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Various afferent inputs influencing the neuronal control of tracheal smooth muscle

Research Project

Project/Area Number 04670056
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General physiology
Research InstitutionToho University School of Medicine

Principal Investigator

ARITA Hideho  Toho University School of Medicine, Associate Professor, 医学部, 助教授 (20075576)

Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1992: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordscontrol of breathing / Medulla / Tracheal smooth muscle / Hiccup / Brain ischemia / C線維 / しゃくり
Research Abstract

The present study revealed various afferent inputs that influenced the activity of the extrathoracic trachea.
1 Excitation of the peripheral chemoreceptor by intravenous injection of cyanic acid produced a constriction of tracheal smooth muscle.
2 Activation of the central chemoreceptor by intra-vertebral arterial injection of CO_2 saturated saline caused tracheal constriction.
3 Intravertebral injection of N_2 saturated saline elicited a dilatation of the trache, indicating that ischemia of the brainstem causes tracheal dilation.
4 Stimulation of the pulmonary stretch receptor by lung inflation evoked a relaxation of tracheal tone. The lung inflation after vagotomy resulted in a paradoxical response, i.e., a constriction of the trachea.
5 Excitation of the irritant receptor of the upper airway produced the increased activity of the tracheal smooth muscle.
6 Electrical stimulation of the proximal end of the femoral nerves elicited the tracheal dilatation.
The present study also demonstrated that a hiccup-like response (a brief powerful inspiratory effort against glottic closure) were generated by electrical stimulation to a limited area within the medullary reticular formation of the cat. The effective sites were localized in the region lateral to the nucleus ambiguus. This finding indicates that there is a neuronal network coordinating the hiccup reflex within the lower brainstem.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Kondo,T.et.al.: "Centrally driven slow oscillating poteutial of extrathoracic frochea." Journal of Applied Physiology. 74. 1066-1072 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Oshima,T.et al.: "Hiccup-like response elicited by mehauical stimulation of dersal apphorynx of cat." Journal of Applied Physiology. in press. (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kondo, T., Kobayashi, I., Hirokawa, Y., Ohta, Y., Arita, H.: "Centrally driven slow oscillating potential of extrathoracic trachea." J.Applied Physiology. 74. 1066-1072 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Oshima, T., Sakamoto, M., Arita, H.: "Hiccup-like response elicited by mechanical stimulation of dorsal epipharynx of cat." J.Applied Physiology. (in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kondo,T.et al.: "Centrally driven slow oscillating poten tial of extrathoracic trachea" Journal of Applied Physiology. 74. 1066-1072 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Oshima,T.et al: "Hiccup-like response elicited by mechanical stimulation of dorsal epipharynx of cat." Journal of Applied Physiology. (in press). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Arita, H. et al.: "Serotonin Innervation Patterns Differ Among the Various Medullary Motoneuronal Groups Involved in Upper Airway Control" Experimental Brain Research.

    • Related Report
      1992 Annual Research Report
  • [Publications] 近藤 哲理 他: "気管および気管支の呼吸性調節の差異" 日本胸部疾患学会雑誌. 31. 259 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 広川 豊 他: "ネコ胸郭内気管平滑筋を支配する神経と延髄内サブスタンスP" 日本胸部疾患学会雑誌. 31. 258 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Arita, H. et al.: "Inhibition of serotonin‐ and adrenalin‐containing neurons in ventrolateral medulla." Neuroscience Research. Suppl17. S66 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 有田 秀穂: "Annual Review 呼吸器 1993 (分担) 呼吸器系のC線維終末" 中外医学社, P1-P7 (1993)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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