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Pathoplysiolgical role of brain natiuretic polypeptide(BNP) in hypertension and cordiovascular diseases

Research Project

Project/Area Number 04670544
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionMiyazaki Medical College

Principal Investigator

ETO Tanenao  Miyazaki Medical College, Faculty of Medicine, Professor, 医学部, 教授 (10038854)

Co-Investigator(Kenkyū-buntansha) KITAMURA Kazuo  Miyazaki Medical College, Faculty of Medicine, Research associate, 医学部, 助手 (50204912)
木田 修  宮崎医科大学, 医学部, 助手 (00177875)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1993: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1992: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsAtrial natriuretic polypeptide / Brain natriuretic polypeptide / c-type natriuretic polypeptide / adrenomedullin / hypertension / nephrotic syndrome / congestive heart failure / 心房ナトリウム利尿ホルモン / 脳性ナトリム利尿ホルモン / 脳性ナトリウム利尿ペプチド / 心房性ナトリウム利尿ペプチド / 自然発症高血圧ラット / DOCA-食塩高血圧 / ストレプトゾトシン糖尿病
Research Abstract

In order to investigate the pathophysiological role of brain netriuretic polypeptide (BNP), biosynthesis and secretion of BNP and atrial natriuretic polypeptide (ANP) was investigated in spontaneously hypertensive rats and adrimycine-induced nephrotic rats. Raised blood pressure stimulates both ANP and BNP, however, production of BNP in the ventricles is already increased in the prehypertensive stage, and in older hypertensive rats, it is more responsive to progression of hypertension than ANP.In the adriamycine-model of the nephrotic syndrome, there is a rise in plasma level of BNP and a remarkable resisance to some hemodynamic and renal effects of exogenously administere BNP.These results indicate that BNP as well as ANP participates in circulation control in hypertension and nephrotic syndrome model rats.
Mammalian circulation is regulated by subtle mechanisms involving several neural and hormonal factors. Several vasoactive peptides including angiotensin, ANP and endothelin are important regulators in the cardiovascular system. For clarifying the intricacies of blood pressure control, it is important to discover still unidentified vasoactive peptide.
In this contex, we have been searching for peptides which may contribute to circulation control, using an assay system whivh monitors the elevating activity of platelet cAMP.We recently discovered a novel hypotensive peptide "adrenomedullin(AM)"from pheochromocytoma tissue extract. AM elicited a potent and long lastin hypotensive activity in anesthetized rats. AM circulate in blood in a considerable concentration and signigicantly increased in patients with hypotension, renal failure and congestive heart failure. These results indicate that AM is a possible new hormon participating in circulation control. The discovery of AM indicates a existence of a novel system for circulation control.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] Yusyiro ISHIZAKA: "ISOLATION AND IDENTIFICATION OF C-TYPE NATRIURETIC PEPTIDE IN HUMAN MONOCYTIC CELL LINE,THP-1" BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 189. 697-704 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Naoto Yokota: "Alterations in circulating and cardiac tissue concentrations of natriuretic peptide in spontaneously hypertrnsive rats" cardiovascular Research. 27. 1312-1315 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Naoto Yokota: "Increased Plasma Levels and Effects of Brain Natriuretic Peptide in Experimental Nephrosis" Nephron. 65. 454-459 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kazuo Kitamura: "ADRENOMEDULLIN:A NOVEL HYPOTENSIVE PEPTIDE ISOLATED FROM HUMAN PHEOCHROMOCYTOMA" BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 192. 553-560 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kazuo Kitamura: "CLONING AND CHARACTERIZATION OF cDNA ENCODING A PRECURSOR FOR HUMAN ADRENOMEDULLIN^1" BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 194. 720-725 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Junichiro Sakata: "MOLECULAR CLONING AND BIOLOGICAL ACTIVITIES OF RAT ADRENOMEDULLIN,A HYPOTENSIVE PEPTIDE" BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 195. 921-927 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yuichiro Ishiyama: "Hemodynamic effects of a novel hypotensive peptide,human adrenomedullin,in rats" European Journal of Pharmacology, (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yusyiro ISHIZAKA: "ISOLATION AND IDENTIFICATION OF C-TYPE NATRIURETIC PEPTIDE IN HUMAN MONOCYTIC CELL LINE,THP-1" BIOCHMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 189. 697-704 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Naoto Yokota: "Alterations in circulating and cardiac tissue concentrations of natriuretic peptide in spontaneously hypertrnsive rats" cardiovascular Reserch. 27. 1312-1315 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Naoto Yokota: "Increased Plasma Levels and Effects of Brain Natriuretic Peptide in Experimental Nephrosis" Nephron. 65. 454-459 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kazuo Kitamura: "ADRENOMEDULLIN:A NOVEL HYPOTENSIVE PEPTIDE ISOLATED FROM HUMAN PHEOCHROMOCYTOMA" BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 192. 553-560 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kazuo Kitamura: "CLONING AND CHARACTERIZATION OF cDNA ENCODING A PRECURSOR FOR HUMAN ADRENOMEDULLIN^1" BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 194. 720-725 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Junichiro Sakata: "MOLECULAR CLONING AND BIOLOGICAL ACTIVITIES OF RAT ADRENOMEDULLIN A HYPOTENSIVE PEPTIDE" BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 195. 921-927 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yuichiro Ishiyama: "Hemodynamic effects of a novel hypotensive peptide,human adrenomedullin,in rats" ECULAR CLONING AND BIOLOGICAL ACTIVITIES OF RAT ADRENOMEDULLIN,A HYPOTENSIVE PEPTIDE, (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yushiro Ishizaka: "Isolation and identification of C-type natriuretic peptide in human monocyte cell line,THP-1" Biochemical and Biophysical Research Communication. 189. 697-704 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Naoto Yokota: "Increased plasma levels and effects of brain natriuretic peptide in experimental nephrosis" Nephron.

    • Related Report
      1992 Annual Research Report
  • [Publications] Naoto Yokota: "Al terations in Circulating levels and cardiac tissue concentrations of brain natriuretic peptide in spontaneously hypertensive rats." Cardiovascular Research.

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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