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Immunological studies on effect of concurrent HTLV-I infection on efficacy of treatment of strongyloidiasis

Research Project

Project/Area Number 04670234
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 寄生虫学(含医用動物学)
Research InstitutionUniversity of the Ryukyus

Principal Investigator

SATO Yoshiya  University of the Ryukyus, School of Medicine, Professor, 医学部, 教授 (60092699)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Jun  University of the Ryukyus, School of Medicine, Instructor, 医学部, 助手 (70225514)
TOMA Hiromu  University of the Ryukyus, School of Medicine, Instructor, 医学部, 助手 (80231447)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1992: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordsstrongyloidiasis / Strongyloides stercoralis / HTLV-I / adult T-cell leukemia (ATL) / therapeutic efficacy / immune response / HTLV-1 / 異型リンパ球
Research Abstract

A total of 206 patients with strongyloidiasis were treated with pyrvinium pamoate, thiabendazole and albendazole. The therapeutic efficacy by these anthelmintics was significantly lower in the patients with concurrent HTLV-I infection. The difference in efficacy was most significant in pyrvinium pamoate treatment which is less effective for treatment of strongyloidiasis. The relationship between immunological findings and the therapeutic efficacy in the patients was examined as follows. There was no difference in anti-Strongyloides antibody levels between the two groups with different therapeutic efficacy. Eosinophil counts in peripheral blood were relatively lower in the cured group and total serum IgE levels were higher in the same group, although the difference was not so significant. The higher level of perihperal eosinohpils was considered to be due to a relatively severe infection which might result in unsuccessful treatment, rather than the depressed eosinophil response in the cured group. When peripheral lymphocyte subsets were compared similarly, relative increase of helper and activated T-cell subsets were observed in the unsuccessfully treated group. The results, however, appeared to be due to HTLV-I infection among many patients in the group of unsuccessful treatment, because these subsets are known to increase in the HTLV-I carriers. The presence of atypical lymphocytes in peripheral blood was more frequent in the "unsuccessful treatment" group but the frequency was not different so significantly from the "cured" group. The results obtained could not determine the depressed immune responses in group resistant to anthelmintic treatment, as it was speculated in the start of this study.
In order to clarify the relationship between immune status and therapeutic efficacy, the immune response specific for Strongyloides should be further examined in treatment with more effective anthelmintics for strongyloidiasis.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Takara,M.,Toma,H.,Kobayashi,J.& Sato,Y.: "Effect of concurrent HTLV-I infection on the efficacy of pyrvinium pamoate treatment of strongyloidiasis." Jpn.J.Parasitol.14. 202-212 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sato,Y.,Shiroma,Y.,Kiyuna,S.,Toma,H.& Kobayashi,J.: "Reduced effect of chemotherapy of strongyloidiasis in patients with concurrent HTLV-I infection in Okinawa,Japan." Jpn.J.Trop.Med.Hyg.20. 183-192 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 佐藤良也: "沖縄における糞線虫症とATL.糞線虫とHTLV-Iの高率な混合感染とその背景" 医学のあゆみ. 162. 258 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 佐藤良也、城間祥行、大鶴正満: "糞線虫症とATL.糞線虫とHTLV-Iの高率な混合感染とその背景" 琉球医学会誌. 13. 3-12 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 當真弘、佐藤良也ほか: "アルベンダゾールによる糞線虫症治療成績" 寄生虫学雑誌. 42. 300-307 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sato,Y.,Shiroma,Y.,Kiyuna,S.,Toma,H.& Kobayashi,J.: "Reduced efficacy of chemotherapy might accumulate concurrent HTLV-I infection among strongyloidiasis patients in Okinawa,Japan." Trans.Roy.Soc.Trop.Med.Hyg.88. 59 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takara, M., Toma, H., Kobayashi, J.& Sato, Y.: "Effect of concurrent HTLV-I infection on the efficacy of pyrvinium pamoate treatment of strongyloidiasis." Japanese Journal of Parasitology. 41(3). 202-212 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sato, Y., Shiroma, Y., Kiyuna, S., Toma, H.& Kobayashi, J.: "Reduced effect of chemotherapy of strongyloidiasis in patients with concurrent HTLV-I infection in Okinawa, Japan." Japanese Journal of tropical Medicine and Hygiene. 20(3). 183-192 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sato, Y.: "Strongyloidiasis and ATL in Okinawa. A high frequency of HTLV-I infection among strongyloidiasis patients and its background." Igaku-no-Ayumi. 162(4). 258 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sato.Y., Shiroma, Y., & Otsuru, M.: "Strongyloidiasis and ATL.-A high concurrency of strongyloidiasis with HTLV-I infection and its background-" Ryukyu Medical Journal. 13(1). 3-12 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Toma, H., Sato, Y., Kobayashi, J., Shiroma, Y., Kiyuna, S., Takara, M., Uechi, K.& Ohtomo, H.: "Treatment of strongyloidiasis with albendazole in Okinawa, Japan." Japanese Journal of Parasitology. 42(4). 300-307 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sato, Y., Shiroma, Y., Kiyuna, S., Toma, H.& Kobayashi, J.: "Reduced efficacy of chemotherapy might accumulate concurrent HTLV-I infection among strongyloidiasis patients in Okinawa, Japan." Transactions of Royal Society of Tropical medicine and Hygiene. 88(1)(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 佐藤良也、城間祥行、大鶴正満: "糞線虫症とATL、糞線虫とHTLV-Iの高率な混合感染とその背景" 琉球医学会誌. 162. 3-12 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 當真 弘、佐藤良也 他: "アルベンダゾールによる糞線虫症治療成績" 寄生虫誌. 42. 300-307 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Sato,Y.et al.: "Reduced efficacy of chemotherapy might accumulate concurrent HTLV-I infection among strongyloidiasis patients in Okinawa,Japan." Trans.Roy.Soc.Trop.Med.Hyg.88. 59 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Takara,M.,Toma,H.,Kobayashi,J.and Sato,Y.: "Effect of concurrent HTLV-1 infection on the efficacy of pyrvinium pamoate treatment of strongyloidiasis" Japanese Journal of Parasitology. 41. 202-212 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Sato,Y.,Shiroma,Y.,Kiyuna,S.,Toma,H. and Kobayashi,J.: "Reduced effect of chemotherapy of strongyloidiasis in patients with concurrent HTLV-1 infection in Okinawa,Japan" Japanese Journal of Tropical Medicine and Hygiene. 20. 183-192 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 佐藤 良也、城間 祥行、大鶴 正満: "糞線虫症とATL.糞線虫とHTLV-1の高率な混合感染とその背景" 琉球医学会雑誌. 12. (1993)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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