• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

APPLOCATION OF LUNG RECEPTOR IMAGING TO THERAPEUTIC DRUG MONITERING (FOUNDAMENTAL EVALUATION WITH ANIMAL POSITRON CT)

Research Project

Project/Area Number 04670659
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionGUNMA UNIVERSITY SCHOOL OF MEDICINE

Principal Investigator

INOUE Tomio  GUNMA UNIVERSITY SCHOOL OF MEDICINE, DEPARTMENT OF NUCLEAR MEDICINE, ASSOCIATE PROFESSOR, 医学部・核医学教室, 助教授 (80134295)

Co-Investigator(Kenkyū-buntansha) TOMIYOSHI Katsumi  GUNMA UNIVERSITY SCHOOL OF MEDICINE, DEPARTMENT OF NUCLEAR MEDICINE, LECTURER, 医学部・核医学教室, 助手 (60188802)
ENDO Keigo  GUNMA UNIVERSITY SCHOOL OF MEDICINE, DEPARTMENT OF NUCLEAR MEDICINE, PROFESSOR, 医学部・核医学教室, 教授 (10115800)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1992: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsReceptor imaging / Therapeutic drug monitering / Positron CT
Research Abstract

We have tried to develop the method of lung receptor imaging which may sesolve the mechanism of asthma and give useful information regarding to therapeautic drug monitering.
1. Animal experiment to measure the lung uptake of radioiodine MIBG.
The lung uptake of I-131 MIBG has been measured using dual tracer technique with I-131MIBG and Tc-99m HSA, which needed to take sequential arterial blood samples. About 30% of MIBG lung uptake was shown in this experiment using guinea pigs and its uptake presented the dose dependency. We also develop the computer software to measure the lung uptake of radiolabeled receptor ligand without blood sampling data.
2. Animal experiment with aerolized radiotracer inhalation technique.
Pharmacokinetics of aerolized MIBG in the lung has been investigated with scintigraphic technique. It suggested that the location of receptor which mainly bind a drug depended on the rout of drug administration.
3. Animal experiment with high resolution animal PET.
We produced the C-11 pyrilamine as a ligand of H1 receptor and obtained 95% of chemical purify. We also succeeded to obtain the lung image of guinea pigs with C-11 pyrilamine but the problem of quality control of this radiopharrmaceutical has been remained.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] N.Watanabe, T.Hirano, T.Inoue, K.Endo: "Transient unilateral reverse ventilation/perfusion mismatch in a patient with lung cancer." Clin. Nucl. Med. 17. 705-707 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Inoue, K.Endo, T.Hirano et al: "Imaging of bone metabolism with fluorine-18-fluoride ion using a high resolution animal PET" Bioimages. 1. 27-30 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Inoue, M.Tateno, N.Watanabe et al: Effect of inhaled furosemide on Tc-99m DTPA aerosol lung clearance. J.Nucl. Med, 42 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary

URL: 

Published: 1992-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi