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A study on the roles of anti-ubiquitin antibody in collagen disease

Research Project

Project/Area Number 04670648
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionKitasato University School of Medicine Grant-in-Aid for Scientific Research (C)

Principal Investigator

ETO Hikaru  Kitasato Univ School of Med, Dept. of Dermatology, Associate Professor, 医学部, 助教授 (20137920)

Co-Investigator(Kenkyū-buntansha) 関根 敦子  北里大学, 医学部, 助手 (50226651)
浅井 寿子  北里大学, 医学部, 助手 (20231863)
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1993: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1992: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsUbiquitin / Anti-ubiquitin antibody / SLE / Collagen disease / 皮膚病変 / 抗体ユ-ビキチン抗体 / ユービキチン / 抗ユービキチン抗体 / リベド / CNSループス
Research Abstract

Ubiquitin is a kind of heat-shock protein which evolutionally preserved. A series of investigations were designed to reveal pathogenetic roles on collagen-vascular diseases including systemic and cutaneous lupus erythematosus. From our studies, several interesting results were found ; (1) Among SLE patients, 70% of sera showd positive the anti-ubiquitin antibody of IgG and IgM classes. (2) Among skin manifestations, there are statistically significant correlation between livedo reticularis and elevated titer of anti-ubiquitin antibody. (3) Among systemic manifestations, CNS lupus showed significant correlation to elevated anti-ubiquitin antibody. (4) Immunohistochimical studies showd that the strong expression of ubiquitin on epidermis and appendage epithelial cells in SLE skin lesions. (5) These immunohistochemical expression of ubiquitin were also found on pemphigus vulgaris, bullous pemphigoid, poriasis and other inflammatory skin diseases. (6) Non-inflammatory skin lesions including nevus cell nevus and systemic sclerosis showed only very weak expression on epidermis.
These results suggest that the expression of ubiquitin in skin may occur in various inflammatory skin lesions and serum anti-ubiquitin antibody in SLE may be the secondary phenomenon.

Report

(4 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] 刀祢真理,衛藤光,西山茂夫,佐藤光男,佐藤征二: "Systemic Lupus Erythematosus (SLE)患者における抗Ubiquitin抗体の存在" 日本皮膚科学会雑誌. 102. 963-969 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 刀祢 真理、衛藤 光、西山 茂夫、佐藤 光男 佐藤 征二: "Systemic Lupus Erythematosus(SLE)患者における抗Ubiquitin抗体の存在" 日本皮膚科学会雑誌. 102. 963-969 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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