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Synaptic up-and down-regulation by changes in intracellular calcium concentrations

Research Project

Project/Area Number 04670072
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 科学技術史(含科学社会学・科学技術基礎理論)
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

KATO Nobuo  Kyoto Univ.Fac.Med., Instructor, 医学部, 助手 (10152729)

Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1993: ¥400,000 (Direct Cost: ¥400,000)
KeywordsSynaptic plasticity / LTP / LTD / Calcium / Cortex
Research Abstract

Glutamate is the major excitatory neurotransmitter in the cerebral cortex. After blockade of NMDA and non-NMDA ionotropic glutamate receptors, tetanization to presynaptic fibers were induced long-term depression. Further experiments with agonists and antagonists suggested that some G protein-linked, inositol-1,4,5-trisphosphate (IP3)-coupled types of metabotropic glutamate receptors (mGluRs) are involved in induction of this long-term depression. Intracellular injection of the G-protein inhibitor GDPbetaS or the IP3 receptor inhibitor heparin prevented long-term depression but allowed long-term potentiation induction. Also Ca^<2+> chelation by EGTA prevented long-term depression. These experiments suggest that Ca^<2+> released from cytosolic stores resulted in long-term depression, whereas Ca^<2+> influxes lead to long-term potentiation. It thus seems that Ca^<2+> source may determine the whole fate of synaptic regulation.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] Kato,N.,and Yoshimura,H.: "Tetanization during GABA-A activation induces long-term depression in visual cortex slices." Neuropharmacology. 32. 511-513 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kato,N.: "Synaptic N-methyl-D-aspartate receptors in the neonatal rat visual cortex are less sensitive to MK-801 than in adult." Brain Res. 608. 166-168 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kato,N.,and Yoshimura,H.: "Facilitatory effects of substance P on susceptibility to long-term potentiation in the visual cortex of adult rats." Brain Res. 617. 353-356 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kato,N.,and Yoshimura,H.: "Reduced Mg^<2+> block of N-methyl-D-aspartate receptor-mediated synaptic potentials in developing visual cortex" Proc.Natl.Acad.Sci USA. 90. 7114-7118 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kato,N.: "Dependence of long-term depression on postsynatic metabotropic glutamate receptors in viusal cortex." Proc.Natl.Acad.Sci.USA. 90. 3650-3654 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kato,N.: "Mechanisms of β-adrenergic facilitation of LTP in rat visual cortex." Neuroreport. 4. 1087-1090 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kato N and Yoshimura H: "Tetanization during GABA-A activation induces long-term depression in visual cortex slices." Neuropharmacology. 32. 511-513 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kato N: "Synaptic N-methyl-D-aspartate receptors in the neonatal rat visual cortex are less sensitive to MK-801 than in adult." Brain Res. 608. 166-168 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kato N, Yoshimura H: "Facilitatory effects of substance P on Susceptibility to long-term potentiation in the visual cortex of adult rats." Brain Res. 617. 353-356 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kato N: "Mechanisms of b-adrenergic facilitation of LTP in rat visual cortex." Neuro Report. 4. 1087-1090 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kato N: "Dependence of long-term depression on postsynaptic metabotropic glutamate receptors in viusal cortex." Proc Nati Acad Sci USA. 90. 3650-3654 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kato N, Yoshimura H: "Reduced Mg^<2+>block of N-methyl-D-aspartate receptor-mediated synaptic potentials in developing visual cortex." Proc Natl Acad Sci USA.90. 7114-7118 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kato,N.,and Yoshimura,H.: "Tetanization during GABA-A activation induces long-term depression in visual cortex slices." Neuropharmacology. 32. 511-513 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kato,N.: "Synaptic N-methyl-D-aspartate receptors in the neonatal rat visual cortex are less sensitive to MK-801 than in adult." Brain Res. 608. 166-168 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kato,N.,and Yoshimura,H.: "Facilitatory effects of substance P on susceptibility to long-term potentiation in the visual cortex of adult rats." Brain Res. 617. 353-356 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kato,N.,and Yoshimura,H.: "Reduced Mg^<2+> block of N-methyl-D-aspartate receptor-mediated synaptic potentials in developing visual cortex" Proc.Natl.Acad.Sci USA. 90. 7114-7118 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kato,N.: "Dependence of long-term depression on postsynaptic metabotropic glutamate receptors in viusal cortex." Proc.Natl.Acad.Sci.USA. 90. 3650-3654 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kato,N.: "Mechanisms of β-adrenergic facilitation of LTP in rat visual cortex." Neuroreport. 4. 1087-1090 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Nobuo Kato: "Synaptic NMDA receptors in the neonatal rat visual cortex are less sensitive to MK-801 than in adult" Brain Res.

    • Related Report
      1992 Annual Research Report
  • [Publications] Nobuo Kato: "Dependence of long-term depression on postsynaptic metabotropic glutamate receptors in visual cortex" Proc.natl.Acad.Sci.USA.

    • Related Report
      1992 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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