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Ontogeny of Pge2 Fever

Research Project

Project/Area Number 04670093
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 環境生理学(含体力医学・栄養生理学)
Research InstitutionSHIGA UNIVERSITY

Principal Investigator

IMAI-MATSUMURA Kyoko  Shiga University, Faculty of Education, Associate Professor, 教育学部, 助教授 (40173877)

Co-Investigator(Kenkyū-buntansha) MATSUMURA Kiyoshi  Suzuka University of Medical Science and Technology, Department of Biomedical En, 医用工学部, 助教授 (10157349)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1992: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywordsontogeny / prostaglandin E_2 / fever / brain / rat / 幼若ラット / プロスタグランジン
Research Abstract

There are several steps to develop fever. Those are production of endogenous pyrogen, production of prostaglandin E2 (PGE2), neuronal response to PGE2, driving the effectors for heat production and heat conservation. All of these setps are indispensable for the febrile response. Although ontogeny of fever has been studied by several groups, there is little information which step is critical for the ontogenical development of fever. In the present study, we focused on the development of PGE2 receptor and PGE2 sensitivity in the preotic area.
Development of PGE2 receptor
1. PGE2 receptor in the rat brain is fairly low at the late gestational stage.
2. From postnatal day 5 to day 7, PGE2 receptor rapidly and transiently increased throughout the brain. Until 2 week, PGE2 receptor gradually decreased except for several regions, in which high density of PGE2 receptor is present in adult rat.
3. The density of PGE2 receptor in the anterior wall of the third ventricle, a presumed action site of PGE2 in producing fever, is higher than the surrounding region from postnatal day 1 and gradually increased. In 5 weeks, the density reaches to the adult level.
Development of PGE2 sensitivity
1. Injection of 100 ng PGE2 into the preoptic area of 7 day-old rats yielded gradual increase of rectal temperature. The amplitude of fever was less than the that of adult rat.
2. When 7 day-old rats were pretreated with dichrofenac, a potent inhibitor of prostaglandin synthesis, the same dose of PGE2 increased rectal temperature rapidly and intesely, the amplitude being 2.5 ゚C.
These results indicate that sensitivity to PGE2 and ability to produce PGE2 have been already present in 7 day-old rats.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] Matsumura,K.,Watanabe,Y.,Imai-Matsumura,K.,et al.: "Mapping of prostaglandin E2 binding sites in rat brain using quantitative autoradiography" Brain Research. 581. 292-298 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Matsumura, K., Watanabe, Y., Imai-Matsumura, K., et al.: "Mapping of prostaglandin E2 binding sites in rat brain using quantitative autoradiography." Brain Reseach. vol.581. 292-298 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Matsumura K.,Watanabe Y.,ImaiーMatsumura K., Connolly M.,Koyama Y.,Onoe H.,& Watanabe Y.: "Mapping of prostaglandin E_2 binding sites in rat brain using quantiative autoradiography." Brain Res.581. 292-298 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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