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The Development and Application of Diffusion-weighted Echo Planar Images

Research Project

Project/Area Number 04670670
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionHIROSHIMA UNIVERSITY

Principal Investigator

AZUMA Kazuyoshi  Hiroshima Univ. Med. Hosp. Assist. Prof., 医学部・附属病院, 講師 (50127601)

Co-Investigator(Kenkyū-buntansha) AWAI Kazuo  Hiroshima Univ. Med. Hosp. Resident, 医学部・附属病院, 医員
TSUJI Shuichi  Hiroshima Univ. Med. Hosp. Research Associate, 医学部・附属病院, 助手 (30217301)
KAJIMA Toshio  Hiroshima Univ. Sch. Med. Research Associate, 医学部, 助手 (00224410)
ITO Ktsuhide  Hiroshima Univ. Sch. Med. Prof., 医学部, 教授 (20034035)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1993: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1992: ¥300,000 (Direct Cost: ¥300,000)
KeywordsCerebral ischemia / Diffusion-weighted image / Echo-planar image / Anisotropic diffusion / 拡散強調像
Research Abstract

Diffusion-weighted echo-planar images (DW-EPI) with motion-probing-gradient (MPG) method were acquired using MR imager (2.0 tesla). Apparent diffusion coefficient (ADC) were calculated from these images in ischemic lesions and in normal unoccluded regions. Focal cerebral ischemia was produced by occlusion of the intracranial main cerebral artery with a silicone cylinder in Wistar rats. Results were as follows.
1) Ischemic lesious could be detected on the DW-EPI at 1 hour after occlusion.
2) The ADC of water in the brain tissue was smaller than that of free water as a result of restricted diffusion.
3) Anisotropic diffusion that probably can be attributed to the myelin sheath was observed in the normal deep white matter.
4) In the ischemic lesions, the ADC decreased rapidly within 1-3 hours after occlusion and then decreased gradually after 24-48 hours. In the ischemic deep white matter, diffusion anisotropy disappeared at 24-48 hours after occlusion.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Toshio Kajima: "Diffusion Weighted Echo-planar Imaging of Cerebral Ischemia" SMRM,Book of Abstracts. 6. 1810 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Toshio Kajima: "Diffusion Anisotropy of Cerebral Ischemia" Acta Neurochir. 119(in print). (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 東 和義: "INNERVISION" 医療科学社(発表予定), (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Toshio Kajima, Kazuyoshi Azuma, Katsuhide Ito, Reiko Kagawa, Kanji Yamane, Yoshikazu Okada, Takeshi Shima: "Diffusion Anisotropy of Cerebral Ischemia." Acta Neurochir. 119 (in print). (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Kajima, K.Awai, K.Ito, R.Kagawa, Y.Okada, T.Shima, Y.Okamoto, E.Yoshitome: "Diffusion-weighted Echo-planar imaging of Cerebral Ischemia" SMRM (Book of Abstracts). 6. 1810 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Toshio Kajima: "Diffusion Anisotropy of Cerebral Ischemia" Acta Neurochir. 119(in print). (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 東 和義: "INNERVISION" 医療科学社(発表予定), (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Toshio Kajima: "Diffusion amisotropy of cerebral is chemia" Acta Neurochirurgica. (1993)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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