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Regulation of heterologons intercellular communication in gastric epithebal cells

Research Project

Project/Area Number 04670415
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionFourth Department of Internal Medicine, University of Tokyo School of Medicine

Principal Investigator

AKIMOTO Kimihiko  Fourth Department of Internal Medicine, University of Tokyo Assistant Professor, 医学部(分), 助手 (70201283)

Co-Investigator(Kenkyū-buntansha) MINE Tetsuya  Fourth Department of Internal Medicine, University of Tokyo Assistant Professor, 医学部(分), 助手 (20157572)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1993: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1992: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordsconnexin / conncxon / gap junction / cultured rabbit gastric epethelial cells / cyclic AMP / Ca^<2+> / TPA / c kinase / Connexin / Connexon / 胃粘膜 / 細胞間コミュニケーション能 / サイクリックAMP / カルシウムイオン
Research Abstract

The gap jimction is a structure composed of intercellular channils that permit direct commurication by serving as passages for iono and small molecules between cells. Each gap junctional channels is composed of cornexon, forming a hemichannel in each of the joined membranes. In the present study, (1) Apperance of connexin in ulcer diseases (2) Apperance of connexin in experimental ulcer (3) regulation of gap jimction were inoestigated. Briefly, in chione ulcer, apperince of connexin 32,43, which was determined by using wester blotting of anti connexin 32,43 antibody, was abolished. In experimental designs, chromc ulcer wan madl, by using acetoacetate in rats. Appearences of conexin 32,43 were also abolished in ulcer. Finally, by using cultured rabbit gavtric macosa, regulation of intercellular comminucation was investigated. JBMX,forskslin and isoprotanenolincreased the production of cyclic AMP and increased the capacity of intercellular comminication. Carbacol and iononyan increased the cytoplamic free calcium concentration. From these data, in the gatric mcona, gapuinction plays an important role in glneretion of chronic gaspic ulceration and are regulated by some ligands.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Tetsuya Mine et al.: "Regulation of intercellular communictation of gap junction of cyclic AMP and Ca^<2+> incultured raffit gastric epithelial cells." Excerpta Medica. 9. 214-219 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tetsuya Mine et al.: "Regulation of intercellular communication at gap junction by Ca^<2+> in cultured raffit gastric epithclial cells." Excerpta Medica. 10. 191-194 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tetsuya Mine et al.: "Intercellular communication regulation at the gap junction by cyclic AMP and Ca^<2+> incultured raffit gastric epithelial cells." Proceeding of IMGJ. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tetsuya Mine et al.: "Regulation of intercellular communication of gap junction by cyclic AMP and Ca^<2+> in cultured rabbit gastric epithelial cells" Excerpta Medica. 9. 214-219 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tetsuya Mine et al.: "Regulation of intercellular communication at gap junction by Ca^<2+> in cultured rabbit gastric epithelial cells" Excerpta Medica. 10. 191-194 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tetsuya Mine et al: "Intercellular communication regulation at the gap junction by cyclic AMP and Ca^<2+> in cultured rabbit gastric epithelial cells" Procceding of IMGJ. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tetsuya Mine et al.: "Regulation of intercellular communication of gap junction by cyclic AMP and Ca^<2+> in cultured rabbit gastric epithelial cells" Excerpta Medica. 9. 214-219 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Tetsuya Mine et al.: "Regulation of intercellular communication at gap junction by Ca^<2+> in cultured rabbit gastric epithelial cells." Excerpta Medica. 10. 191-194 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Tetsuya Mine et al.: "Intercellular communication regulation at the gap junction by cyclic AMP and Ca^<2+> in cultured rabbit gastric epithelial cells." Proceeding of IMGJ. (in press).

    • Related Report
      1993 Annual Research Report
  • [Publications] Tetsuya Mine: "Regulation of intercellular communication at gap junction by Ca^<2+> in cultured rabbit gastric epithelial cells." Cytoprotection and Cytobiology. 10. 191-194 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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