| Project/Area Number |
04670607
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Nagasaki University |
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Principal Investigator |
TSUJI Yoshiro Nagasaki University, Professor, 医学部, 教授 (30039812)
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| Project Period (FY) |
1992 – 1994
|
| Project Status |
Completed (Fiscal Year 1994)
|
| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1994: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1993: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1992: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | HTLV-1 / breast milk infection / carrier mother / mother-to-child transmission / breast-fed |
|---|
| Research Abstract |
Prevention of mother-to-child transmission of HTLV-1.
Human T-lymphotropic virus type I (HTLV-1) is closely linked with serious diseases, such as adult T-cell leukemia (ATL), tropical spastic pararesis/HTLV-1 associated myelopathy (TSP/HAM) and HTLV-1 assosiated retinophathy (HAR). Unfortunately, it is not currently possible to care the diseases. The only way aviable to provent thease diseases is breaking the cycle of HTLV-1 endemy.
HTLV-1 is heavily endemic in Nagasaki. The prevelance of carriers in Nagasaki is approximately 4% in pregnant women.
The main route of HTLV-1 transmission has been established as maternal, specifically via breast milk. The incidence of maternal transmission is 20-30%. Maternal transmission were remearkably decreased to the level of 3% in formula-fed.
Approximately 90% of maternal infection was blocked by refraining of breast feeding by carrier mothers.
The incidence of infection in group of breast-fed over 6 month was 16.2%, under 6 month was 10.4% and in the group of formula-fed was 2.7%.
Comparing the long term breast-fed group and the short term-breast-fed group, I can't find any differene between them.
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