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Study of the biochemical processing of the biowarning information through the hypothalamu

Research Project

Project/Area Number 04670095
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 環境生理学(含体力医学・栄養生理学)
Research InstitutionKanazawa University (1993)
Kyushu University (1992)

Principal Investigator

SHIMIZU Nobuaki  Kanazawa Univ., Fac. of Techonol. Associate Prof., 工学部, 助教授 (50019634)

Co-Investigator(Kenkyū-buntansha) KATAFUCHI Toshihiko  Kyusu Univ., fac. of Med. Lecturer, 医学部, 講師 (80177401)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1992: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsImmobilization Stress / Feeding Behavior / Serotonin / Noradrenaline / Hypothalamus / Medial Prefrontal Cortex / Microdialysis / Splenic Sympathetic Nerve / ナチュラルキラー細胞活性
Research Abstract

This study was designed to study the dynamic changes in serotonin (5HT) and noradrenaline (NA) levels during the stressful stimuli, and have reached the following conclusions in rats. (1) Immobilization-stress caused anorexia in conjunction with an immediate increase in thehypothalamic 5HT release. Injection of 5HT receptor antagonist significantly reduced the immobilization-induced anorexia, suggesting that the hypothalamic serotonergic ystem is activated during stress and 5HT is an inhibitory transmitter in feeding behavior. (2) Immobilization elevated NA levels in the medial prefrontal cortex (PFC). Pre-injection of a benzodiazepine receptor agonist, diazepam, significantly attenuated the immobilization-induced NA release, while the injection of an anxiogenic compound, FG7142, facilitated it in non-stressed condition. Thus the stressfull stimuli activate the NA system in the medial PFC which may be modulated by an activation of the benzodiazepine receptors in the brain. (3) Immobilization-stress rapidly increased NA levels of spleen in conjunction with the suppression of natural killer (NK) cytotoxicity. Both theincreased levelsof NA ad he suppresion of NK cytotoxicity were significantly attenuated after surgical denervation of the splenic sympathetic nerve, indicating that immobilization-induced suppression of splenic N/K cytotoxicity was mediated predominantly through enhanced activity of the splenic sympathetic nerve..
These results suggest that both 5HT and NA may act asneurotransmitters and/or neuromodlators which regulate biowarning processes in the living body.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] Aoyagi,K.: "Concurrent measurement of serotonin metabolism and single neuron activity changes in the lateral hypothalamus of freely behaving rat." Behav.Brain Res.49. 205-212 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shimizu,N.: "In vivo measurement of hypothalamic serotonin release by intracerebral microdialysis:Significant enhancement by immobilization stress in rats." Brain Res.Bull.28(5). 727-734 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shimizu,N.: "Electrophysiological study of neurotropin-induced responses in guinea pig hypothalamic neurons." Brain Res.Bull.29(6). 767-772 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shimizu,N.: "An interleukin-1β-induced noradrenaline release in the spleen is mediated by brain corticotropin-releasing factor:An in vivo microdialysis study in conscious rats." Brain Behav.Immun.(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 清水宣明: "カルシトニンの作用:(4)中枢神経系に対する作用" The Born. 6(1). 69-74 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 清水宣明: "新しい空腹および満腹物質" Clinical Neuroscience. 11(4). 36-38 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Oomura,Y.: "Processing and inhibition of nociceptive information" Elsevier Science Publishers, 273 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Oomura,Y.: "Stress:Neuroendocrine and molecular approaches" Gordon & Breach Science Publishers, 510 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Aoyagi, K.: "Concurrent measurement of serotonin metabolism and single neuron activity changes in the lateral hypothalamus of freely behaving rat" Behav. Brain Res.49. 205-212 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shimizu, N.: "In vivo measurement of hypothalamic serotonin release by intracerebral microdialysis : Significant enhancement by immobilizatiion stress in rats" Brain Res. Bull.28 (5). 727-734 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shimizu, N.: "Electrophysiological study of neurotropin-induced responses in guinea pig hypothalamic neurons" Brain Res. Bull.767-772 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shimizu, N.: "An interleukin 1b-induced noradrenaline release in the spleen is mediated by brain corticotropin-releasing factor : An in vivo microdialysis study in conscious rats" Brain Behav. Immun.(in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Oomura, Y.: "Food intake under various noxious conditions. In : Processing and inhibition of nociceptive information. Eds : R.Inoki, Y.Shigenaga and M.Tohyama" Elsevier Sci. Publ.127-134 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Oomura, Y.: "Serotonergic involvement in feeding suppression after immobilization stress. In : Stress. Neuroendocrine and molecular approaches. Eds : R.Kvetnansky, R.McCarty & J.Axlrod" Gordon & Breach Sci. Publ.43-58 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Aoyagi,K.: "Concurrent measurement of serotonin metabolism and single neuron activity changes in the lateral hypothalamus of freely behaving rat." Behav.Brain Res.49. 205-212 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Shimizu,N.: "In vivo measurement of hypothalamic serotonin release by intracerebral microdialysis:Significant enhancement by immobilization stress in rats." Brain Res.Bull.28(5). 727-734 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Shimizu,N.: "Electrophysiological study of neurotropin-induced responses in guinea pig hypothalamic neurons." Brain Res.Bull.29(6). 767-772 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Shimizu,N.: "An interleukin-1β-induced noradrenaline release in the spleen is mediated by brain corticotropin-releasing factor.An in vivo microdialysis study in conscious rats." Brain Behav.Immun.(印刷中).

    • Related Report
      1993 Annual Research Report
  • [Publications] 清水宣明: "カルシトニンの作用:(4)中枢神経系に対する作用" The Born. 6(1). 69-74 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 清水宣明: "新しい空腹および満腹物質" Clinical Neuroscience. 11(4). 36-38 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Oomura,Y.: "Processing and inhibition of nociceptive information" Elsevier Science Publishers, 273 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Oomura,Y.: "Stress:Neuroendocrine and molecular approaches" Gordon & Breach Science Publishers, 510 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Shimizu,N.: "In vivo measurement of hypothalamic serotonin release by intracerebral microdialysis:significant enhancement by immobilization sress in rats" Brain Research Bulletin. 28. 727-734 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Aoyagi,K.: "Concurrent measurement of serotonin metabolism and single neuron activity changes in the lateral hypothalamus of freely behaving rat" Behavioural Brain Research. 49. 205-212 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Shimizu,N.: "Electrophysiological study of neurotropin-induced responses in guinea pig hypothalamic neurons" Brain Research Bulletin. 29. 767-772 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 清水 宣明: "ラット拘束ストレスによる摂食抑制と視床下部セロトニン動態" 第12回日本肥満学会記録誌. 108-110 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 清水 宣明: "カルシトニンの作用:(4)中枢神経系に対する作用" The Bone. 6. 69-74 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 清水 宣明: "新しい空腹一,満腹物質" Clinical Neuroscience.

    • Related Report
      1992 Annual Research Report
  • [Publications] Oomura,Y.: "Processing and Inhibition of Nociceptive Information" Elsevier Science Publishers, 273 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Oomura,Y.: "Stress:Neuroendocrine and Molecular Approaches" Gordon & Breach Science Publishers, 510 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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