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Purification of inhibitor of DNA synthsis in hepatoyte from blood of FHF patients

Research Project

Project/Area Number 04670412
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionUNIVERSITY OF TOKYO

Principal Investigator

YAMADA Haruki  TOKYO UNIVERSITY DEPARTMETN FACULTY OF MEDICINE ASSISTAN, 医学部(病), 助手 (70174729)

Co-Investigator(Kenkyū-buntansha) HASHIMOTO Naoaki  TOKYO UNIVERSITY DEPARTMETN FACALTY OF MEDICINE ASSISTAN, 医学部附属病院, 助手 (00167579)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1992: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsDNA synthosis / Livr Regeneration / 肝再生抑制因子 / 初代培養肝細胞 / 血漿交換 / 高速液体クロマトグラフィー / 逆浸透膜 / 中・低分子量 / ヘパリンカラム / EGF / インシュリン / ヒトHGF
Research Abstract

Inhitiory activity for DNA synthosis in adultrat primany hepatocyte culture, was measured in plasma from 20patient with actute liver failure. Inhibitory activity was increased in plasma of the patients with poor prognosis. Inhibitory activity was still inoreased after hepatic coma was disppeared by artifitial liver support.
Inhibitory activity in plasma from two individual FHF pationts was separated using heparing columm and HPLC (Amid80). Molecular size of the inhibitory activity was newgnized in the fraction between 100 and 3000 delton by membrane filtuation

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] H.Yamada: "Further purification and characterization of inhibitor of DNA synthesis in rat hepatocytes from blood of fulminant hepatic failure patients" Hepatology. 16. 179A (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] H.Yamada: "Humoral inhibitor of rat hepatocyte DNA synthesis from patients with fulminant liver failure" Hepatology. 19(5月号掲載予定). 8 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] H.Yamada: "Clinical significance of inhibitor(s) of DNA synthesis in rat hepatocytes in blood from fulminant hepatitis patients" Chinese J Gastroenterol. 10. 265 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 山田春木: "劇症肝炎患者血中のラット肝DNA合成抑制活性-血液浄化療法による変動" 肝臓. 34suppl.107 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] H.Yamada: "Partial purification and characterization of inhibitor of DNA synthesis in rat hepatocytes from blood of fulminant hepatic failue patients" Hepatology(第42回アメリカ肝臓病学会AASLD発表). 14. 105A- (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 山田 春木: "劇症肝炎患者血中の肝再生抑制物質ーHPLCを開いた部分精製" 肝臓. 33suppl.238- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 水戸 廸郎編: "肝再生をめぐる基礎と臨床" 東洋出版, (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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