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Brain stem mechanisms for generation of vertical fast eye movement

Research Project

Project/Area Number 04670062
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Neurophysiology and muscle physiology
Research InstitutionHokkaido University

Principal Investigator

FUKUSHIMA Kikurou  Hokkaido University School of Medicine Associate Professor, 医学部, 助教授 (70091486)

Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1992: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsVestibular nystagmus / Semicircular canal / Eye movement / Midbrain / Interstitial nucleus of Cajal / Saccade / Cat / 垂直眼球運動 / Burster driving neuron / muscimol
Research Abstract

It is well known that vestibular nystagmus evoked by head rotation occurs in the plane specific to that in which head rotation was applied in three-dimensional space. Although burster-driving neurons (BDN) habe been demonstrated for a quick phase of horizontal nystagmus (see Ref. 18), it is as yet unknown where the counterpart for vertical nystagmus is located. We searched for neurons in the rostral midbrain in alert cats that showed the characteristic discharge pattern required for BDNs(Kitama et al 1992) for vertical eye movement. Two groups of neurons were found in our study. Downward BDNs(n=48)received anterior canal excitation from the contralateral side with short latency ; upward BDNs(n=21) received posterior canal excitation. Mean lead time for the burst activity before fast eye movement was 30 msec for both saccades and vestibular fast phases for both groups of neurons. All of them had irregular resting discharge rates, and some showed eye positon sensitivity toward the direction opposite to their on-direction.
Downward BDNs were found in the interstitial nucleus of Cajal and its close vicinity ; whereas upward BDNs were found more laterally and caudally.
Bilateral muscimol infusion (0.3 mug for each side) into the downward BDN areas resulted in a selective loss of downward fast eye movement in addition to the failure of holding vertical eccentric eye position ; bilateral infusion into the upward BDN areas decreased number of upward fast eye movement significantly.
Horizontal eye movements were not impaired significantly by these imjections.
These results suggest specific involvement of vertical BDNs in generating vertical fast eye movement.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] Fukushima,K.: "Possible downward burster-driving neurons related to the anterior semicircular canal in the region of the interstitial nucleus of Cajal in alert cats." Neurosci.Res.12. 536-544 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fukushima,K.: "Ocular torsion produced by unilateral chemical inactivation of the inters titial nucleus of Cajal in chronically labyrinthectomized cats." Neurosci.Res.13. 301-305 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fukushima,K.: "The neuronal substrate of integration in the oculomotor system." Prog.Neurobiol.39. 609-639 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fukushima,K.: "The interstitial nucleus of Cajal is involved in generating downward fast eye movement in alert cats." Neurosci.Res.15. 299-303 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fukushima,K.: "Responses of floccular Purkinji cells to sinusoidal vertical rotation and effects of muscimol infusion into the flocculus in alert cats." Neurosci.Res.17. 297-305 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kaneko,C.R.S.: "Burst driver neurons in the mesencephalon of the trained rhesus monkey." Neurosci.Abst.19. 859 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fukushima,K.: "Vestibular and brain stem control of eye,head and body movement." Japan Scientific Societies Press,Karger, 466 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fukushima,K.: "Contemporary ocular motor and vestibular research:A tribute to David A Robinson" Georg Thieme Verlag Stuttgart(in press), (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fukushima, K., Fukushima, J., et al.: "Possible downward burster-driving neurons related to the anterior semicircular canal in the region of the interstitial nucleus of Cajal in alert cats." Neurosci. Res.12. 536-544 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fukushima, K., Ohashi, T., et al.: "Ocular torsion produced by unilateral chemical inactivation of the interstitial nucleus of Cajal in chronically labyrinthectomized cats." Neurosci. Res.13. 301-305 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fukushima, K., Kaneko, CRS, et al.: "The neuronal substrate of integration in the oculomotor system." Prog. Neurobiol.39. 609-639 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fukushima, K., Fukushima, J.: "The interstitial nucleus of Cajal is involved in generating downward fast eye movement in alert cats." Neurosci. Res.15. 299-303 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fukushima, K., Buharin EV., et al.: "Responses of floccular purkinje cells to sinusoidal vertical rotation and effects of muscimol infusion into the flocculus in alert cats." Neurosci. Res.17. 297-305 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kaneko, CRS, Fukushima, K.: "Burst driver neurons in the mesencephalon of the trained rhesus monkey." Neurosci. Abst.19. 859 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fukushima K., Fukushima K.: Vestibular and brain stem control of eye, head and body movement.Japan Scientific Societied Press, Karger, 466 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fukushima, K., Buharin, E.V., et. al.: Contemporary ocular motor and vestibular research : A tribute to David A Bobinson. Georg Thieme Verlag Stuttgart (in press),

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fukushima,K.: "Possible downward burster-driving neurons related to the anterior semicircular canal in the region of the interstitial nucleus of Cajal in alert cats." Neurosci.Res.12. 536-544 (1991)

    • Related Report
      1993 Annual Research Report
  • [Publications] Fukushima,K.: "Ocular torsion produced by unilateral chemical inactivation of the inters titial nucleus of Cajal in chronically labyrinthectomized cats." Neurosci.Res.13. 301-305 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Fukushima,K.: "The neuronal substrate of integration in the oculomotor system." Prog.Neurobiol.39. 609-639 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Fukushima,K.: "The interstitial nucleus of Cajal is involved in generating downward fast eye movement in alert cats." Neurosci.Res.15. 299-303 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Fukushima,K.: "Responses of floccular Purkinji cells to sinusoidal vertical rotation and effects of muscimol infusion into the flocculus in alert cats." Neurosci.Res.17. 297-305 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kaneko,C.R.S.: "Burst driver neurons in the mesencephalon of the trained rhesus monkey." Neurosci.Abst.19. 859 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Fukushima,K.: "Vestibular and brain stem control of eye,head and body movement." Japan Scientific Societies Press,Karger, 466 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Fukushima,K.: "Contemporary ocular motor and vestibular research:A tribute to David A Robinson" Georg Thieme Verlag Stuttgart(in press), (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Fukushima K.: "Ocular torsion produced by unilateral chemical inactivation of the interstitial nucleus of Cajal in chronically labyrinthectomized cats." Neurosci.Res.13. 301-305 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Fukushima K.: "The interstitial nucleus of Cajal is involved in generating downward fast eye movement in alert cats." Neurosci.Res.15. 299-303 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Fukushima K.: "Impairment of vertical eye movement produced by chemical deactivation of the interstitial nucleus of Cajal and activity of eye movement-related neurons in chronically labyrinthectomized cats." Acta.Otolaryngol.(Stockh). Suppl.

    • Related Report
      1992 Annual Research Report
  • [Publications] Fukushima K.: "The neuronal substrate of integration in the oculomotor system." Prog.Neurobiol.39. 609-639 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Fukushima K.: "Head-neck sensory motor system." Oxfor University Press,New York, 748 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Fukushima K.: "Vestibular and brain stem control of eye,head and body movements." Japan Scientific Societies Press,Karger,Tokyo, 466 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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