Epidemiologic study on environmental and genetic factors for development of hypertension, A long-term follow-up study for two generations
| Project/Area Number |
04670324
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
公衆衛生学
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| Research Institution | University of Tsukuba |
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Principal Investigator |
ISO Hiroyasu U of Tsukuba, Insitute of Community, Medicine Associate Professor, 社会医学系, 助教授 (50223053)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMAMOTO Takashi U of Tsukuba, Institute of Community Medicine Professor, 社会医学系, 教授 (50143178)
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| Project Period (FY) |
1992 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1994: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1992: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | Hypertension / Environmental factor / Genetic factor / Follow-up study |
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| Research Abstract |
Factors related with development of hypertension were examined by 1) a 6 to 8 year follow-up of normotensive persons, and 2) comparison of blood pressure and related factors between parents and offsprings.
1. A follow-up of normotensive persons
Factors related with the development of hypertension among normotensive persons were examined by univariate and multivariate analyzes. Hypertension was defined as systolic blood pressure>=160mmHg, diastolic blood pressure >=95mmHg, and/or taking antihypertensive medication.In men, no relation was found between body mass index and blood pressure in the 1960s cohort, but significant relation appeared in the later cohorts. A substantial decline in manual work due to mechanization of farming may contributed to changes in the relation between body mass index and the development of hypertension.
Echocardiograpically-determined left ventricular mass (LVM) was significantly associated with an increase in blood pressure levels. The relation between LVM and
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blood pressure changes was stronger in urban men than in rural men. The weaker association between LVM and blood pressure increase in rural compared with urban men was probably the result of effects of higher physical activity, leading to a larger left ventricular internal dimension. An increased LVM predicts subsequent blood pressure increase in normotensive men in the presence of a normal or small internal dimension.
2. Blood pressure comparison between parents and offsrpings in a Akita rural population
Male offsprings showed a 10 mmHg lover mean systolic blood pressure than male parents, and female offsprings showed a 3 mmHg lower mean systolic blood pressure than female parents. Lower blood pressure levels in offsprings were attributable to lifestyle changes between 1960s and 1980s. A lack of significant association in blood pressure levels between male offsprings and parents may be due to larger effects of environmental factors then genetic factors in development of hypertension in this population. Less
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Report
(4 results)
Research Products
(18 results)
