| Project/Area Number |
04670061
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | HIROSHIMA UNIVERSITY (1993-1994)
National Cardiovascular Center Research Institute (1992) |
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Principal Investigator |
NINOMIYA Ishio Hiroshima Univ.Sch.of Med.Prof., 医学部, 教授 (80033976)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRAI Mikiyasu Nat.Cardiovascular Ctr.Res.Inst.Asist.Prof., 室長 (70162758)
SHIMIZU Junichi Hiroshima Univ.Sch.of Med.Associ.Prof., 医学部, 助教授 (10126584)
進藤 哲明 国立循環器病センター研究所, 心臓生理部, 室員 (30235775)
秋山 剛 国立循環器病センター研究所, 心臓生理部, 室員 (70202554)
西浦 直亀 国立循環器病センター研究所, 心臓生理部, 室員 (70132933)
松川 寛二 国立循環器病センター研究所, 心臓生理部, 室長 (90165788)
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| Project Period (FY) |
1992 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1993: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1992: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | Cardiac Sympathetic nerve activity / Myocardial interstitial norepinephrine / Cardiac vagal nerve / Myocardial interstitial acetylcholine / Myocardial ishemia / Diameter of Puhuonary vessels. / 心臓交威神経 / α,β,γ-ブロッカー / 心表面血流量 / 心臓組織間アセチールコリン / Total Cardiac Sympathetic Nerve Activity / Synchronized CSNA / Nunber of Activated fivers' / Interstitial Norepinephrine Level / Ishemic region / Cardiac Reflex |
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| Research Abstract |
1).Analysis of cardiac sympathetic nerve activity (CSNA) : We found that 9,28,36,19 and 7% of CSNA were originated from Th1, Th2, Th3, Th4 and Th5 spinal segments, respectively.This suggests that the number of coronary vessels arranged in parallel are controlled by the same percentage of CSNA.
2).Measurement of my ocardial intestitial noradrenaline level in the bft ventricle : Myocardial interstitial noradrenaline level was increased in proportion to the stimulus frequency of sympathetic nerve.Regional ishemia was produced by coronary occlusion.Noradrenaline conceutrations increased by 70 times in the ishemic region but not in the nonishemic region.This increased noradrenaline was induced by increase in release from nerve terminal but not a decrease in reuptake of noradrenaline.
3).Measurement of interstitial acetylcholine in the left ventricle : Interstitial acethlcholine was increased in proportion to the stimulus freg.of vagal nerve.This released Ach.modulate the effect of noradrenaline on the ventricle.
4).Effects of sympathetic and vagal stimulation on the diameter of small wronary artery could not be detected by x ray apparatus, but their effects on the diameter and flow of small pulmonary vessels are measured.
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