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Significance of myocardial ischemia as a factor of the development of coronary collateral vessels

Research Project

Project/Area Number 04670523
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionKYOTO UNIVERSITY (1993)
Toyama Medical and Pharmaceutical University (1992)

Principal Investigator

FUJITA Masatoshi  KYOTO UNIVERSITY, College of Medical Technology, Professor, 医療技術短期大学部, 教授 (50190046)

Co-Investigator(Kenkyū-buntansha) MIWA Kunihisa  Toyama Med.& Pharm.Univ., Assistant, 医学部, 助手 (70166221)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1992: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsCoronary collaterals / Myocardial ischemia / Angina pectoris / Coronary angiography / Acute myocardial infarction
Research Abstract

1. Relationship between preinfarction angina and left ventricular function after acute myocardial infarction
Preinfarction angina is useful for the preservation of left ventricular function after acute myocardial function regardless of the early reperfusion of the infarct-related coronary artery The beneficial effect is, at least in part, due to the development of collateral circulation. On the other hand, ischemic preconditioning by preinfarction angina plays an important role in the preservation of left ventricular function in patients with the early reperfusion, whereas ischemic preconditioning is not useful for the preservation of left ventricular function in those with the persistently occluded infarct-related coronary artery
2. The development of coronary collateral circulation in patients with effort angina or acute myocardial infarction
In the presence of myocardial ischemic stimuli, collateral vessels are developed in all patients. The development of collateral channels is assess … More ed quantitatively as an increase in the diameter of recipient coronary arteries. The functional state of collateral circulation is determined by the anatomical presence of collateral vessels and pressure gradient across the collateral network.
3. Long-term efficacy of heparin exercise treatment for patients with stable effort angina
Repeated exercise with heparin pretreatment is useful for improving exercise capacity in patients with stable effort angina, and the beneficial effect of the treatment is maintained over a long follow-up period. The severity score of exercise thallium-201 myocardial scintigrams with the same work-load was significantly decreased long after heparin exercise treatnent.
4. Significance of stenosis of donating coronary arteries for collateral flow reserve
Coronary collateral circulation is further augmented in response to an increase in myocardial oxygen demand in patients with non-stenosed donating coronary arteries, whereas significant stenoses in donating arteries compromise an increase in collaterai blood flow. Less

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] Tadakazu Hirai: "Significance of preinfarction angina for preservation of left ventricular function in acute myocardial infarction." American Heart Journal. 124. 19-24 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Michiaki Ejiri: "Importance of non-stenosed donor coronary arteries for collateral flow reserve." International Journal of Cardiology. 39. 5-11 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Masatoshi Fujita: "A new method for assessment of collateral development after acute myocardial infarction." Journal of American College of Cardiology. 21. 68-72 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Masatoshi Fujita: "Long-term efficacy of heparin exercise treatment for patients with chronic effort angina." International Journal of Cardiology. 40. 51-56 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Naohiro Yoshida: "Relationship between collateral channel filling and flow grade in recipient coronary arteries in patients with stable effort angina." Journal of American College of Cardiology. 22. 426-430 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tadakazu Hirai: "Importance of ischemic preconditioning and collateral circulation for left ventricular functional recovery in patients with successful intracoronary thrombolysis for acute myocardial infarction." American Heart Journal. 126. 827-831 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 藤田正俊: "脳・心血管の病態とその発症機序" 共立出版株式会社, 170 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Masatoshi Fujita: "Recent Advances in Coronary Circulation" Springer-Verlag,Tokyo, 322 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hirai T, Fujita M, Yamanishi K, Ohno A, Miwa K, Sasayama S: "Significance of preinfarction anginal for preservation of left ventricular function in acute myocardial infarction." American Heart Journal. 124(1). 19-24 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ejiri M, Fujita M, Miwa K, Nozawa T, Asanoi H,Sasayama S: "Importance of non-stenosed donor coronary arteries for collateral flow reserve." International Journal of Cardiology. 39. 5-11 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fujita M, Ohno A, Miwa K, Moriuchi I Mifune J, Sasayama S: "A new method for assessment of collateral development after acute myocardial infarction." Journal of American College of Cardiology. 21(1). 68-72 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fujita M, Ohno A, Miwa K, Sasayama S, Futatsuya R, Seto H: "Long-term efficacy of heparin exercise treatment for patients with chronic effort angina : evaluation by exercise T1-201 myocardial scintigraphy." International Journal of Cardiology. 40. 51-56 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoshida N, Fujita M, Yamanishi K, Miwa K: "Relationship between collateral channel filling and flow grade in recipient coronary arteries in patients with stable effort angina." Journal of American College of Cardiology. 22(2). 426-430 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hirai T, Fujita M, Yoshida N, Yamanishi K, Inoko M, Miwa K: "Importance of ischemic preconditioning and collateral circulation for left ventricular functional recovery in patients with successful intracoronary thrombolysis for acute myocardial infarction." American Heart Journal. 126(4). 827-831 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Masatoshi Fujita: "A new method for assessment of collateral development after acute myocardial infarction." Journal of American College of Cardiology. 21. 68-72 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kazuto Yamanishi: "Effects of intracoronary injection of acetylcholine on coronary collateral circulation." Catheterization and Cardiovascular Diagnosis. 28. 114-118 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Masatoshi Fujita: "Long-term efficacy of heparin exercise treatment for patients with chronic effort angina." International Journal of Cardiology. 40. 51-56 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Naohiro Yoshida: "Relationship between collateral channel filling and flow grade in recipient coronary arteries in patients with stable effort angina." Journal of American College of Cardiology. 22. 426-430 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Tadakazu Hirai: "Importance of ischemic preconditioning and collateral circulation for left ventricular functional recovery in patients with successful intracoronary thrombolysis for acute myocardial infarction." American Heart Journal. 126. 827-831 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Akira Ohno: "Comparative efficacy of thrombolytic therapy for acute myocardial infarction in patients with and without chronic preinfarction angina." Cardiology. 83. 93-99 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Masatoshi Fujita: "Recent Advances in Coronary Circulation" Springer-Verlag,Tokyo, 322 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 藤田正俊: "研修医ノート,ベッドサイドの手技と診察" 診断と治療社, 479 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Shigetake Sasayma: "Recent insights into coronary collateral circulation." Circulation. 85. 1197-1204 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Etsuro Araie: "Relationship between the preexistent coronary collateral circulation and successful intracoronary thrombolvsis for acute myocardial infarction." American Heart Journal. 123. 1452-1455 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tadakazu Hirai: "Significance of preinfarction angina for preservation of left ventricular function in acute myocardial infarction" American Heart Journal. 124. 19-24 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Masatoshi Fujita: "A new method for assessment of collateral development after acute myocardial infarction." Journal of American College of Cardiology. 21. 68-72 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Michiaki Ejiri: "Importance of non-stenosed donor coronary arteries for collateral flow reserve(in press)." International Journal of Cardiology. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Masatoshi Fujita: "Long-term efficacy of heparin exercise treatment for patients with chronic effort angina:evaluation by exercise T1-201 myocardial scintigraphy (in press)." International Journal of Cardiology. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 藤田 正俊: "脳・心血管の病態とその発症機序" 共立出版株式会社, 170 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Masatoshi Fujita: "Recent Advances in Coronary Circulation" Springer-Verlag, Tokyo, (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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