| Project/Area Number |
04670670
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
AZUMA Kazuyoshi Hiroshima Univ. Med. Hosp. Assist. Prof., 医学部・附属病院, 講師 (50127601)
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| Co-Investigator(Kenkyū-buntansha) |
AWAI Kazuo Hiroshima Univ. Med. Hosp. Resident, 医学部・附属病院, 医員
TSUJI Shuichi Hiroshima Univ. Med. Hosp. Research Associate, 医学部・附属病院, 助手 (30217301)
KAJIMA Toshio Hiroshima Univ. Sch. Med. Research Associate, 医学部, 助手 (00224410)
ITO Ktsuhide Hiroshima Univ. Sch. Med. Prof., 医学部, 教授 (20034035)
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1993: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1992: ¥300,000 (Direct Cost: ¥300,000)
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| Keywords | Cerebral ischemia / Diffusion-weighted image / Echo-planar image / Anisotropic diffusion / 拡散強調像 |
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| Research Abstract |
Diffusion-weighted echo-planar images (DW-EPI) with motion-probing-gradient (MPG) method were acquired using MR imager (2.0 tesla). Apparent diffusion coefficient (ADC) were calculated from these images in ischemic lesions and in normal unoccluded regions. Focal cerebral ischemia was produced by occlusion of the intracranial main cerebral artery with a silicone cylinder in Wistar rats. Results were as follows.
1) Ischemic lesious could be detected on the DW-EPI at 1 hour after occlusion.
2) The ADC of water in the brain tissue was smaller than that of free water as a result of restricted diffusion.
3) Anisotropic diffusion that probably can be attributed to the myelin sheath was observed in the normal deep white matter.
4) In the ischemic lesions, the ADC decreased rapidly within 1-3 hours after occlusion and then decreased gradually after 24-48 hours. In the ischemic deep white matter, diffusion anisotropy disappeared at 24-48 hours after occlusion.
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