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STUDIES ON THE DEVELOPMENT OF CIRCADIAN, ULTARADINAN AND INFRADIAN RHYTHMS IN BIOLOGICAL ACTIVITY.

Research Project

Project/Area Number 04670572
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionASAHIKAWA MEDICAL COLLEGE

Principal Investigator

OKUNO Akimasa  ASAHIKAWA MEDICAL COLLEGE DEPT PED, PROFESSOR, 医学部, 教授 (10000960)

Co-Investigator(Kenkyū-buntansha) KAKUYA Fujio  ASAHIKAWA MEDICAL COLLEGE DEPT PED, INSTRUCTOR, 医学部, 助手 (70240645)
ITO Yoshiya  ASAHIKAWA MEDICAL COLLEGE DEPT PED, INSTRUCTOR, 医学部, 助手 (70241437)
OKI Junichi  ASAHIKAWA MEDICAL COLLEGE DEPT PED, INSTRUCTOR, 医学部, 助手 (60152401)
AZUMA Hiroshi  ASAHIKAWA MEDICAL COLLEGE DEPT PED, INSTRUCTOR, 医学部, 助手 (00167909)
矢野 公一  旭川医科大学, 医学部, 助手 (60182383)
岡 敏明  旭川医科大学, 医学部, 講師 (30111206)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1992: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsCIRCADIAN RHYTHM / ULTRADIAN RHYTHM / INFRADIAN RHYTHM / LETEINIZING HORMONE / FOLLICLE STIMULATING HORMONE / TESTOSTERONE / PUBERTY / 性成熟 / 長日リズム / 成長速度 / ゴナドトロピン / インターロイキン
Research Abstract

Biological rhythms were studied on the development of pituitary-gonadal function in children and adolescents, the weight gain in low-birth weight infants and the cardiac functions in the children with insulin dependent diabetes mellitus.
(1) Characteristics of physical growth and hormonal changes during childhood and adolescence studied on the basis of height velocity, testicular size, and 24-hr secretory pattern of LH, FSH and testosterone. Definite pulsatile secretion and day-night rhythm are observed in the hormonal concentrations as early as five years of age. The mean 24-hr concentrations of LH and FSH started to increase one year before the testicular size came to 3 ml. Immediately after the rise in LH and FSH, the minimal prespurt height velocity was attained and the the mean 24-hr testosterone concentration started to increase.
(2) Body-weight measured every other day was analyzed for rhythms of weight velocity in low birth eight infants. There was an infradian rhythm with a cycle of 9.28 (〕SY.+-.〔) l.05 days. This infradian rhythm in the weight velocity was not affected by water and energy intake and medical manipulation.
(3) Cardiac contraction rhythms were analyzed by doppler echocardiography in the patients with insulin-dependent diabetes mellitus. Measurement of the mitral and tricuspidal flow showed prolongation of the early diastolic phase of the both ventricle.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] 角谷不二雄: "体重増加の長日リズム:低出生体重児における検討" 日本小児科学会雑誌. 96. 2048-2053 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoshiya Ito: "Sporadic Testotoxicosis in Japanese Children." Clin Pediatr Endocrinol. 1. 95-100 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 三田村亮: "思春期の発来と血清テストステロン・黄体化ホルモンの日内リズムとの関係" 日本小児科学会雑誌. 97. 2101-2110 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 土田晃: "インスリン依存性糖尿病患児における心機能の検討" 日本小児科学会雑誌. 97. 2412-2420 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Akimasa Okuno: "Physical Growth and Hormonal Chnages in Late Childhood" Clin Pediatr Endocrinol. Suppl 3. 1-6 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kakuya F, Tsuda N, Hayashi T, shirai M, Ishioka t, Okuno A: "An infradian rhythm of weight velocity on low birth weight infants." J Japn Pediatr Soc. 96( Janpanese ). 2048-53 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kakuya F, Tsuda N, Hayashi T, shirai M, Ishioka t, Okuno A: "An infradian rhythm of weight velocity on low birth weight infants." J Japn Pediatr Soc. 96( Janpanese ). 2048-53 (1992)Ito Y, Yano K, Mitamura R, Oka R, Okuno A, Kataoka N, Hiraba K, Moriya N : Sporadic testotoxicosis in Janpanese children : report of 4 cases. clin Pediatr Endocrinol 1 : 95-100, 1992:

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Mitamura R, Ohmi H, Ito Y, Suzuki N,Yano K, Okuno A: "Diurnal rhythms of testosterone and luteinizing hormone in boys before and during the onset of puberty." J Japn Pediatr Soc. 97( Japanese ). 2101-10 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tsuchida A, Mitamura R, Sakaino T, Saito T, Ito Y, Suzuki N, Yano K, Oka R, Okuno A: "doppler echocardiographic evaluation of left and rightventricular functions in young subjects with insulin-dependent diabetes mellitus." J Japan Pediatr Soc. 97( Janpanese ). 2412-20 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Okuno A: "Physical growth and hormonal changes in late cildhoodand early adolescence." clin Pediatr Endocrinol. Suppl 3. 1-6 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 角谷 不二雄: "体重増加の長日リズム:低出生体重児における検討" 日本小児科学会雑誌. 96. 2048-2053 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yoshiya Ito: "Sporadic testotoxicosis in Japanese children" Clin Pediatr Endocrinol. 1. 95-100 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 三田村 亮: "思春期の発来と血清テストステロン、黄体化ホルモンの日内リズムとの関係" 日本小児科学会雑誌. 97. 2101-2110 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 土田 晃: "インスリン依存性糖尿病患児における心機能の検討" 日本小児科学会雑誌. 97. 2412-2420 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Akimasa Okuno: "Physical growth and hormonal chnages in late childhood-----" Clin Pediatr Endocrinol. Suppl 3. 1-6 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 東 寛: "血清Interleukin6活性の基礎値の加齢に伴う変動について" 日本小児科学会雑誌. 96. 1177-1181 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Azuma,H: "Cytochrome b positive X-linked chronic granulomatous disease : a normal Cell surface expression of cytochrome b" Eur J Pediatr. 151. 279-282 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Zhang,D,H: "Growth hormone secretory status in patient with Turner syndrome" Acta Paediatr Jpn. 34. 282-289 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 角谷 不二雄: "体重増加速度の長日リズム:低出生体重児における検討" 日本小児科学会雑誌. 96. 2048-2053 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 沖 潤一: "点頭てんかん患者のACTH療法中の経過およびCRH負荷試験試験" ACTH Related Peptide. 3. 117-122 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ito,Y: "Sporadic Testotoxicosis in Japaneses Children:Report of 4 cases" Clin Pediatr Endocrinol. 1. 95-100 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 沖 潤一: "消化管ホルモン(XI)9.ACTE漸減中に発症した重篤な食時下痢対するTRH療法" 消化管ホルモン研究会・医学図書出版, 447 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 奥野 晃正: "成長異常疾患ガイドブック" Biomedis, 340 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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