental Brain Research. 85巻. 552-558 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kudo,M.: "Auditory brainstem in the mole(Mogera):nuclear configurations and the projections to the inferior colliculus." J.Comparative Neurology. 298巻. 400-412 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Okoyama, S.: "Postnatal Development of the auditory pathway and plasticity after unilateral ablation of the inferior colliculus in the rat" J.Juzen Medical Society. 103. 154-162 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kitao, Y.: "Neurogenetical segregation of the vestibulospinal neurons in the rat" Brain Research. 620. 149-154 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kudo, M.: "Auditory mechanisms in the mole : a review ofte comparative anatomy" J.Acoustical Society of Japan. 49 (6), (in Japanese). 437-445 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kudo, M.: "Hearing" Brain Nursing. 9 (3). 267-273 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kudo, M., Kitao, Y, Okoyama, S.and Moriizumi, T.: "Relationship between neuronal birthdates and the laterality of the projects in the rat lateral superior olive" Society for neuroscience Abstract. 18. 1038 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Okoyama, S.: "Anatomical plasticity of the tectospipnal tract after unilateral lesion of the superior colliculus in the neonatal rat" Experimental brain Research. 85. 552-558 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kudo, M., Nakamura, Y., Tokuno, H.and Kitao, Y.: "Auditory brainstem in the mole (Mogera) : nuclear configurations and the projections to the inferior colliculus" J.Comparative Neurology. 298. 400-412 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 尾小山重雄: "聴覚中枢の生後発達と可塑性." 金沢大学十全医学会雑誌. 103巻. 154-162 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kitao,Y.: "Neurogenetical segregation of the vestibulospinal neurons in the rat." Brain Research. 620巻. 149-154 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 工藤基: "モグラの音感覚-聴覚脳の比較解剖学-." 日本音響学会雑誌. 49巻. 437-445 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 工藤基: "聞く-機能からみた解剖生理-." ブレインナーシング. 9巻. 267-273 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Okoyama,S.: "Anatomical plasticity of the tectospinal tract after unilateral lesion of the superior colliculus in the neonatal rat." Experimental Brain Research. 85巻. 552-558 (1991)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kudo,M.: "Auditory brainstem in the mole(Mogera):nuclear configurations and the projections to the inferior colliculus." J.Comparative Neurology. 298巻. 400-412 (1990)

    • Related Report
      1993 Annual Research Report
  • [Publications] 工藤 基: "RELATIONSHIP BETWEEN NEURONAL BIRTHDATES AND THE LATERALITY OF THE PROJECTIONS IN THE RAT LATERAL SUPERIOR OLIVE." SOCIETY FOR NEUROSCIENCE ABSTRACTS.2. 1038-1038 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 北尾 康子: "NEUROGENETIC CLASSIFICATION OF PROJECTION NEURONS IN THE RAT VESTIBULAR NUCLEI." SOCIETY FOR NEUROSCIENCE ABSTRACTS.1. 508-508 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 工藤 基: "NEUROGENESIS OF THE AUDITORY BRAINSTEM IN THE RAT:A DOUBLE LABELING STUDY USING BRDU AND RETROGRADE FLUORESCENT TRACERS." Neuroscience Research. Sup.17. S249-S249 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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