| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1993: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1992: ¥900,000 (Direct Cost: ¥900,000)
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| Research Abstract |
In the present study, we investigated the tumor arsing from the T-cell area of the lymph node. Peripheral T-cell lymphoma (PTCL) was classified according to the updated Kiel (Suchi) classification. The clinicopathologic, phenotypic and genotypic findings of node-based, low-grade, PTCL (AILD type, T-zone type, and lymphoepithelioid type) were summarized (Cancer 1991 ; 67 : 2565). The proportion of the neoplastic cells (CD4+, Ki67+) in these tumors was demonstrated to have a relatively good correlation with the clonal TCRbeta rearrangement (Cancer 1993 ; 72 : 1762, Acta Pathol Jpn 1993 ; 43 : 396). In the process of the (Cancer 1993 ; 71 : 249). An accumulation of the additional 10 cases of this tumor suggested them to constitue a unique subgroup regarded as high-grade lymphoma, although some might be of natural killer (NK) cell lineage.
Interdigitating cell sarcoma was an extremely rare tumor arising from the paracortical area in the lymph node (Cancer 1988 ; 61 : 562). Recently, we described the histologic and immunophenotypic features of four cases of this tumor (Pathol Int 1994 ; in press).
We are going to examine the participation of oncogene and antioncogene in those tumors.
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